Gene
tpte
- ID
- ZDB-GENE-030131-5503
- Name
- transmembrane phosphatase with tensin homology
- Symbol
- tpte Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 10 Mapping Details/Browsers
- Description
- Exhibits ion channel activity and phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity. Involved in phosphatidylinositol dephosphorylation. Predicted to localize to integral component of membrane. Is expressed in blood vessel; pleuroperitoneal region; and ventral mesoderm. Orthologous to several human genes including TPTE2 (transmembrane phosphoinositide 3-phosphatase and tensin homolog 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 11 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:6902478 (7 images)
Wild Type Expression Summary
- All Phenotype Data
- 3 figures from Ratanayotha et al., 2022
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR016130 | Protein-tyrosine phosphatase, active site |
| Domain | IPR000387 | Tyrosine-specific protein phosphatases domain |
| Domain | IPR003595 | Protein-tyrosine phosphatase, catalytic |
| Domain | IPR005821 | Ion transport domain |
| Domain | IPR014020 | Tensin phosphatase, C2 domain |
| Domain | IPR029023 | Tensin-type phosphatase domain |
| Domain | IPR045102 | TPTE, protein tyrosine phosphatase-like catalytic domain |
| Family | IPR051281 | Dual-specificity lipid and protein phosphatase |
| Homologous_superfamily | IPR027359 | Voltage-dependent channel domain superfamily |
| Homologous_superfamily | IPR029021 | Protein-tyrosine phosphatase-like |
| Homologous_superfamily | IPR035892 | C2 domain superfamily |
Domain Details Per Protein
| Protein | Length | C2 domain superfamily | Dual-specificity lipid and protein phosphatase | Ion transport domain | Protein-tyrosine phosphatase, active site | Protein-tyrosine phosphatase, catalytic | Protein-tyrosine phosphatase-like | Tensin phosphatase, C2 domain | Tensin-type phosphatase domain | TPTE, protein tyrosine phosphatase-like catalytic domain | Tyrosine-specific protein phosphatases domain | Voltage-dependent channel domain superfamily |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:Q4V9E4
|
511 | |||||||||||
|
UniProtKB:F1QG29
|
511 |
Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab1-tpte | monoclonal | IgG2a | Mouse |
|
UC Davis/NIH NeuroMab Facility
|
2 |
Plasmids