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ZIRC
ZFIN ID: ZDB-GENE-030131-8003
Gene Name: atlastin GTPase 1
Gene Symbol: atl1    Nomenclature History

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Previous Names: fj46c01, wu:fj46c01

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 13 Mapping Details/Browsers
Description: Predicted to have GTP binding activity and GTPase activity. Involved in determination of dorsal identity and negative regulation of BMP signaling pathway. Localizes to the late endosome. Human ortholog(s) of this gene implicated in hereditary sensory neuropathy type 1D and hereditary spastic paraplegia 3A. Is expressed in brain; primary motor neurons; and spinal cord neural tube. Orthologous to human ATL1 (atlastin GTPase 1).
Genome Resources: Alliance (1),  Gene:571909 (1),  Ensembl(GRCz11):ENSDARG00000060481 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa95 Point Mutation Unknown Unknown ENU
sa5865 Point Mutation Unknown Splice Site ENU
sa24941 Point Mutation Unknown Splice Site ENU
sa42256 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-atl1 N/A 2
    MO2-atl1 N/A 1
    MO3-atl1 N/A 1
    DISEASE ASSOCIATED WITH atl1 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    hereditary sensory neuropathy type 1D Alliance Neuropathy, hereditary sensory, type ID 613708
    hereditary spastic paraplegia 3A Alliance Spastic paraplegia 3A, autosomal dominant 182600
    DISEASE ASSOCIATED WITH atl1 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process determination of dorsal identity (more)
    Cellular Component late endosome (more)
    Molecular Function GTPase activity (more)
    GO Terms (all 10)
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA atl1-202 (1)    Ensembl 2156
    atl1-203 (1)    Ensembl 407
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    Name Type Isotype Host Organism Assay Source Publications
    Ab1-atl1 polyclonal IgG Goat WB Santa Cruz Biotechnology, Inc.
    2
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM atl1 No data available
    MARKER RELATIONSHIPS
    atl1 Contained in: [BAC] CH211-282C13 (1) (order this)
    atl1 Encodes: [EST] fj46c01
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001145700 (1) 2156 bp
    Genomic GenBank:BX936452 (1) 136110 bp
    Select Tool
    Polypeptide UniProtKB:E9QGX9 (1) 559 aa
    Sequence Clusters UniGene:81075 (1)
    Sequence Information (all 13)
    ORTHOLOGY for atl1 ( Chr: 13 )
    CITATIONS (24)