Gene

tpm1

ID

ZDB-GENE-040426-854

Name

tropomyosin 1 (alpha)

Symbol

tpm1 Nomenclature History

Previous Names

TPM1-1 (1)
zgc:171719
zgc:55951 (1)
zgc:77009

Type

protein_coding_gene

Location

Chr: 25 Mapping Details/Browsers

Description

Predicted to enable actin filament binding activity. Predicted to be involved in actin filament organization and cardiac muscle contraction. Predicted to be active in actin filament. Is expressed in adaxial cell; heart; and musculature system. Human ortholog(s) of this gene implicated in congenital myopathy 4A; dilated cardiomyopathy 1Y; familial hypertrophic cardiomyopathy; hypertrophic cardiomyopathy 3; and nemaline myopathy 1. Orthologous to several human genes including TPM1 (tropomyosin 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

13 figures from 7 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:55951 (21 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With tpm1 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
dilated cardiomyopathy 1Y	Alliance	Cardiomyopathy, dilated, 1Y	611878
dilated cardiomyopathy 1Y	Alliance	Left ventricular noncompaction 9	611878
hypertrophic cardiomyopathy 3	Alliance	Cardiomyopathy, hypertrophic, 3	115196

Associated With tpm1 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Family	IPR000533	Tropomyosin
Homologous_superfamily	IPR014751	DNA repair protein XRCC4-like, C-terminal

Domain Details Per Protein

Protein	Length	DNA repair protein XRCC4-like, C-terminal	Tropomyosin
UniProtKB:A7E2K1 InterPro	247
UniProtKB:A0A8M9PYA8 InterPro	284
UniProtKB:A0A8M2BLL0 InterPro	284
UniProtKB:A0A8M9P6D8 InterPro	244
UniProtKB:E7FBZ3 InterPro	284
UniProtKB:Q6NYQ0 InterPro	284
UniProtKB:A0A8M9PUV7 InterPro	247
UniProtKB:A0A8M2BLW9 InterPro	244
UniProtKB:A0A2R8RQ88 InterPro	247
UniProtKB:A0A1L6UW63 InterPro	284
UniProtKB:A0A8M3APV7 InterPro	284
UniProtKB:A0A8M2BLM4 InterPro	284
UniProtKB:A0A8M6Z4C1 InterPro	281
UniProtKB:Q7ZVK9 InterPro	284
UniProtKB:A0A8M2BLW8 InterPro	284
UniProtKB:A0A8M3AZU4 InterPro	247

Transcripts

Genome Browsers

NCBI

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	tpm1-201 (1) Ensembl	Ensembl	856 nt	Select Tool ZFIN BLAST
mRNA	tpm1-202 (1) Ensembl	Ensembl	1,742 nt	Select Tool ZFIN BLAST
mRNA	tpm1-203 (1) Ensembl	Ensembl	1,256 nt	Select Tool ZFIN BLAST
mRNA	tpm1-204 (1) Ensembl	Ensembl	1,595 nt	Select Tool ZFIN BLAST
mRNA	tpm1-205 (1) Ensembl	Ensembl	4,826 nt	Select Tool ZFIN BLAST
mRNA	tpm1-206 (1) Ensembl	Ensembl	3,872 nt	Select Tool ZFIN BLAST
mRNA	tpm1-207 (1) Ensembl	Ensembl	4,798 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

Name	Type	Antigen Genes	Isotype	Host Organism	Assay	Source	Citations
Ab1-tpm1	polyclonal	tpm1	IgG	Rabbit	WB	ABclonal	1

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations