ZFIN is now using GRCz12tu for Genomic Data
Gene
abat
- ID
- ZDB-GENE-031006-4
- Name
- 4-aminobutyrate aminotransferase
- Symbol
- abat Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 3 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable pyridoxal phosphate binding activity. Predicted to be involved in GABA catabolic process. Predicted to be located in cytoplasm. Predicted to be active in mitochondrion. Is expressed in blood; liver; nervous system; pronephric duct; and yolk syncytial layer. Human ortholog(s) of this gene implicated in Alzheimer's disease; GABA aminotransferase deficiency; and Huntington's disease. Orthologous to human ABAT (4-aminobutyrate aminotransferase).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 7 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb880 (9 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| GABA aminotransferase deficiency | Alliance | GABA-transaminase deficiency | 613163 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR049704 | Aminotransferases class-III pyridoxal-phosphate attachment site |
| Family | IPR004631 | 4-aminobutyrate aminotransferase, eukaryotic |
| Family | IPR005814 | Aminotransferase class-III |
| Homologous_superfamily | IPR015421 | Pyridoxal phosphate-dependent transferase, major domain |
| Homologous_superfamily | IPR015422 | Pyridoxal phosphate-dependent transferase, small domain |
| Homologous_superfamily | IPR015424 | Pyridoxal phosphate-dependent transferase |
Domain Details Per Protein
| Protein | Additional Resources | Length | 4-aminobutyrate aminotransferase, eukaryotic | Aminotransferase class-III | Aminotransferases class-III pyridoxal-phosphate attachment site | Pyridoxal phosphate-dependent transferase | Pyridoxal phosphate-dependent transferase, major domain | Pyridoxal phosphate-dependent transferase, small domain |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:I3IRW7 | InterPro | 500 | ||||||
| UniProtKB:A0AC58IH31 | InterPro | 500 | ||||||
| UniProtKB:A0AC58IH34 | InterPro | 500 | ||||||
| UniProtKB:A0AC58IH68 | InterPro | 500 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers