igfbp7

ID

ZDB-GENE-040426-2423

Name

insulin-like growth factor binding protein 7

Symbol

igfbp7 Nomenclature History

Previous Names

agm (1)
angiomodulin (1)
zgc:85888

Type

protein_coding_gene

Location

Chr: 14 Mapping Details/Browsers

Genome Assembly

GRCz12tu

Annotation Status

Current

Description

Enables identical protein binding activity. Acts upstream of or within branching involved in blood vessel morphogenesis and sprouting angiogenesis. Predicted to be non-collagenous component of basement membrane. Predicted to be active in extracellular region. Is expressed in several structures, including cardiovascular system; central nervous system; hypochord; notochord; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in pulmonary valve stenosis. Orthologous to human IGFBP7 (insulin like growth factor binding protein 7).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

10 figures from 5 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:85888 (19 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 3 figures from Hooper et al., 2009
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With igfbp7 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		Retinal arterial macroaneurysm with supravalvular pulmonic stenosis	614224

Associated With igfbp7 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR000867	Insulin-like growth factor-binding protein, IGFBP
Domain	IPR002350	Kazal domain
Domain	IPR003598	Immunoglobulin subtype 2
Domain	IPR003599	Immunoglobulin domain subtype
Domain	IPR007110	Immunoglobulin-like domain
Family	IPR011390	Insulin-like growth factor binding protein-related protein (IGFBP-rP), MAC25
Homologous_superfamily	IPR009030	Growth factor receptor cysteine-rich domain superfamily
Homologous_superfamily	IPR013783	Immunoglobulin-like fold
Homologous_superfamily	IPR036058	Kazal domain superfamily
Homologous_superfamily	IPR036179	Immunoglobulin-like domain superfamily