Small teleost fish that can be used to model the genomics of sarcopenia. (A) Zebrafish. Image from http://www.fishtankmaintenance.net/zebra-fish-zebrafish-facts/. (B) Medaka. Image from https://aquaticarts.com/collections/killifish/products/pearl-medaka-ricefish. (C) Killifish. Image from https://confessionsofafishgeek.blogspot.com/2013/02/background-nothobranchiusfurzeri-is.html. These images are not published under the terms of the CC-BY license of this article. Please refer to individual sites for further details.

Using model systems to understand and treat sarcopenia. Aging is associated with loss of muscle mass and function, which are highly heritable traits. Combining GWAS with both traditional (rodent and rabbit) and teleost fish (mainly zebrafish) models allows researchers to improve our understanding of the mechanisms of muscle wasting and to search for new therapies. GWAS, genome-wide association studies.