Gene
st3gal3a
- ID
- ZDB-GENE-040426-1322
- Name
- ST3 beta-galactoside alpha-2,3-sialyltransferase 3a
- Symbol
- st3gal3a Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 6 Mapping Details/Browsers
- Description
- Predicted to enable N-acetyllactosaminide alpha-2,3-sialyltransferase activity. Predicted to be involved in protein glycosylation. Predicted to be located in Golgi membrane. Is expressed in several structures, including cardiovascular system; integument; liver; pleuroperitoneal region; and ventral mesoderm. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder 12 and developmental and epileptic encephalopathy 15. Orthologous to human ST3GAL3 (ST3 beta-galactoside alpha-2,3-sialyltransferase 3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:63978 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la025502Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa16072 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa16184 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa20610 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa26657 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa33791 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa33792 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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No data available
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| autosomal recessive intellectual developmental disorder 12 | Alliance | Intellectual developmental disorder, autosomal recessive 12 | 611090 |
| developmental and epileptic encephalopathy 15 | Alliance | Developmental and epileptic encephalopathy 15 | 615006 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Glycosyltransferase 29 | Glycosyl transferase family 29 | GT29-like superfamiliy | Sialyltransferase |
|---|---|---|---|---|---|---|
| UniProtKB:A0A8M9QF92 | InterPro | 385 | ||||
| UniProtKB:Q7T3B9 | InterPro | 358 | ||||
| UniProtKB:A0A8M9PLY0 | InterPro | 307 | ||||
| UniProtKB:A0A8M9PLX6 | InterPro | 401 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
st3gal3a-201
(1)
|
Ensembl | 1,887 nt | ||
| mRNA |
st3gal3a-202
(1)
|
Ensembl | 574 nt | ||
| mRNA |
st3gal3a-203
(1)
|
Ensembl | 898 nt | ||
| mRNA |
st3gal3a-204
(1)
|
Ensembl | 541 nt | ||
| mRNA |
st3gal3a-205
(1)
|
Ensembl | 1,119 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-215F22 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:63978 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_200355 (1) | 1934 nt | ||
| Genomic | GenBank:BX119315 (1) | 210930 nt | ||
| Polypeptide | UniProtKB:A0A8M9PLX6 (1) | 401 aa |
- Yamakawa, N., Vanbeselaere, J., Chang, L.Y., Yu, S.Y., Ducrocq, L., Harduin-Lepers, A., Kurata, J., Aoki-Kinoshita, K.F., Sato, C., Khoo, K.H., Kitajima, K., Guerardel, Y. (2018) Systems glycomics of adult zebrafish identifies organ-specific sialylation and glycosylation patterns. Nature communications. 9:4647
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Petit, D., Teppa, E., Mir, A., Vicogne, D., Thisse, C., Thisse, B., Filloux, C., Harduin-Lepers, A. (2015) Integrative view of α2,3-sialyltransferases (ST3Gal) molecular and functional evolution in deuterostomes: significance of lineage specific losses. Mol. Biol. Evol.. 32(4):906-27
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
- Vanbeselaere, J., Chang, L.Y., Harduin-Lepers, A., Fabre, E., Yamakawa, N., Slomianny, C., Biot, C., Khoo, K.H., and Guerardel, Y. (2012) Mapping the expressed glycome and glycosyltransferases of zebrafish liver cells as a relevant model system for glycosylation studies. Journal of Proteome Research. 11(4):2164-2177
- Harduin-Lepers, A. (2010) Comprehensive Analysis of sialyltransferases in vertebrate genomes.. Glycobiology. 2010:2:29-61
- Wang, D., Jao, L.E., Zheng, N., Dolan, K., Ivey, J., Zonies, S., Wu, X., Wu, K., Yang, H., Meng, Q., Zhu, Z., Zhang, B., Lin, S., and Burgess, S.M. (2007) Efficient genome-wide mutagenesis of zebrafish genes by retroviral insertions. Proceedings of the National Academy of Sciences of the United States of America. 104(30):12428-12433
- Harduin-Lepers, A., Mollicone, R., Delannoy, P., and Oriol, R. (2005) The animal sialyltransferases and sialyltransferase-related genes: a phylogenetic approach. Glycobiology. 15(8):805-817
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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