ZFIN ID: ZDB-PUB-080209-4
Members of the miRNA-200 Family Regulate Olfactory Neurogenesis
Choi, P.S., Zakhary, L., Choi, W.Y., Caron, S., Alvarez-Saavedra, E., Miska, E.A., McManus, M., Harfe, B., Giraldez, A.J., Horvitz, R.H., Schier, A.F., and Dulac, C.
Date: 2008
Source: Neuron   57(1): 41-55 (Journal)
Registered Authors: Caron, Sophie, Choi, Wen-Yee, Giraldez, Antonio, Schier, Alexander
Keywords: none
MeSH Terms:
  • Age Factors
  • Animals
  • Cell Differentiation/physiology*
  • Cell Proliferation*
  • Embryo, Nonmammalian
  • Embryonic Stem Cells/physiology
  • Gene Expression Profiling
  • Gene Expression Regulation, Developmental/physiology
  • Mice
  • MicroRNAs/classification
  • MicroRNAs/physiology*
  • Nerve Tissue Proteins/genetics
  • Nerve Tissue Proteins/metabolism
  • Neurons/physiology*
  • Olfactory Pathways/cytology*
  • Olfactory Pathways/physiology
  • Oligonucleotide Array Sequence Analysis
  • Zebrafish
PubMed: 18184563 Full text @ Neuron
MicroRNAs (miRNAs) are highly expressed in vertebrate neural tissues, but the contribution of specific miRNAs to the development and function of different neuronal populations is still largely unknown. We report that miRNAs are required for terminal differentiation of olfactory precursors in both mouse and zebrafish but are dispensable for proper function of mature olfactory neurons. The repertoire of miRNAs expressed in olfactory tissues contains over 100 distinct miRNAs. A subset, including the miR-200 family, shows high olfactory enrichment and expression patterns consistent with a role during olfactory neurogenesis. Loss of function of the miR-200 family phenocopies the terminal differentiation defect observed in absence of all miRNA activity in olfactory progenitors. Our data support the notion that vertebrate tissue differentiation is controlled by conserved subsets of organ-specific miRNAs in both mouse and zebrafish and provide insights into control mechanisms underlying olfactory differentiation in vertebrates.