PUBLICATION
Zebrafish imaging reveals hidden oncogenic-normal cell communication during primary tumorigenesis
- Authors
- Haraoka, Y., Miyake, M., Ishitani, T.
- ID
- ZDB-PUB-230511-46
- Date
- 2023
- Source
- Cell structure and function 48(1): 113-121 (Journal)
- Registered Authors
- Haraoka, Yukinari, Ishitani, Tohru
- Keywords
- EDAC, cell competition, cell-cell communication, imaging, primary tumorigenesis, senescence, zebrafish
- MeSH Terms
-
- Animals
- Carcinogenesis
- Cell Communication
- Cell Transformation, Neoplastic/pathology
- Humans
- Neoplasms*/pathology
- Zebrafish*/genetics
- PubMed
- 37164759 Full text @ Cell Struct Funct
Citation
Haraoka, Y., Miyake, M., Ishitani, T. (2023) Zebrafish imaging reveals hidden oncogenic-normal cell communication during primary tumorigenesis. Cell structure and function. 48(1):113-121.
Abstract
Oncogenic mutations drive tumorigenesis, and single cells with oncogenic mutations act as the tumor seeds that gradually evolve into fully transformed tumors. However, oncogenic cell behavior and communication with neighboring cells during primary tumorigenesis remain poorly understood. We used the zebrafish, a small vertebrate model suitable for in vivo cell biology, to address these issues. We describe the cooperative and competitive communication between oncogenic cells and neighboring cells, as revealed by our recent zebrafish imaging studies. Newly generated oncogenic cells are actively eliminated by neighboring cells in healthy epithelia, whereas oncogenic cells cooperate with their neighbors to prime tumorigenesis in unhealthy epithelia via additional mutations or inflammation. In addition, we discuss the potential of zebrafish in vivo imaging to determine the initial steps of human tumorigenesis.Key words: zebrafish, imaging, cell-cell communication, cell competition, EDAC, senescence, primary tumorigenesis.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping