Gene

rspo3

ID

ZDB-GENE-030131-9814

Name

R-spondin 3

Symbol

rspo3 Nomenclature History

Previous Names

cb387 (1)
sb:cb387
wu:fa13e08
zgc:162040

Type

protein_coding_gene

Location

Chr: 16 Mapping Details/Browsers

Description

Predicted to have heparin binding activity. Involved in negative regulation of Wnt signaling pathway involved in dorsal/ventral axis specification; negative regulation of canonical Wnt signaling pathway involved in neural plate anterior/posterior pattern formation; and posterior lateral line neuromast development. Predicted to localize to extracellular region. Is expressed in several structures, including digestive system; endoderm; forebrain neural keel; nervous system; and presumptive telencephalon. Orthologous to human RSPO3 (R-spondin 3).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

12 figures from 7 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

cb387 (12 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 10 figures from 4 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With rspo3 Human Ortholog

No data available

Associated With rspo3 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR043601	R-spondin, Fu-CRD domain
Domain	IPR044004	Spondin-like TSP1 domain
Homologous_superfamily	IPR009030	Growth factor receptor cysteine-rich domain superfamily
Homologous_superfamily	IPR036383	Thrombospondin type-1 (TSP1) repeat superfamily
Repeat	IPR000884	Thrombospondin type-1 (TSP1) repeat
Repeat	IPR006212	Furin-like repeat

Domain Details Per Protein

Protein	Length	Furin-like repeat	Growth factor receptor cysteine-rich domain superfamily	R-spondin, Fu-CRD domain	Spondin-like TSP1 domain	Thrombospondin type-1 (TSP1) repeat	Thrombospondin type-1 (TSP1) repeat superfamily
UniProtKB:A0A8M2B4I7 InterPro	248
UniProtKB:Q5R328 InterPro	317

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	rspo3-201 (1) Ensembl	Havana	2194 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
ncRNA	rspo3-002 (1) Ensembl	Havana	629 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations