Gene

fus

ID
ZDB-GENE-040426-1010
Name
FUS RNA binding protein
Symbol
fus Nomenclature History
Previous Names
  • zgc:56390 (1)
Type
protein_coding_gene
Location
Chr: 3 Mapping Details/Browsers
Description
Predicted to have RNA binding activity and transcription coregulator activity. Involved in axon extension. Predicted to localize to nucleus. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis; amyotrophic lateral sclerosis type 6; essential tremor 4; liposarcoma; and neurodegenerative disease. Is expressed in brain; eye; hindbrain; somite; and spinal cord. Orthologous to human FUS (FUS RNA binding protein).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
13 figures from 5 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
14 figures from 5 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Allele Type Localization Consequence Mutagen Supplier
gi7Allele with one deletionUnknownUnknownTALEN
mz2749Allele with one deletionUnknownUnknownCRISPR
sa15506Allele with one point mutationUnknownPremature StopENU
sa33220Allele with one point mutationUnknownPremature StopENU
sa40098Allele with one point mutationUnknownSplice SiteENU
1 - 5 of 5
Show
Sequence Targeting Reagents
Human Disease
Associated With fus Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
amyotrophic lateral sclerosis type 6 Alliance Amyotrophic lateral sclerosis 6, with or without frontotemporal dementia 608030
essential tremor 4 Alliance Essential tremor, hereditary, 4 614782
1 - 2 of 2
Associated With fus Via Experimental Models
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR000504 RNA recognition motif domain
Domain IPR001876 Zinc finger, RanBP2-type
Family IPR034870 TAF15/EWS/TLS family
Homologous_superfamily IPR012677 Nucleotide-binding alpha-beta plait domain superfamily
Homologous_superfamily IPR035979 RNA-binding domain superfamily
1 - 5 of 6 Show all
Domain Details Per Protein
Protein Length Nucleotide-binding alpha-beta plait domain superfamily RNA-binding domain superfamily RNA recognition motif domain TAF15/EWS/TLS family Zinc finger, RanBP2-type Zinc finger, RanBP2-type superfamily
UniProtKB:F1R0M4 541
1 - 1 of 1
Transcripts
Genome Browsers
Genome Build: GRCz11Chromosome: 3
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA fus-201 (1) Ensembl 2,094 nt
ncRNA fus-002 (1) Ensembl 872 nt
1 - 2 of 2
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab1-fus monoclonal IgG1 Mouse
BD Biosciences
2
1 - 1 of 1
Plasmids
No data available
Constructs
No data available
Marker Relationships
Relationship Marker Type Marker Accession Numbers Citations
Contained inBACDKEY-16L2ZFIN Curated Data
EncodescDNAMGC:174074ZFIN Curated Data
Has ArtifactcDNAMGC:56390ZFIN Curated Data
1 - 3 of 3
Show
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Species Symbol Chromosome Accession # Evidence
HumanFUS16
Conserved genome location (synteny) (1)
Functional complementation (1)
Nucleotide sequence comparison (1)
Amino acid sequence comparison (3)
MouseFus7
Conserved genome location (synteny) (1)
Amino acid sequence comparison (2)
Citations
1 - 10 of 21
Show