Gene

atl1

ID
ZDB-GENE-030131-8003
Name
atlastin GTPase 1
Symbol
atl1 Nomenclature History
Previous Names
  • fj46c01
  • wu:fj46c01
Type
protein_coding_gene
Location
Chr: 13 Mapping Details/Browsers
Description
Predicted to have GTP binding activity and GTPase activity. Involved in determination of dorsal identity and negative regulation of BMP signaling pathway. Localizes to late endosome. Human ortholog(s) of this gene implicated in hereditary sensory neuropathy type 1D and hereditary spastic paraplegia 3A. Is expressed in brain; primary motor neurons; and spinal cord neural tube. Orthologous to human ATL1 (atlastin GTPase 1).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
3 figures from 2 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
4 figures from 2 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With atl1 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
hereditary sensory neuropathy type 1D Alliance Neuropathy, hereditary sensory, type ID 613708
hereditary spastic paraplegia 3A Alliance Spastic paraplegia 3A, autosomal dominant 182600
Associated With atl1 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR015894 Guanylate-binding protein, N-terminal
Domain IPR030386 GB1/RHD3-type guanine nucleotide-binding (G) domain
Homologous_superfamily IPR027417 P-loop containing nucleoside triphosphate hydrolase
Homologous_superfamily IPR036543 Guanylate-binding protein, C-terminal domain superfamily
Domain Details Per Protein
Protein Length GB1/RHD3-type guanine nucleotide-binding (G) domain Guanylate-binding protein, C-terminal domain superfamily Guanylate-binding protein, N-terminal P-loop containing nucleoside triphosphate hydrolase
UniProtKB:B8A6H1 554
UniProtKB:E9QGX9 559
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab1-atl1 polyclonal IgG Goat
  • WB
Santa Cruz Biotechnology, Inc.
2
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations