Gene
parp1
- ID
- ZDB-GENE-030131-3955
- Name
- poly (ADP-ribose) polymerase 1
- Symbol
- parp1 Nomenclature History
- Previous Names
-
- si:dkey-206f10.3
- wu:fc60f12
- zgc:110092
- Type
- protein_coding_gene
- Location
- Chr: 20 Mapping Details/Browsers
- Description
- Predicted to have NAD+ ADP-ribosyltransferase activity and protein ADP-ribosylase activity. Predicted to be involved in double-strand break repair and protein poly-ADP-ribosylation. Predicted to localize to nucleolus. Human ortholog(s) of this gene implicated in several diseases, including arthritis; asthma; bacterial meningitis; neurodegenerative disease (multiple); and stomach carcinoma. Orthologous to human PARP1 (poly(ADP-ribose) polymerase 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 4 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR001357 | BRCT domain |
| Domain | IPR001510 | Zinc finger, PARP-type |
| Domain | IPR004102 | Poly(ADP-ribose) polymerase, regulatory domain |
| Domain | IPR008893 | WGR domain |
| Domain | IPR012317 | Poly(ADP-ribose) polymerase, catalytic domain |
| Domain | IPR012982 | PARP1-like, PADR1 domain, zinc ribbon fold |
| Domain | IPR049296 | PARP1-like, PADR1 domain, N-terminal helical subdomain |
| Family | IPR008288 | Poly [ADP-ribose] polymerase |
| Homologous_superfamily | IPR036420 | BRCT domain superfamily |
| Homologous_superfamily | IPR036616 | Poly(ADP-ribose) polymerase, regulatory domain superfamily |
| Homologous_superfamily | IPR036930 | WGR domain superfamily |
| Homologous_superfamily | IPR036957 | Zinc finger, PARP-type superfamily |
| Homologous_superfamily | IPR038650 | PADR1, C-terminal domain superfamily |
Domain Details Per Protein
| Protein | Length | BRCT domain | BRCT domain superfamily | PADR1, C-terminal domain superfamily | PARP1-like, PADR1 domain, N-terminal helical subdomain | PARP1-like, PADR1 domain, zinc ribbon fold | Poly [ADP-ribose] polymerase | Poly(ADP-ribose) polymerase, catalytic domain | Poly(ADP-ribose) polymerase, regulatory domain | Poly(ADP-ribose) polymerase, regulatory domain superfamily | WGR domain | WGR domain superfamily | Zinc finger, PARP-type | Zinc finger, PARP-type superfamily |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8N1TQ38
|
1013 | |||||||||||||
|
UniProtKB:Q5RHR0
|
1013 |
Interactions and Pathways
No data available
Plasmids
No data available