Gene

fus

ID

ZDB-GENE-040426-1010

Name

FUS RNA binding protein

Symbol

fus Nomenclature History

Previous Names

zgc:56390 (1)

Type

protein_coding_gene

Location

Chr: 3 Mapping Details/Browsers

Description

Predicted to have RNA binding activity and transcription coregulator activity. Involved in axon extension. Predicted to localize to nucleus. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis; amyotrophic lateral sclerosis type 6; essential tremor 4; liposarcoma; and neurodegenerative disease. Is expressed in brain; eye; hindbrain; somite; and spinal cord. Orthologous to human FUS (FUS RNA binding protein).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

13 figures from 5 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 14 figures from 5 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With fus Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
amyotrophic lateral sclerosis type 6	Alliance	Amyotrophic lateral sclerosis 6, with or without frontotemporal dementia	608030
essential tremor 4	Alliance	Essential tremor, hereditary, 4	614782

Associated With fus Via Experimental Models

Human Disease	Fish	Conditions	Citations
amyotrophic lateral sclerosis	fus^{sa15506/sa15506}	standard conditions	Bourefis et al., 2020

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR000504	RNA recognition motif domain
Domain	IPR001876	Zinc finger, RanBP2-type
Family	IPR034870	TAF15/EWS/TLS family
Homologous_superfamily	IPR012677	Nucleotide-binding alpha-beta plait domain superfamily
Homologous_superfamily	IPR035979	RNA-binding domain superfamily
Homologous_superfamily	IPR036443	Zinc finger, RanBP2-type superfamily

Domain Details Per Protein

Protein	Length	Nucleotide-binding alpha-beta plait domain superfamily	RNA-binding domain superfamily	RNA recognition motif domain	TAF15/EWS/TLS family	Zinc finger, RanBP2-type	Zinc finger, RanBP2-type superfamily
UniProtKB:F1R0M4 InterPro	541

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	fus-201 (1) Ensembl	Havana	2094 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
ncRNA	fus-002 (1) Ensembl	Havana	872 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Interactions and Pathways

No data available

Antibodies

Name	Type	Antigen Genes	Isotype	Host Organism	Assay	Source	Citations
Ab1-fus	monoclonal	fus	IgG1	Mouse		BD Biosciences	2

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations