header logo image header logo text
Downloads Login
Research
General Information
ZIRC
ZFIN ID: ZDB-LAB-970425-30
Wullimann Research Group
PI/Director:
Co-PI / Senior
Researcher:
Wullimann, Mario F.
Contact Person: Wullimann, Mario F.
Email: wullimann@zi.biologie.uni-muenchen.de
URL:
Address: Dr. Mario F. Wullimann Ludwig Maximilians-University Department Biologie II - Neurobiologie Abt. Prof. Dr. B. Grothe Grosshadernerstr. 2 D-82152 Planegg-Martinsried Germany
Country: Germany
Phone: 0049 (0)89 2180-74322
Fax: tba
Line Designation: None assigned


GENOMIC FEATURES ORIGINATING FROM THIS LAB No data available


STATEMENT OF RESEARCH INTERESTS
My current research is focused on - but not restricted to - the embryonic/postembryonic development of the teleostean forebrain. Based on our previously established adult neuroanatomy of the zebrafish, we study now developmental aspects (morphogenesis, proliferation, prosomeres, radial glia, neurogenesis, neuronal phenotype development) using various cellular and molecular markers (e.g., early transcription factor expression, markers for neurochemical phenotypes, such as choline acetyltransferase, tyrosine hydroxylase, GABA) in comparison to similar data in the adult zebrafish brain. My background is comparative neurobiology, thus, the ultimate goal of my research is two-fold: (1) our analyses deliver detailed information on the phenotypic level for cross-comparisons between model systems, and (2) at the same time, we aim at furthering the general understanding of the zebrafish (teleost) brain in an evolutionary vertebrate context. Thus, while most of our studies deal with the zebrafish, we also investigate additional teleosts, amphibians (Xenopus), and mouse.


