ZFIN ID: ZDB-GENE-030131-5503
Gene Name: transmembrane phosphatase with tensin homology
Gene Symbol: tpte    Nomenclature History

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Previous Names: Dr-VSP (1), tpip (1), wu:fd20e11, wu:fi24b06

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 10 Mapping Details/Browsers
Description: Exhibits ion channel activity and phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity. Involved in phosphatidylinositol dephosphorylation. Predicted to localize to cytosol and integral component of membrane. Is expressed in blood vessel; pleuroperitoneal region; and ventral mesoderm. Orthologous to several human genes including TPTE2 (transmembrane phosphoinositide 3-phosphatase and tensin homolog 2).
Genome Resources: Alliance (1),  Gene:327292 (1),  Ensembl(GRCz11):ENSDARG00000056985 (2)
GENE EXPRESSION
All Expression Data: 7 figures from 2 publications
Directly Submitted Expression Data: 6 figures (7 images) from Thisse et al., 2004 [IMAGE:6902478]
Wild-type Stages, Structures: Segmentation:1-4 somites (10.33h-11.66h) to Adult (90d-730d, breeding adult)
 
High Throughput Expression: GEO (1) Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa41660 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH tpte HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH tpte VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process phosphatidylinositol dephosphorylation (more)
    Cellular Component integral component of membrane (more)
    Molecular Function ion channel activity (more)
    GO Terms (all 19)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA tpte-201 (1)    Ensembl 2446
    ncRNA tpte-002 (1)    Ensembl 571
    tpte-003 (1)    Ensembl 538
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    CONSTRUCTS WITH SEQUENCES FROM tpte No data available
    MARKER RELATIONSHIPS
    tpte Contained in: [BAC] CH211-287A12 (1)
    tpte Encodes: [EST] fd20e11, fi24b06 (1), IMAGE:6902478 (1)
    [cDNA] MGC:113432 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001025458 (1) 2135 nt
    Genomic GenBank:AL928852 (1) 157466 nt
    Select Tool
    Polypeptide UniProtKB:B3IUN7 (1) 511 aa
    Sequence Information (all 21)
    ORTHOLOGY for tpte ( Chr: 10 )
    CITATIONS (33)