Gene
relb
- ID
- ZDB-GENE-030131-9531
- Name
- v-rel avian reticuloendotheliosis viral oncogene homolog B
- Symbol
- relb Nomenclature History
- Previous Names
-
- fj85b02
- wu:fj85b02
- Type
- protein_coding_gene
- Location
- Chr: 15 Mapping Details/Browsers
- Description
- Predicted to have DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II regulatory region sequence-specific DNA binding activity; and chromatin binding activity. Predicted to be involved in several processes, including innate immune response; intracellular signal transduction; and regulation of transcription by RNA polymerase II. Predicted to localize to I-kappaB/NF-kappaB complex; cytosol; and nucleoplasm. Human ortholog(s) of this gene implicated in breast cancer and primary immunodeficiency disease. Orthologous to human RELB (RELB proto-oncogene, NF-kB subunit).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Diotel et al., 2015
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| immunodeficiency 53 | Alliance | ?Immunodeficiency 53 | 617585 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR030492 | Rel homology domain, conserved site |
| Domain | IPR002909 | IPT domain |
| Domain | IPR011539 | Rel homology domain, DNA-binding domain |
| Domain | IPR032397 | Rel homology dimerisation domain |
| Family | IPR000451 | NF-kappa-B/Dorsal |
| Homologous_superfamily | IPR008967 | p53-like transcription factor, DNA-binding domain superfamily |
| Homologous_superfamily | IPR013783 | Immunoglobulin-like fold |
| Homologous_superfamily | IPR014756 | Immunoglobulin E-set |
| Homologous_superfamily | IPR037059 | Rel homology domain (RHD), DNA-binding domain superfamily |
Domain Details Per Protein
| Protein | Length | Immunoglobulin E-set | Immunoglobulin-like fold | IPT domain | NF-kappa-B/Dorsal | p53-like transcription factor, DNA-binding domain superfamily | Rel homology dimerisation domain | Rel homology domain, conserved site | Rel homology domain, DNA-binding domain | Rel homology domain (RHD), DNA-binding domain superfamily |
|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M9P750
|
590 | |||||||||
|
UniProtKB:A0A8M9PC94
|
573 | |||||||||
|
UniProtKB:A0A8M1Q745
|
590 |
Interactions and Pathways
No data available
Plasmids
No data available