Gene
kdm7aa
- ID
- ZDB-GENE-030131-9829
- Name
- lysine (K)-specific demethylase 7Aa
- Symbol
- kdm7aa Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 4 Mapping Details/Browsers
- Description
- Enables histone H3K27me2/H3K27me3 demethylase activity and histone H3K9 demethylase activity. Involved in midbrain development. Acts upstream of or within chromatin remodeling. Predicted to be located in nucleus. Is expressed in several structures, including anterior axial hypoblast; immature eye; margin; mesoderm; and nervous system. Human ortholog(s) of this gene implicated in melanoma. Orthologous to human KDM7A (lysine demethylase 7A).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 14 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb414 (18 images)
- IMAGE:7139974 (6 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR019786 | Zinc finger, PHD-type, conserved site |
| Domain | IPR001965 | Zinc finger, PHD-type |
| Domain | IPR003347 | JmjC domain |
| Domain | IPR019787 | Zinc finger, PHD-finger |
| Domain | IPR041070 | Jumonji, helical domain |
| Family | IPR050690 | JHDM1 Histone Demethylase |
| Homologous_superfamily | IPR011011 | Zinc finger, FYVE/PHD-type |
Domain Details Per Protein
| Protein | Additional Resources | Length | JHDM1 Histone Demethylase | JmjC domain | Jumonji, helical domain | Zinc finger, FYVE/PHD-type | Zinc finger, PHD-finger | Zinc finger, PHD-type | Zinc finger, PHD-type, conserved site |
|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A2R8RKB3 | InterPro | 837 | |||||||
| UniProtKB:Q5RHD1 | InterPro | 875 | |||||||
| UniProtKB:A0AB32TQ99 | InterPro | 831 |
- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
kdm7aa-201
(1)
|
Ensembl | 1,848 nt | ||
| mRNA |
kdm7aa-202
(1)
|
Ensembl | 841 nt | ||
| mRNA |
kdm7aa-203
(1)
|
Ensembl | 2,628 nt | ||
| mRNA |
kdm7aa-204
(1)
|
Ensembl | 3,094 nt |
Interactions and Pathways
No data available
Plasmids
No data available