Gene
fus
- ID
- ZDB-GENE-040426-1010
- Name
- FUS RNA binding protein
- Symbol
- fus Nomenclature History
- Previous Names
-
- zgc:56390 (1)
- Type
- protein_coding_gene
- Location
- Chr: 3 Mapping Details/Browsers
- Description
- Predicted to have RNA binding activity and transcription coregulator activity. Involved in axon extension. Predicted to localize to nucleus. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis; amyotrophic lateral sclerosis type 6; essential tremor 4; liposarcoma; and neurodegenerative disease. Is expressed in brain; eye; hindbrain; somite; and spinal cord. Orthologous to human FUS (FUS RNA binding protein).
- Genome Resources
- Note
- None
- Comparative Information
- All Expression Data
- 13 figures from 5 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 14 figures from 5 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Allele | Type | Localization | Consequence | Mutagen | Supplier |
---|---|---|---|---|---|
gi7 | Allele with one deletion | Unknown | Unknown | TALEN | |
mz2749 | Allele with one deletion | Unknown | Unknown | CRISPR | |
sa15506 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
sa33220 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
sa40098 | Allele with one point mutation | Unknown | Splice Site | ENU |
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Human Disease
Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
---|---|---|---|
amyotrophic lateral sclerosis type 6 | Alliance | Amyotrophic lateral sclerosis 6, with or without frontotemporal dementia | 608030 |
essential tremor 4 | Alliance | Essential tremor, hereditary, 4 | 614782 |
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Human Disease | Fish | Conditions | Citations |
---|---|---|---|
amyotrophic lateral sclerosis | fussa15506/sa15506 | standard conditions | Bourefis et al., 2020 |
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Domain, Family, and Site Summary
Type | InterPro ID | Name |
---|---|---|
Domain | IPR000504 | RNA recognition motif domain |
Domain | IPR001876 | Zinc finger, RanBP2-type |
Family | IPR034870 | TAF15/EWS/TLS family |
Homologous_superfamily | IPR012677 | Nucleotide-binding alpha-beta plait domain superfamily |
Homologous_superfamily | IPR035979 | RNA-binding domain superfamily |
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Domain Details Per Protein
Protein | Length | Nucleotide-binding alpha-beta plait domain superfamily | RNA-binding domain superfamily | RNA recognition motif domain | TAF15/EWS/TLS family | Zinc finger, RanBP2-type | Zinc finger, RanBP2-type superfamily |
---|---|---|---|---|---|---|---|
UniProtKB:F1R0M4
|
541 |
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Interactions and Pathways
No data available
Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
---|---|---|---|---|---|---|---|
Ab1-fus | monoclonal | IgG1 | Mouse |
|
BD Biosciences
|
2 |
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Plasmids
No data available
No data available
Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | DKEY-16L2 | ZFIN Curated Data | |
Encodes | cDNA | MGC:174074 | ZFIN Curated Data | |
Has Artifact | cDNA | MGC:56390 | ZFIN Curated Data |
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Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:NM_201083 (1) | 2045 nt | ||
Genomic | GenBank:BX571714 (1) | 240105 nt | ||
Polypeptide | UniProtKB:F1R0M4 (1) | 541 aa |
- Aksoy, Y.A., Cole, A.J., Deng, W., Hesselson, D. (2024) Zebrafish CCNF and FUS Mediate Stress-Specific Motor Responses. Cells. 13(5):
- Quelle-Regaldie, A., Folgueira, M., Yáñez, J., Sobrido-Cameán, D., Alba-González, A., Barreiro-Iglesias, A., Sobrido, M.J., Sánchez, L. (2022) A nop56 Zebrafish Loss-of-Function Model Exhibits a Severe Neurodegenerative Phenotype. Biomedicines. 10(8)
- Don, E.K., Maschirow, A., Radford, R.A.W., Scherer, N.M., Vidal-Itriago, A., Hogan, A., Maurel, C., Formella, I., Stoddart, J.J., Hall, T.E., Lee, A., Shi, B., Cole, N.J., Laird, A.S., Badrock, A.P., Chung, R.S., Morsch, M. (2021) In vivo Validation of Bimolecular Fluorescence Complementation (BiFC) to Investigate Aggregate Formation in Amyotrophic Lateral Sclerosis (ALS). Molecular neurobiology. 58(5):2061-2074
- Bourefis, A.R., Campanari, M.L., Buee-Scherrer, V., Kabashi, E. (2020) Functional characterization of a FUS mutant zebrafish line as a novel genetic model for ALS. Neurobiology of disease. 142:104935
- Campanari, M.L., Bourefis, A.R., Buee-Scherrer, V., Kabashi, E. (2020) Freezing activity brief data from a new FUS mutant zebrafish line. Data in brief. 31:105921
- Xiao, Y., Chen, J., Wan, Y., Gao, Q., Jing, N., Zheng, Y., Zhu, X. (2019) Regulation of zebrafish dorsoventral patterning by phase separation of RNA-binding protein Rbm14. Cell discovery. 5:37
- Laboissonniere, L.A., Smith, C.L., Mesenbrink, J., Chowdhury, R., Burney, A., Lang, M., Sierra, M., Stark, A., Maldonado-Casalduc, G., Muller, M., Trimarchi, J.M. (2018) ALS-associated genes display CNS expression in the developing zebrafish. Gene expression patterns : GEP. 30:14-31
- Chitramuthu, B.P., Kay, D.G., Bateman, A., Bennett, H.P. (2017) Neurotrophic effects of progranulin in vivo in reversing motor neuron defects caused by over or under expression of TDP-43 or FUS. PLoS One. 12:e0174784
- Lebedeva, S., de Jesus Domingues, A.M., Butter, F., Ketting, R.F. (2017) Characterization of genetic loss-of-function of Fus in zebrafish. RNA Biology. 14(1):29-35
- Wu, Y., Su, G., Tang, S., Liu, W., Ma, Z., Zheng, X., Liu, H., Yu, H. (2017) The combination of in silico and in vivo approaches for the investigation of disrupting effects of tris (2-chloroethyl) phosphate (TCEP) toward core receptors of zebrafish. Chemosphere. 168:122-130
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