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ZIRC
ZFIN ID: ZDB-GENE-030131-8434
Gene Name: granulin a
Gene Symbol: grna
Sequence Ontology ID : SO:0000704

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Previous Names: grn, pgrn-a (1), progranulin (1), sb:eu337, wu:fb11g12, wu:fj18f05, zfPGRN-A (1)

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(Including Attributions)
Location: Chr: 3 Mapping Details/Browsers
Nomenclature History
AUTOMATED DESCRIPTION
Involved in axon extension; liver development; and skeletal muscle acetylcholine-gated channel clustering. Human ortholog(s) of this gene implicated in dementia (multiple); neurodegenerative disease  ...
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
mde33 Small Deletion Exon 3 Unknown ZINC_FINGER_NUCLEASE
  • European Zebrafish Resource Center (EZRC) (order this)
  • mde54a Small Deletion Exon 3 Unknown ZINC_FINGER_NUCLEASE
  • European Zebrafish Resource Center (EZRC) (order this)
  • mde54b Small Deletion Exon 3 Unknown ZINC_FINGER_NUCLEASE
  • European Zebrafish Resource Center (EZRC) (order this)
  • mde54c Indel Exon 3 Unknown ZINC_FINGER_NUCLEASE
  • European Zebrafish Resource Center (EZRC) (order this)
  • sa6034 Point Mutation Unknown Premature Stop ENU
    sa20026 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa33188 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa38396 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Targeting reagents:
    DISEASE ASSOCIATED WITH grna HUMAN ORTHOLOG
    Disease Ontology Term OMIM Term OMIM Phenotype ID
    Grn-related frontotemporal lobar degeneration with Tdp43 inclusions Aphasia, primary progressive 607485
    Frontotemporal lobar degeneration with ubiquitin-positive inclusions 607485
    neuronal ceroid lipofuscinosis 11 Ceroid lipofuscinosis, neuronal, 11 614706
    DISEASE ASSOCIATED WITH grna VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process axon extension (more)
    GO Terms (all 3)
    TRANSCRIPTS
    Type Name Length (bp) Analysis
    ncRNA grna-007 (1) 835
    mRNA grna-202 (1) 4160
    grna-203 (1) 3632
    grna-204 (1) 567
    grna-205 (1) 840
    grna-206 (1) 545
    grna-207 (1) 440
    GENE PRODUCT DESCRIPTION No description available
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    PLASMIDSNo data available
    CONSTRUCTS WITH SEQUENCES FROM grna
    MARKER RELATIONSHIPS
    grnaContained in: [BAC] DKEY-151M15 (1) (order this), DKEY-197M10 (1) (order this)
    grnaEncodes: [EST] eu337 (1), fb11g12, fj18f05 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001001949 (1) 3649bp
    Genomic GenBank:BX901883 (1) 241961bp Blast at MegaBLAST
    Polypeptide UniProtKB:E9QI45 (1) 1049aa
    Sequence Clusters UniGene:67637 (1)
    Sequence Information (all 42)
    ORTHOLOGY for grna (Chr: 3)
    CITATIONS (37)