Gene
alox5ap
- ID
- ZDB-GENE-030131-9322
- Name
- arachidonate 5-lipoxygenase-activating protein
- Symbol
- alox5ap Nomenclature History
- Previous Names
-
- Flap (1)
- wu:fj65d02
- zgc:63982
- Type
- protein_coding_gene
- Location
- Chr: 10 Mapping Details/Browsers
- Description
- Predicted to have glutathione peroxidase activity; glutathione transferase activity; and leukotriene-C4 synthase activity. Involved in angiogenesis. Predicted to localize to endoplasmic reticulum and nuclear envelope. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); asthma; brain infarction (multiple); breast cancer; and cerebral palsy. Orthologous to human ALOX5AP (arachidonate 5-lipoxygenase activating protein).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
---|---|---|---|
cerebral infarction | Alliance | {Stroke, susceptibility to} | 601367 |
Domain, Family, and Site Summary
Type | InterPro ID | Name |
---|---|---|
Family | IPR001129 | Membrane-associated, eicosanoid/glutathione metabolism (MAPEG) protein |
Family | IPR001446 | 5-lipoxygenase-activating protein |
Family | IPR050997 | Membrane-associated proteins in eicosanoid and glutathione metabolism |
Homologous_superfamily | IPR023352 | Membrane associated eicosanoid/glutathione metabolism-like domain superfamily |
Domain Details Per Protein
Protein | Length | 5-lipoxygenase-activating protein | Membrane associated eicosanoid/glutathione metabolism-like domain superfamily | Membrane-associated, eicosanoid/glutathione metabolism (MAPEG) protein | Membrane-associated proteins in eicosanoid and glutathione metabolism |
---|---|---|---|---|---|
UniProtKB:F1QKS8
|
156 |
Type | Name | Annotation Method | Length (nt) | Analysis |
---|---|---|---|---|
mRNA |
alox5ap-201
(1)
|
Havana | 1304 nt |
Interactions and Pathways
No data available
Plasmids
No data available