Schematic illustration of the mosaic introduction of oncogenic cells on zebrafish larval skin Abbreviations: UAS, upstream activation sequence; 2A, 2A self-cleaving peptides; krt4, keratin4.

Schematic illustration of the mechanisms of mosaic Ras mutant cell elimination from zebrafish skin

Schematic illustration of three anti-tumorigenic roles of cellular senescence (A) The induction of irreversible cell cycle arrest in oncogenic cells, (B) The stimulation of immune cell-mediated senescent cell elimination, and (C) Neighboring normal cell-mediated elimination of oncogenic cells.

Schematic illustration of three mechanisms of OIS (A) Oncogenic signaling-induced cellular senescence in a cell-autonomous manner. (B) Senesced oncogenic cells spread senescence to neighboring cells through cell-cell communication. (C) Intercellular communication with neighboring normal cells accelerated senescence in oncogenic signaling-activated cells.

Schematic illustration of the behaviors of Ras mutant and Ras-TP53 double mutant cells and their neighboring cells on healthy and unhealthy epithelia

Schematic illustration of the fate of Ras or Wnt mutant cells and the effects of additional mutations in tumor-suppressor genes and inflammation