Gene

grna

ID

ZDB-GENE-030131-8434

Name

granulin a

Symbol

grna Nomenclature History

Previous Names

grn
pgrn-a (1)
progranulin (1)
sb:eu337
wu:fb11g12
wu:fj18f05
zfPGRN-A (1)

Type

protein_coding_gene

Location

Chr: 3 Mapping Details/Browsers

Description

Acts upstream of or within several processes, including neuron differentiation; sensory system development; and skeletal muscle acetylcholine-gated channel clustering. Predicted to be active in extracellular region. Is expressed in several structures, including digestive system; hematopoietic system; immature eye; nervous system; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in dementia (multiple); neurodegenerative disease (multiple); neuronal ceroid lipofuscinosis 11; and primary progressive multiple sclerosis. Orthologous to human GRN (granulin precursor).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

16 figures from 9 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

eu337 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 19 figures from 6 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With grna Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
Grn-related frontotemporal lobar degeneration with Tdp43 inclusions	Alliance	Aphasia, primary progressive	607485
Grn-related frontotemporal lobar degeneration with Tdp43 inclusions	Alliance	Frontotemporal dementia 2	607485
neuronal ceroid lipofuscinosis 11	Alliance	Ceroid lipofuscinosis, neuronal, 11	614706

Associated With grna Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR000118	Granulin
Family	IPR039036	Granulin family
Homologous_superfamily	IPR037277	Granulin superfamily

Domain Details Per Protein

Protein	Additional Resources	Length
UniProtKB:A0A8M2BB97	InterPro	1138
UniProtKB:A0A8M9PEV4	InterPro	968
UniProtKB:A0A8M2BB61	InterPro	880
UniProtKB:A0A8M2BB98	InterPro	1053
UniProtKB:Q8QGN9	InterPro PDB	873
UniProtKB:A0A8M3B8B0	InterPro	1141
UniProtKB:A0A8M3AQX2	InterPro	1056
UniProtKB:A0A8M2BB46	InterPro	1053
UniProtKB:E9QI45	InterPro	1049

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	grna-201 (1) Ensembl	Ensembl	3,631 nt	Select Tool ZFIN BLAST
mRNA	grna-202 (1) Ensembl	Ensembl	4,160 nt	Select Tool ZFIN BLAST
mRNA	grna-203 (1) Ensembl	Ensembl	3,632 nt	Select Tool ZFIN BLAST
mRNA	grna-204 (1) Ensembl	Ensembl	567 nt	Select Tool ZFIN BLAST
mRNA	grna-205 (1) Ensembl	Ensembl	840 nt	Select Tool ZFIN BLAST
mRNA	grna-206 (1) Ensembl	Ensembl	545 nt	Select Tool ZFIN BLAST
mRNA	grna-207 (1) Ensembl	Ensembl	440 nt	Select Tool ZFIN BLAST
ncRNA	grna-007 (1) Ensembl	Ensembl	835 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

Name	Type	Antigen Genes	Isotype	Host Organism	Assay	Citations
Ab3-grna	polyclonal	grna		Mouse		1
Ab1-grna	polyclonal	grna		Rabbit	IHC WB	1
Ab2-grna	monoclonal	grna	IgG2b	Rat		1

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations