PUBLICATION

Comprehensive expression map of transcription regulators in the adult zebrafish telencephalon reveals distinct neurogenic niches

Authors
Diotel, N., Viales, R.R., Armant, O., März, M., Ferg, M., Rastegar, S., Strähle, U.
ID
ZDB-PUB-150106-14
Date
2015
Source
The Journal of comparative neurology   523(8): 1202-21 (Journal)
Registered Authors
Armant, Olivier, Diotel, Nicolas, Rastegar, Sepand, Strähle, Uwe
Keywords
none
MeSH Terms
  • Animals
  • Animals, Genetically Modified
  • Atlases as Topic
  • Gene Expression
  • Immunohistochemistry
  • In Situ Hybridization
  • Neural Stem Cells/metabolism*
  • Telencephalon/anatomy & histology
  • Telencephalon/metabolism*
  • Transcription Factors/metabolism*
  • Zebrafish/anatomy & histology
  • Zebrafish/metabolism*
  • Zebrafish Proteins/metabolism*
PubMed
25556858 Full text @ J. Comp. Neurol.
Abstract
The zebrafish has become a model to study adult vertebrate neurogenesis. In particular, the adult telencephalon has been an intensely studied structure in the zebrafish brain. Differential expression of transcriptional regulators (TRs) is a key feature of development and tissue homeostasis. Here we report an expression map of 1,202 TR genes in the telencephalon of adult zebrafish. Our results are summarized in a database with search and clustering functions to identify genes expressed in particular regions of the telencephalon. We classified 562 genes into 13 distinct patterns, including genes expressed in the proliferative zone. The remaining 640 genes displayed unique and complex patterns of expression and could thus not be grouped into distinct classes. The neurogenic ventricular regions express overlapping but distinct sets of TR genes, suggesting regional differences in the neurogenic niches in the telencephalon. In summary, the small telencephalon of the zebrafish shows a remarkable complexity in TR gene expression. This article is protected by copyright. All rights reserved.
Genes / Markers
Figures
Show all Figures
Expression
Phenotype
Mutation and Transgenics
Human Disease / Model Data
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Mapping
Errata and Notes