Gene

idh1

ID
ZDB-GENE-031006-1
Name
isocitrate dehydrogenase (NADP(+)) 1
Symbol
idh1 Nomenclature History
Previous Names
  • cb876 (1)
  • fm90e09
  • im:7143416
  • wu:fm90e09 (1)
Type
protein_coding_gene
Location
Chr: 9 Mapping Details/Browsers
Description
Predicted to have isocitrate dehydrogenase (NADP+) activity. Involved in hemopoiesis. Predicted to localize to cytosol; mitochondrion; and peroxisome. Human ortholog(s) of this gene implicated in acute myeloid leukemia; glioblastoma multiforme; hepatocellular clear cell carcinoma; malignant glioma; and myelodysplastic syndrome. Is expressed in several structures, including digestive system; ectoderm; mesoderm; nervous system; and pronephric duct. Orthologous to human IDH1 (isocitrate dehydrogenase (NADP(+)) 1).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
17 figures from 5 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
2 figures from Shi et al., 2015
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With idh1 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
{Glioma, susceptibility to, somatic} 137800
Associated With idh1 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR019818 Isocitrate/isopropylmalate dehydrogenase, conserved site
Domain IPR024084 Isopropylmalate dehydrogenase-like domain
Family IPR004790 Isocitrate dehydrogenase NADP-dependent
Domain Details Per Protein
Protein Length Isocitrate dehydrogenase NADP-dependent Isocitrate/isopropylmalate dehydrogenase, conserved site Isopropylmalate dehydrogenase-like domain
UniProtKB:A0A8M2BF40 415
UniProtKB:Q802Y2 429
Transcripts
Genome Browsers
No data available
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations