Gene

fus

ID
ZDB-GENE-040426-1010
Name
FUS RNA binding protein
Symbol
fus Nomenclature History
Previous Names
  • zgc:56390 (1)
Type
protein_coding_gene
Location
Chr: 3 Mapping Details/Browsers
Description
Predicted to enable RNA binding activity and transcription coregulator activity. Acts upstream of or within axon extension. Predicted to be active in nucleus. Is expressed in gut; muscle; nervous system; and trunk. Used to study amyotrophic lateral sclerosis. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis; amyotrophic lateral sclerosis type 6; essential tremor 4; liposarcoma; and neurodegenerative disease. Orthologous to human FUS (FUS RNA binding protein).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
12 figures from 5 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
14 figures from 5 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With fus Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
amyotrophic lateral sclerosis type 6 Alliance Amyotrophic lateral sclerosis 6, with or without frontotemporal dementia 608030
essential tremor 4 Alliance Essential tremor, hereditary, 4 614782
Associated With fus Via Experimental Models
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR000504 RNA recognition motif domain
Domain IPR001876 Zinc finger, RanBP2-type
Family IPR034459 RNA-binding protein FUS
Family IPR034870 TAF15/EWS/TLS family
Homologous_superfamily IPR012677 Nucleotide-binding alpha-beta plait domain superfamily
Homologous_superfamily IPR035979 RNA-binding domain superfamily
Homologous_superfamily IPR036443 Zinc finger, RanBP2-type superfamily
Domain Details Per Protein
Protein Length Nucleotide-binding alpha-beta plait domain superfamily RNA-binding domain superfamily RNA-binding protein FUS RNA recognition motif domain TAF15/EWS/TLS family Zinc finger, RanBP2-type Zinc finger, RanBP2-type superfamily
UniProtKB:F1Q8G6 230
UniProtKB:A0A2R8QJ67 527
UniProtKB:A0A2R8RX88 519
UniProtKB:B0JZI7 237
UniProtKB:A0A0R4IDV1 218
UniProtKB:F1R0M4 541
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab1-fus monoclonal IgG1 Mouse
BD Biosciences
2
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations