Gene
zeb1b
- ID
- ZDB-GENE-010621-1
- Name
- zinc finger E-box binding homeobox 1b
- Symbol
- zeb1b Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 12 Mapping Details/Browsers
- Description
- Predicted to have DNA binding activity and metal ion binding activity. Involved in gastrulation; regulation of cell motility; and regulation of cell-cell adhesion involved in gastrulation. Predicted to localize to nucleus. Human ortholog(s) of this gene implicated in Fuchs' endothelial dystrophy and posterior polymorphous corneal dystrophy 3. Is expressed in several structures, including cranial ganglion; hypoblast; neural plate; pharyngeal arch; and segmental plate. Orthologous to human ZEB1 (zinc finger E-box binding homeobox 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 11 figures from 6 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu530 (16 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Fuchs' endothelial dystrophy | Alliance | Corneal dystrophy, Fuchs endothelial, 6 | 613270 |
| posterior polymorphous corneal dystrophy 3 | Alliance | Corneal dystrophy, posterior polymorphous, 3 | 609141 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Drought induced 19 protein type, zinc-binding domain | Homeobox domain | Homeobox-like domain superfamily | Zinc finger C2H2 superfamily | Zinc finger C2H2-type |
|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M9QE24
|
1064 | |||||
|
UniProtKB:Q9DEH7
|
1078 |
Interactions and Pathways
No data available
Plasmids
No data available