Gene
add1
- ID
- ZDB-GENE-030909-2
- Name
- adducin 1 (alpha)
- Symbol
- add1 Nomenclature History
- Previous Names
-
- cb787 (1)
- zgc:158352
- Type
- protein_coding_gene
- Location
- Chr: 21 Mapping Details/Browsers
- Description
- Predicted to enable actin filament binding activity. Predicted to be involved in barbed-end actin filament capping; positive regulation of adherens junction organization; and positive regulation of establishment of endothelial barrier. Predicted to be active in several cellular components, including adherens junction; cytoskeleton; and postsynaptic density. Is expressed in nervous system and pronephric duct. Human ortholog(s) of this gene implicated in IgA glomerulonephritis; artery disease (multiple); familial combined hyperlipidemia; and gastroschisis. Orthologous to human ADD1 (adducin 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 17 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb787 (8 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| bj1Gt | Transgenic insertion | Unknown | Unknown | DNA | |
| la021946Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa9003 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa9196 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa37206 | Allele with one point mutation | Unknown | Splice Site | ENU |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| essential hypertension | Alliance | {Hypertension, essential, salt-sensitive} | 145500 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Aldolase class II Adducin subfamily | Class II aldolase/adducin N-terminal | Class II aldolase/adducin N-terminal domain superfamily |
|---|---|---|---|---|---|
| UniProtKB:A1A5X4 | InterPro | 741 | |||
| UniProtKB:A0A8M9PTW3 | InterPro | 690 | |||
| UniProtKB:A0A8M9P3B6 | InterPro | 763 | |||
| UniProtKB:A0A8M3ATI8 | InterPro | 698 | |||
| UniProtKB:A0A8M2B847 | InterPro | 783 | |||
| UniProtKB:A0A8M9PQH2 | InterPro | 732 | |||
| UniProtKB:A0A8M2B7V9 | InterPro | 729 | |||
| UniProtKB:A0A8M9PQG8 | InterPro | 848 |
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | RP71-1H20 | ||
| Encodes | EST | cb787 | Thisse et al., 2001 | |
| Encodes | EST | fu40b10 | Rauch et al., 2003 | |
| Encodes | cDNA | MGC:158352 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001079958 (1) | 2984 nt | ||
| Genomic | GenBank:AL627305 (1) | 150276 nt | ||
| Polypeptide | UniProtKB:A0A8M9PQG8 (1) | 848 aa |
- Yang, S., Cao, S., Xu, X., Li, Q., Li, J., Guo, J., Wang, F., Bao, Y., Jiang, Z., Zhang, T., Wang, L., Sun, S. (2023) adducin 1 is essential for the survival of erythroid precursors via regulating p53 transcription in zebrafish. iScience. 26:107516107516
- Lee, H.J., Hou, Y., Maeng, J.H., Shah, N.M., Chen, Y., Lawson, H.A., Yang, H., Yue, F., Wang, T. (2022) Epigenomic analysis reveals prevalent contribution of transposable elements to cis-regulatory elements, tissue-specific expression, and alternative promoters in zebrafish. Genome research. 32(7):1424-1436
- Chen, R.Y., Lin, C.J., Liang, S.T., Villalobos, O., Villaflores, O.B., Lou, B., Lai, Y.H., Hsiao, C.D. (2020) UVB Irradiation Induced Cell Damage and Early Onset of Junbb Expression in Zebrafish. Animals : an open access journal from MDPI. 10(6):
- Zhang, C., Zhang, Q., Wang, J., Tian, J., Song, Y., Xie, H., Chang, M., Nie, P., Gao, Q., Zou, J. (2019) Transcriptomic responses of S100 family to bacterial and viral infection in zebrafish. Fish & shellfish immunology. 94:685-696
- Moore, C., Richens, J.L., Hough, Y., Ucanok, D., Malla, S., Sang, F., Chen, Y., Elworthy, S., Wilkinson, R.N., Gering, M. (2018) Gfi1aa and Gfi1b set the pace for primitive erythroblast differentiation from hemangioblasts in the zebrafish embryo. Blood advances. 2:2589-2606
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Tang, V., Cofer, Z.C., Cui, S., Sapp, V., Loomes, K.M., Matthews, R.P. (2016) Loss of a Candidate Biliary Atresia Susceptibility Gene, add3a, Causes Biliary Developmental Defects in Zebrafish. Journal of pediatric gastroenterology and nutrition. 63(5):524-530
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
- Gallagher, T.L., Arribere, J.A., Geurts, P.A., Exner, C.R., McDonald, K.L., Dill, K.K., Marr, H.L., Adkar, S.S., Garnett, A.T., Amacher, S.L., and Conboy, J.G. (2011) Rbfox-regulated alternative splicing is critical for zebrafish cardiac and skeletal muscle functions. Developmental Biology. 359(2):251-61
- Wotton, K.R., Weierud, F.K., Dietrich, S., and Lewis, K.E. (2008) Comparative genomics of Lbx loci reveals conservation of identical Lbx ohnologs in bony vertebrates. BMC Evolutionary Biology. 8:171
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