Gene

st3gal3a

ID

ZDB-GENE-040426-1322

Name

ST3 beta-galactoside alpha-2,3-sialyltransferase 3a

Symbol

st3gal3a Nomenclature History

Previous Names

siat6 (1)
st3ga3-r (1)
st3gal3-r2 (1)
st3gal3
SIAT6-r (1)
zgc:63978

Type

protein_coding_gene

Location

Chr: 6 Mapping Details/Browsers

Description

Predicted to have N-acetyllactosaminide alpha-2,3-sialyltransferase activity. Predicted to be involved in protein glycosylation. Predicted to localize to Golgi apparatus and integral component of membrane. Human ortholog(s) of this gene implicated in autosomal recessive non-syndromic intellectual disability and early infantile epileptic encephalopathy 15. Is expressed in axial vasculature; liver; mucus secreting cell; and ventral mesoderm. Orthologous to human ST3GAL3 (ST3 beta-galactoside alpha-2,3-sialyltransferase 3).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

3 figures from 3 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:63978 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With st3gal3a Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
autosomal recessive intellectual developmental disorder 12	Alliance	Intellectual developmental disorder, autosomal recessive 12	611090
developmental and epileptic encephalopathy 15	Alliance	Developmental and epileptic encephalopathy 15	615006

Associated With st3gal3a Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Family	IPR001675	Glycosyl transferase family 29
Family	IPR012163	Sialyltransferase
Family	IPR051142	Glycosyltransferase 29
Homologous_superfamily	IPR038578	GT29-like superfamiliy

Domain Details Per Protein

Protein	Length	Glycosyltransferase 29	Glycosyl transferase family 29	GT29-like superfamiliy	Sialyltransferase
UniProtKB:A0A8M9QF92 InterPro	385
UniProtKB:Q7T3B9 InterPro	358
UniProtKB:A0A8M9PLY0 InterPro	307
UniProtKB:A0A8M9PLX6 InterPro	401

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	st3gal3a-201 (1) Ensembl	Ensembl	1,887 nt	Select Tool
mRNA	st3gal3a-202 (1) Ensembl	Ensembl	574 nt	Select Tool
mRNA	st3gal3a-203 (1) Ensembl	Ensembl	898 nt	Select Tool
mRNA	st3gal3a-204 (1) Ensembl	Ensembl	541 nt	Select Tool
mRNA	st3gal3a-205 (1) Ensembl	Ensembl	1,119 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations