Gene
castor2
- ID
- ZDB-GENE-030131-5505
- Name
- cytosolic arginine sensor for mTORC1 subunit 2
- Symbol
- castor2 Nomenclature History
- Previous Names
-
- gats
- gatsl2
- sb:cb509
- wu:fc27d10
- wu:fd20f09
- wu:fe01c02
- zgc:55700
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Description
- Predicted to be involved in cellular response to L-arginine and negative regulation of TORC1 signaling. Predicted to be located in cytoplasm. Predicted to be active in cytosol. Is expressed in artery; blood; notochord; and yolk syncytial layer. Orthologous to several human genes including CASTOR2 (cytosolic arginine sensor for mTORC1 subunit 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 6 figures from Thisse et al., 2001
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb509 (12 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR027795 | CASTOR, ACT domain |
| Domain | IPR040778 | CASTOR1, N-terminal |
| Domain | IPR049479 | Cytosolic arginine sensor for mTORC1 subunit 1/2, ACT-like |
| Family | IPR026249 | CASTOR family |
| Family | IPR051719 | Cytosolic arginine sensor for mTORC1 |
| Homologous_superfamily | IPR045865 | ACT-like domain |
Domain Details Per Protein
| Protein | Additional Resources | Length | ACT-like domain | CASTOR1, N-terminal | CASTOR, ACT domain | CASTOR family | Cytosolic arginine sensor for mTORC1 | Cytosolic arginine sensor for mTORC1 subunit 1/2, ACT-like |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q7ZVS6 | InterPro | 329 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
castor2-201
(1)
|
Ensembl | 3,197 nt |
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-209A2 | ZFIN Curated Data | |
| Contained in | BAC | DKEYP-36F5 | ZFIN Curated Data | |
| Encodes | EST | cb509 | ZFIN Curated Data | |
| Encodes | EST | fc27d10 | ZFIN Curated Data | |
| Encodes | EST | fd20f09 | ||
| Encodes | EST | fe01c02 | ZFIN Curated Data | |
| Encodes | EST | tdsubc_2b3 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:55700 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:66173 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_199780 (1) | 3210 nt | ||
| Genomic | GenBank:BX294180 (1) | 69889 nt | ||
| Polypeptide | UniProtKB:Q7ZVS6 (1) | 329 aa |
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Woods, I.G., Wilson, C., Friedlander, B., Chang, P., Reyes, D.K., Nix, R., Kelly, P.D., Chu, F., Postlethwait, J.H., and Talbot, W.S. (2005) The zebrafish gene map defines ancestral vertebrate chromosomes. Genome research. 15(9):1307-1314
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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