header logo image header logo text
Downloads Login
Research
General Information
ZIRC
ZFIN ID: ZDB-PERS-960805-501
Schilling, Tom
Email: tschilli@uci.edu
URL: http://devcell.bio.uci.edu/tschilling/
Affiliation: Schilling Lab
Address: Department of Developmental and Cell Biology School of Biological Sciences University of California, Irvine Irvine, CA 92697-2300 USA
Country: United States
Phone: (949) 824-2479
Fax: (949) 824-4709
Orcid ID:


BIOGRAPHY AND RESEARCH INTERESTS


PUBLICATIONS
Sharma, P., MacLean, A.L., Meinecke, L., Clouthier, D., Nie, Q., Schilling, T.F. (2018) Transcriptomics reveals complex kinetics of dorsal-ventral patterning gene expression in the mandibular arch. Genesis (New York, N.Y. : 2000). 57(1):e23275
Meinecke, L., Sharma, P.P., Du, H., Zhang, L., Nie, Q., Schilling, T.F. (2018) Modeling craniofacial development reveals spatiotemporal constraints on robust patterning of the mandibular arch. PLoS Computational Biology. 14:e1006569
Subramanian, A., Kanzaki, L.F., Galloway, J.L., Schilling, T.F. (2018) Mechanical force regulates tendon extracellular matrix organization and tenocyte morphogenesis through TGFbeta signaling. eLIFE. 7:
Vorontsova, I., Gehring, I., Hall, J.E., Schilling, T.F. (2018) Aqp0a Regulates Suture Stability in the Zebrafish Lens. Investigative ophthalmology & visual science. 59:2869-2879
Rackauckas, C., Schilling, T., Nie, Q. (2018) Mean-Independent Noise Control of Cell Fates via Intermediate States. iScience. 3:11-20
Aguillon, R., Batut, J., Subramanian, A., Madelaine, R., Dufourcq, P., Schilling, T.F., Blader, P. (2018) Cell-type heterogeneity in the early zebrafish olfactory epithelium is generated from progenitors within preplacodal ectoderm. eLIFE. 7
Vibert, L., Aquino, G., Gehring, I., Subkhankulova, T., Schilling, T.F., Rocco, A., Kelsh, R.N. (2017) An ongoing role for Wnt signaling in differentiating melanocytes in vivo. Pigment cell & melanoma research. 30(2):219-232
Wang, Q., Holmes, W.R., Sosnik, J., Schilling, T., Nie, Q. (2017) Cell Sorting and Noise-Induced Cell Plasticity Coordinate to Sharpen Boundaries between Gene Expression Domains. PLoS Computational Biology. 13:e1005307
Muto, A., Schilling, T.F. (2017) Zebrafish as a Model to Study Cohesin and Cohesinopathies. Methods in molecular biology (Clifton, N.J.). 1515:177-196
Nichols, J.T., Blanco-Sánchez, B., Brooks, E.P., Parthasarathy, R., Dowd, J., Subramanian, A., Nachtrab, G., Poss, K.D., Schilling, T.F., Kimmel, C.B. (2016) Ligament versus bone cell identity in the zebrafish hyoid skeleton is regulated by mef2ca. Development (Cambridge, England). 143(23):4430-4440
Kawauchi, S., Santos, R., Muto, A., Lopez-Burks, M.E., Schilling, T.F., Lander, A.D., Calof, A.L. (2016) Using mouse and zebrafish models to understand the etiology of developmental defects in Cornelia de Lange Syndrome. American journal of medical genetics. Part C, Seminars in medical genetics. 172(2):138-45
Sosnik, J., Zheng, L., Rackauckas, C.V., Digman, M., Gratton, E., Nie, Q., Schilling, T.F. (2016) Noise modulation in retinoic acid signaling sharpens segmental boundaries of gene expression in the embryonic zebrafish hindbrain. eLIFE. 5:e14034
Schilling, T.F., Sosnik, J., Nie, Q. (2016) Visualizing retinoic acid morphogen gradients. Methods in cell biology. 133:139-163
Cruz, I.A., Kappedal, R., Mackenzie, S.M., Hailey, D.W., Hoffman, T.L., Schilling, T.F., Raible, D.W. (2015) Robust regeneration of adult zebrafish lateral line hair cells reflects continued precursor pool maintenance. Developmental Biology. 402(2):229-38
Boer, E.F., Howell, E.D., Schilling, T.F., Jette, C.A., Stewart, R.A. (2015) Fascin1-Dependent Filopodia are Required for Directional Migration of a Subset of Neural Crest Cells. PLoS Genetics. 11:e1004946
Le Pabic, P., Ng, C., Schilling, T.F. (2014) Fat-Dachsous Signaling Coordinates Cartilage Differentiation and Polarity during Craniofacial Development. PLoS Genetics. 10:e1004726
Muto, A., Ikeda, S., Lopez-Burks, M.E., Kikuchi, Y., Calof, A.L., Lander, A.D., Schilling, T.F. (2014) Nipbl and Mediator Cooperatively Regulate Gene Expression to Control Limb Development. PLoS Genetics. 10:e1004671
Alexander, C., Piloto, S., Le Pabic, P., Schilling, T.F. (2014) Wnt signaling interacts with bmp and edn1 to regulate dorsal-ventral patterning and growth of the craniofacial skeleton. PLoS Genetics. 10:e1004479
Subramanian, A., Schilling, T.F. (2014) Thrombospondin-4 controls matrix assembly during development and repair of myotendinous junctions. eLIFE. 6(8):e02372
Tuttle, A.M., Hoffman, T.L., Schilling, T.F. (2014) Rabconnectin-3a regulates vesicle endocytosis and canonical Wnt signaling in zebrafish neural crest migration. PLoS Biology. 12:e1001852
Clemens, D.M., Németh-Cahalan, K.L., Trinh, L., Zhang, T., Schilling, T.F., and Hall, J.E. (2013) In vivo Analysis of Aquaporin 0 Function in Zebrafish: Permeability Regulation is Required for Lens Transparency. Investigative ophthalmology & visual science. 54(7):5136-5143
Wu, B., Piloto, S., Zeng, W., Hoverter, N.P., Schilling, T.F., and Waterman, M.L. (2013) Ring Finger Protein 14 is a new regulator of TCF/β‐catenin‐mediated transcription and colon cancer cell survival. EMBO reports. 14(4):347-55
Cai, A.Q., Radtke, K., Linville, A., Lander, A.D., Nie, Q., and Schilling, T.F. (2012) Cellular retinoic acid-binding proteins are essential for hindbrain patterning and signal robustness in zebrafish. Development (Cambridge, England). 139(12):2150-2155
de Pater, E., Ciampricotti, M., Priller, F., Veerkamp, J., Strate, I., Smith, K., Lagendijk, A.K., Schilling, T.F., Herzog, W., Abdelilah-Seyfried, S., Hammerschmidt, M., and Bakkers, J. (2012) Bmp Signaling Exerts Opposite Effects on Cardiac Differentiation. Circulation research. 110(4):578-587
Nguyen-Chi, M.E., Bryson-Richardson, R., Sonntag, C., Hall, T.E., Gibson, A., Sztal, T., Chua, W., Schilling, T.F., and Currie, P.D. (2012) Morphogenesis and Cell Fate Determination within the Adaxial Cell Equivalence Group of the Zebrafish Myotome. PLoS Genetics. 8(10):e1003014
Zhang, L., Radtke, K., Zheng, L., Cai, A.Q., Schilling, T.F., and Nie, Q. (2012) Noise drives sharpening of gene expression boundaries in the zebrafish hindbrain. Molecular Systems Biology. 8:613
Alexander, C., Zuniga, E., Blitz, I.L., Wada, N., Le Pabic, P., Javidan, Y., Zhang, T., Cho, K.W., Crump, J.G., and Schilling, T.F. (2011) Combinatorial roles for BMPs and Endothelin 1 in patterning the dorsal-ventral axis of the craniofacial skeleton. Development (Cambridge, England). 138(23):5135-5146
Zuniga, E., Rippen, M., Alexander, C., Schilling, T.F., and Crump, J.G. (2011) Gremlin 2 regulates distinct roles of BMP and Endothelin 1 signaling in dorsoventral patterning of the facial skeleton. Development (Cambridge, England). 138(23):5147-5156
Muto, A., Calof, A.L., Lander, A.D., and Schilling, T.F. (2011) Multifactorial Origins of Heart and Gut Defects in nipbl-Deficient Zebrafish, a Model of Cornelia de Lange Syndrome. PLoS Biology. 9(10):e1001181
Clouthier, D.E., Garcia, E., and Schilling, T.F. (2010) Regulation of facial morphogenesis by endothelin signaling: Insights from mice and fish. American journal of medical genetics. 152A(12):2962-2973
Froger, A., Clemens, D.M., Kalman, K., Németh-Cahalan, K.L., Schilling, T.F., and Hall, J.E. (2010) Two Distinct Aquaporin 0s are Required for Development and Transparency of the Zebrafish Lens. Investigative ophthalmology & visual science. 51(12):6582-6592
Piloto, S., and Schilling, T.F. (2010) Ovo1 links Wnt signaling with N-cadherin localization during neural crest migration. Development (Cambridge, England). 137(12):1981-1990
Schilling, T.F., Le Pabic, P., and Hoffman, T.L. (2010) Using transgenic zebrafish (Danio rerio) to study development of the craniofacial skeleton. Zeitschrift fur angewandte Ichthyologie = Journal of applied ichthyology. 26(2):183-186
Schilling, T.F., and Le Pabic, P. (2009) Fishing for the signals that pattern the face. Journal of biology. 8(11):101
Linville, A., Radtke, K., Waxman, J.S., Yelon, D., and Schilling, T.F. (2009) Combinatorial roles for zebrafish retinoic acid receptors in the hindbrain, limbs and pharyngeal arches. Developmental Biology. 325(1):60-70
Nair, S., and Schilling, T.F. (2008) Chemokine Signaling Controls Endodermal Migration During Zebrafish Gastrulation. Science (New York, N.Y.). 322(5898):89-92
Currie, P.D., Schilling, T.F., and Ingham, P.W. (2008) Small-scale marker-based screening for mutations in zebrafish development (2008). Methods in molecular biology (Clifton, N.J.). 461:493-512
White, R.J., Nie, Q., Lander, A.D., and Schilling, T.F. (2007) Complex Regulation of cyp26a1 Creates a Robust Retinoic Acid Gradient in the Zebrafish Embryo. PLoS Biology. 5(11):e304
Schilling, T.F., and Webb, J. (2007) Considering the zebrafish in a comparative context. Journal of experimental zoology. Part B, Molecular and developmental evolution. 308(5):515-522
Hoffman, T.L., Javier, A.L., Campeau, S.A., Knight, R.D., and Schilling, T.F. (2007) Tfap2 transcription factors in zebrafish neural crest development and ectodermal evolution. Journal of experimental zoology. Part B, Molecular and developmental evolution. 308(5):679-691
Bryson-Richardson, R.J., Berger, S., Schilling, T.F., Hall, T.E., Cole, N.J., Gibson, A.J., Sharpe, J., and Currie, P.D. (2007) FishNet: an online database of zebrafish anatomy. BMC Biology. 5(1):34
Plaster, N., Sonntag, C., Schilling, T.F., and Hammerschmidt, M. (2007) REREa/Atrophin-2 interacts with histone deacetylase and Fgf8 signaling to regulate multiple processes of zebrafish development. Developmental dynamics : an official publication of the American Association of Anatomists. 236(7):1891-1904
Luo, T., Xu, Y., Hoffman, T.L., Zhang, T., Schilling, T., and Sargent, T.D. (2007) Inca: a novel p21-activated kinase-associated protein required for cranial neural crest development. Development (Cambridge, England). 134(7):1279-1289
Nair, S., Li, W., Cornell, R., and Schilling, T.F. (2007) Requirements for Endothelin type-A receptors and Endothelin-1 signaling in the facial ectoderm for the patterning of skeletogenic neural crest cells in zebrafish. Development (Cambridge, England). 134(2):335-345
Webb, J.F. and Schilling, T.F. (2006) Zebrafish in Comparative Context: A Symposium. Integrative and Comparative Biology. 46(5):569-576
Stafford, D., White, R.J., Kinkel, M.D., Linville, A., Schilling, T.F., and Prince, V.E. (2006) Retinoids signal directly to zebrafish endoderm to specify insulin-expressing {beta}-cells. Development (Cambridge, England). 133(5):949-956
Knight, R.D., and Schilling, T.F. (2006) Cranial neural crest and development of the head skeleton. Advances in experimental medicine and biology. 589:120-133
Wada, N., Javidan, Y., Nelson, S., Carney, T.J., Kelsh, R.N., Schilling, T.F. (2005) Hedgehog signaling is required for cranial neural crest morphogenesis and chondrogenesis at the midline in the zebrafish skull. Development (Cambridge, England). 132(17):3977-3988
Holzschuh, J., Wada, N., Wada, C., Schaffer, A., Javidan, Y., Tallafuss, A., Bally-Cuif, L., and Schilling, T.F. (2005) Requirements for endoderm and BMP signaling in sensory neurogenesis in zebrafish. Development (Cambridge, England). 132(16):3731-3742
Knight, R.D., Javidan, Y., Zhang, T., Nelson, S., and Schilling, T.F. (2005) AP2-dependent signals from the ectoderm regulate craniofacial development in the zebrafish embryo. Development (Cambridge, England). 132(13):3127-3138
Norton, W.H., Mangoli, M., Lele, Z., Pogoda, H.M., Diamond, B., Mercurio, S., Russell, C., Teraoka, H., Stickney, H.L., Rauch, G.J., Heisenberg, C.P., Houart, C., Schilling, T.F., Frohnhoefer, H.G., Rastegar, S., Neumann, C.J., Gardiner, R.M., Strähle, U., Geisler, R., Rees, M., Talbot, W.S., and Wilson, S.W. (2005) Monorail/Foxa2 regulates floorplate differentiation and specification of oligodendrocytes, serotonergic raphe neurones and cranial motoneurones. Development (Cambridge, England). 132(4):645-658
Linville, A., Gumusaneli, E., Chandraratna, R.A., and Schilling, T.F. (2004) Independent roles for retinoic acid in segmentation and neuronal differentiation in the zebrafish hindbrain. Developmental Biology. 270(1):186-199
Clouthier, D.E., and Schilling, T.F. (2004) Understanding endothelin-1 function during craniofacial development in the mouse and zebrafish. Birth defects research. Part C, Embryo today : reviews. 72(2):190-199
Javidan, Y., and Schilling, T.F. (2004) Development of cartilage and bone. The Zebrafish: Cellular and Developmental Biology,2nd Ed. Methods Cell Biol.. 76:415-436
Knight, R.D., Javidan, Y., Nelson, S., Zhang, T., and Schilling, T. (2004) Skeletal and pigment cell defects in the lockjaw mutant reveal multiple roles for zebrafish tfap2a in neural crest development. Developmental dynamics : an official publication of the American Association of Anatomists. 229(1):87-98
Knight, R.D., Nair, S., Nelson, S.S., Afshar, A., Javidan, Y., Geisler, R., Rauch, G.J., and Schilling, T.F. (2003) lockjaw encodes a zebrafish tfap2a required for early neural crest development. Development (Cambridge, England). 130(23):5755-5768
Piotrowski, T., Ahn, D.-G., Schilling, T.F., Nair, S., Ruvinsky, I., Geisler, R., Rauch, G.-J., Haffter, P., Zon, L.I., Zhou, Y., Foott, H., Dawid, I.B., and Ho, R.K. (2003) The zebrafish van gogh mutation disrupts tbx1, which is involved in the DiGeorge deletion syndrome in humans. Development (Cambridge, England). 130(20):5043-5052
David, N.B., Saint-Etienne, L., Tsang, M., Schilling, T.F., and Rosa, F.M. (2002) Requirement for endoderm and FGF3 in ventral head skeleton formation. Development (Cambridge, England). 129(19):4457-4468
Yelick, P.C. and Schilling, T.F. (2002) Molecular dissection of craniofacial development using zebrafish. Critical reviews in oral biology and medicine : an official publication of the American Association of Oral Biologists. 13(4):308-322
Schilling, T.F., and Knight, R.D. (2001) Origins of anteroposterior patterning and Hox gene regulation during chordate evolution. Philosophical transactions of the Royal Society of London. Series B, Biological sciences. 356(1414):1599-1613
Begemann, G., Schilling, T.F., Rauch, G.J., Geisler, R., and Ingham, P.W. (2001) The zebrafish neckless mutation reveals a requirement for raldh2 in mesodermal signals that pattern the hindbrain. Development (Cambridge, England). 128(16):3081-3094
Schilling, T.F., Prince, V., and Ingham, P.W. (2001) Plasticity in zebrafish hox expression in the hindbrain and cranial neural crest. Developmental Biology. 229:201-216
Miller, C.T., Schilling, T.F., Lee, K., Parker, J., and Kimmel, C.B. (2000) sucker encodes a zebrafish Endothelin-1 required for ventral pharyngeal arch development. Development (Cambridge, England). 127(17):3815-3828
Brown, L.A., Rodaway, A.R.F., Schilling, T.F., Jowett, T., Ingham, P.W., Patient, R.K., and Sharrocks, A.D. (2000) Insights into early vasculogenesis revealed by expression of the ETS-domain transcription factor Fli-1 in wild-type and mutant zebrafish embryos. Mechanisms of Development. 90(2):237-252
Schilling, T.F., Concordet, J.-P., and Ingham, P.W. (1999) Regulation of left-right asymmetries in the zebrafish by Shh and BMP4. Developmental Biology. 210(2):277-287
Currie, P.D., Schilling, T.F., and Ingham, P.W. (1999) Small-scale marker-based screening for mutations in zebrafish development. Methods in molecular biology (Clifton, N.J.). 97:441-460
Brown, L.A., Amores, A., Schilling, T.F., Jowett, T., Baert, J.L., De Launoit, Y., and Sharrocks, A.D. (1998) Molecular characterization of the zebrafish PEA3 ETS-domain transcription factor. Oncogene. 17:93-104
Schilling, T.F. and Kimmel, C.B. (1997) Musculoskeletal patterning in the pharyngeal segments of the zebrafish embryo. Development (Cambridge, England). 124(15):2945-2960
Schilling, T.F. (1997) Genetic analysis of craniofacial development in the vertebrate embryo. BioEssays : news and reviews in molecular, cellular and developmental biology. 19(6):459-468
Piotrowski, T., Schilling, T.F., Brand, M., Jiang, Y.J., Heisenberg, C.P., Beuchle, D., Grandel, H., van Eeden, F.J., Furutani-Seiki, M., Granato, M., Haffter, P., Hammerschmidt, M., Kane, D.A., Kelsh, R.N., Mullins, M.C., Odenthal, J., Warga, R.M., and Nüsslein-Volhard, C. (1996) Jaw and branchial arch mutants in zebrafish. II. Anterior arches and cartilage differentiation. Development (Cambridge, England). 123:345-356
Schilling, T.F., Piotrowski, T., Grandel, H., Brand, M., Heisenberg, C.P., Jiang, Y.J., Beuchle, D., Hammerschmidt, M., Kane, D.A., Mullins, M.C., van Eeden, F.J., Kelsh, R.N., Furutani-Seiki, M., Granato, M., Haffter, P., Odenthal, J., Warga, R.M., Trowe, T., and Nüsslein-Volhard, C. (1996) Jaw and branchial arch mutants in zebrafish. I. Branchial arches. Development (Cambridge, England). 123:329-344
Schilling, T.F., Walker, C., and Kimmel, C.B. (1996) The chinless mutation and neural crest cell interactions in zebrafish jaw development. Development (Cambridge, England). 122:1417-1426
Kimmel, C.B., Ballard, W.W., Kimmel, S.R., Ullmann, B., and Schilling, T.F. (1995) Stages of embryonic development of the zebrafish. Developmental dynamics : an official publication of the American Association of Anatomists. 203:253-310
Schilling, T.F. and Kimmel, C.B. (1994) Segment and cell type lineage restrictions during pharyngeal arch development in the zebrafish embryo. Development (Cambridge, England). 120:483-494
Thisse, C., Thisse, B., Schilling, T.F., and Postlethwait, J.H. (1993) Structure of the zebrafish snail1 gene and its expression in wild-type, spadetail and no tail mutant embryos. Development (Cambridge, England). 119:1203-1215
Kimmel, C.B., Molven, A., Ellis, T.J., Hatta, K., Ho, R.K., Kane, D.A., Schilling, T.F., Walker, C., and Warga, R.M. (1993) Developmental and mutational analysis of body pattern formation: the zebrafish model. In Physiological and Biochemical Aspects of Fish Development, Walther-B-T. and Fyhn-H-J., eds., Bergen, Norway: University of Bergen Press. :22-29
Schilling, T.F. (1993) Cell lineage and mutational studies of cranial neural crest development in the zebrafish. Ph.D. Thesis.
Schilling, T.F., Walker, C., and Kimmel, C.B. (1991) Mutations that disrupt the development of cranial neural crest cells in the zebrafish. Soc. Neurosci. Abstr.. 17:924
Kimmel, C.B., Schilling, T.F., and Hatta, K. (1991) Patterning of body segments of the zebrafish embryo. Current topics in developmental biology. 25:77-110
Hatta, K., Schilling, T.F., BreMiller, R.A., and Kimmel, C.B. (1990) Specification of jaw muscle identity in zebrafish: correlation with engrailed-homeoprotein expression. Science (New York, N.Y.). 250:802-805
Kimmel, C.B., Warga, R.M., and Schilling, T.F. (1990) Origin and organization of the zebrafish fate map. Development (Cambridge, England). 108:581-594
Schilling, T.F., Hatta, K., Walker, C., and Kimmel, C.B. (1990) Jaw muscles do not differentiate in a zebrafish mutant that lacks neural crest derived jaw cartilage. The Journal of cell biology. 111:238A
Schilling, T.F., Warga, R.M., and Kimmel, C.B. (1989) Cranial muscles and motoneurons that innervate them originate from the same axial levels in the zebrafish. Soc. Neurosci. Abstr.. 15:810

NON-ZEBRAFISH PUBLICATIONS
1999 Pharyngeal arch patterning in the absence of neural crest.