PUBLICATION
Specification of jaw muscle identity in zebrafish: correlation with engrailed-homeoprotein expression
- Authors
- Hatta, K., Schilling, T.F., BreMiller, R.A., and Kimmel, C.B.
- ID
- ZDB-PUB-961014-422
- Date
- 1990
- Source
- Science (New York, N.Y.) 250: 802-805 (Journal)
- Registered Authors
- BreMiller, Ruth, Hatta, Kohei, Kimmel, Charles B., Schilling, Tom
- Keywords
- none
- MeSH Terms
-
- Gene Expression Regulation*
- Genes, Homeobox*
- Motor Neurons/cytology
- Morphogenesis
- Jaw/embryology*
- Animals
- Cell Differentiation
- Zebrafish/embryology*
- DNA-Binding Proteins/blood*
- Muscles/embryology*
- Muscles/innervation
- Muscles/metabolism
- PubMed
- 1978412 Full text @ Science
Citation
Hatta, K., Schilling, T.F., BreMiller, R.A., and Kimmel, C.B. (1990) Specification of jaw muscle identity in zebrafish: correlation with engrailed-homeoprotein expression. Science (New York, N.Y.). 250:802-805.
Abstract
Molecules that determine the specific features of individual muscles in vertebrates are unknown. Antibody labeling studies described here revealed a molecular difference among muscles in the zebrafish head, in that two functionally related jaw muscles (the levator arcus palatini and the dilator operculi), and not other head muscles, expressed engrailed-homeodomain proteins. Expression began in mesoderm-derived muscle-precursor cells in the paraxial mesenchyme and continued during muscle morphogenesis and differentiation. Growth cones of trigeminal motoneurons that innervate these muscles associated with the precursors within a few hours of the time they began to express engrailed. It is proposed that the engrailed proteins in these cells establish muscle identity and neuromuscular target recognition.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping