Gene

mvp

ID

ZDB-GENE-030826-33

Name

major vault protein

Symbol

mvp Nomenclature History

Previous Names

cb771 (1)
wu:fb52b05
wu:fc02g01

Type

protein_coding_gene

Location

Chr: 3 Mapping Details/Browsers

Description

Involved in brain development; eye development; and neuron projection regeneration. Predicted to localize to cytoplasm and nucleus. Human ortholog(s) of this gene implicated in mitral valve prolapse. Is expressed in several structures, including digestive system; hatching gland; nervous system; periderm; and polster. Orthologous to human MVP (major vault protein).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

10 figures from 4 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

cb771 (15 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 2 figures from Blaker-Lee et al., 2012
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With mvp Human Ortholog

No data available

Associated With mvp Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR021870	Major vault protein, shoulder domain
Domain	IPR040989	Major vault protein repeat domain 3
Domain	IPR041134	Major vault protein repeat domain 2
Domain	IPR041136	Major vault protein repeat domain 4
Domain	IPR041139	Major vault protein repeat domain
Family	IPR039059	Major vault protein
Homologous_superfamily	IPR036013	Band 7/SPFH domain superfamily
Homologous_superfamily	IPR043023	Major vault protein repeat domain superfamily
Homologous_superfamily	IPR043179	Major vault protein repeat domain 2 superfamily
Repeat	IPR002499	Major vault protein, N-terminal