LAB MEMBERS
Mueller, Thomas Rink, Elke


ZEBRAFISH PUBLICATIONS OF LAB MEMBERS x
Baeuml, S.W., Biechl, D., Wullimann, M.F. (2019) Adult islet1 Expression Outlines Ventralized Derivatives Along Zebrafish Neuraxis. Frontiers in Neuroanatomy. 13:19
Biechl, D., Tietje, K., Ryu, S., Grothe, B., Gerlach, G., Wullimann, M.F. (2017) Identification of accessory olfactory system and medial amygdala in the zebrafish. Scientific Reports. 7:44295
Horstick, E.J., Mueller, T., Burgess, H.A. (2016) Motivated state control in larval zebrafish: behavioral paradigms and anatomical substrates. Journal of neurogenetics. 30(2):122-32
Biechl, D., Dorigo, A., Köster, R.W., Grothe, B., Wullimann, M.F. (2016) Eppur Si Muove: Evidence for an External Granular Layer and Possibly Transit Amplification in the Teleostean Cerebellum. Frontiers in Neuroanatomy. 10:49
Biechl, D., Tietje, K., Gerlach, G., Wullimann, M.F. (2016) Crypt cells are involved in kin recognition in larval zebrafish. Scientific Reports. 6:24590
Marquart, G.D., Tabor, K.M., Brown, M., Strykowski, J.L., Varshney, G.K., LaFave, M.C., Mueller, T., Burgess, S.M., Higashijima, S., Burgess, H.A. (2015) A 3D Searchable Database of Transgenic Zebrafish Gal4 and Cre Lines for Functional Neuroanatomy Studies. Frontiers in neural circuits. 9:78
Ishibashi, M., Manning, E., Shoubridge, C., Krecsmarik, M., Hawkins, T.A., Giacomotto, J., Zhao, T., Mueller, T., Bader, P.I., Cheung, S.W., Stankiewicz, P., Bain, N.L., Hackett, A., Reddy, C.C., Mechaly, A.S., Peers, B., Wilson, S.W., Lenhard, B., Bally-Cuif, L., Gecz, J., Becker, T.S., Rinkwitz, S. (2015) Copy number variants in patients with intellectual disability affect the regulation of ARX transcription factor gene. Human genetics. 134(11-12):1163-82
Marquart, G.D., Tabor, K.M., Brown, M., Strykowski, J.L., Varshney, G.K., LaFave, M.C., Mueller, T., Burgess, S.H., Higashijima, S., and Burgess, H.A. (2015) Enhancer Trap Transgenics. ZFIN Direct Data Submission.
Filippi, A., Mueller, T., and Driever, W. (2014) Vglut2 and gad expression reveal distinct patterns of dual GABAergic versus glutamatergic cotransmitter phenotypes of dopaminergic and noradrenergic neurons in the zebrafish brain. The Journal of comparative neurology. 522(9):2019-37
Herget, U., Wolf, A., Wullimann, M.F., and Ryu, S. (2014) Molecular neuroanatomy and chemoarchitecture of the neurosecretory preoptic-hypothalamic area in zebrafish larvae. The Journal of comparative neurology. 522(7):1542-64
Wullimann M.F. (2013) Ancestry of basal ganglia circuits: new evidence in teleosts. The Journal of comparative neurology. 522(9):2013-2018
Haug, M.F., Gesemann, M., Mueller, T., and Neuhauss, S.C. (2013) Phylogeny and expression divergence of metabotropic glutamate receptor genes in the brain of zebrafish (Danio rerio). The Journal of comparative neurology. 521(7):1533-1560
Kress, S., and Wullimann, M.F. (2012) Correlated basal expression of immediate early gene egr1 and tyrosine hydroxylase in zebrafish brain and downregulation in olfactory bulb after transitory olfactory deprivation. Journal of chemical neuroanatomy. 46(1-2):51-66
Ronneberger, O., Liu, K., Rath, M., Rueβ, D., Mueller, T., Skibbe, H., Drayer, B., Schmidt, T., Filippi, A., Nitschke, R., Brox, T., Burkhardt, H., Driever, W. (2012) ViBE-Z: a framework for 3D virtual colocalization analysis in zebrafish larval brains. Nature Methods. 9(7):735-742
Mueller, T. (2012) What is the Thalamus in Zebrafish?. Frontiers in Neurogenesis. 6:64
Wullimann, M.F., Mueller, T., Distel, M., Babaryka, A., Grothe, B., and Köster, R.W. (2011) The long adventurous journey of rhombic lip cells in jawed vertebrates: a comparative developmental analysis. Frontiers in Neuroanatomy. 5:27
Mueller, T., Dong, Z., Berberoglu, M.A., and Guo, S. (2011) The dorsal pallium in Zebrafish, Danio rerio (Cyprinidae, Teleostei). Brain research. 1381:95-105
Yamamoto, K., Ruuskanen, J.O., Wullimann, M.F., and Vernier, P. (2011) Differential expression of dopaminergic cell markers in the adult zebrafish forebrain. The Journal of comparative neurology. 519(3):576-598
Volkmann, K., Chen, Y.Y., Harris, M.P., Wullimann, M.F., and Köster, R.W. (2010) The zebrafish cerebellar upper rhombic lip generates tegmental hindbrain nuclei by long-distance migration in an evolutionary conserved manner. The Journal of comparative neurology. 518(14):2794-2817
Yamamoto, K., Ruuskanen, J.O., Wullimann, M.F., and Vernier, P. (2010) Two tyrosine hydroxylase genes in vertebrates: New dopaminergic territories revealed in the zebrafish brain. Molecular and cellular neurosciences. 43(4):394-402
Osório, J., Mueller, T., Rétaux, S., Vernier, P., and Wullimann, M.F. (2010) Phylotypic expression of the bHLH genes Neurogenin2, Neurod, and Mash1 in the mouse embryonic forebrain. The Journal of comparative neurology. 518(6):851-871
Mueller, T., and Guo, S. (2009) The distribution of GAD67-mRNA in the adult zebrafish (teleost) forebrain reveals a prosomeric pattern and suggests previously unidentified homologies to tetrapods. The Journal of comparative neurology. 516(6):553-568
Berberoglu, M.A., Dong, Z., Mueller, T., and Guo, S. (2009) fezf2 expression delineates cells with proliferative potential and expressing markers of neural stem cells in the adult zebrafish brain. Gene expression patterns : GEP. 9(6):411-422
Distel, M., Wullimann, M.F., and Köster, R.W. (2009) Optimized Gal4 genetics for permanent gene expression mapping in zebrafish. Proceedings of the National Academy of Sciences of the United States of America. 106(32):13365-13370
Peng, J., Wagle, M., Mueller, T., Mathur, P., Lockwood, B.L., Bretaud, S., and Guo, S. (2009) Ethanol-modulated camouflage response screen in zebrafish uncovers a novel role for cAMP and extracellular signal-regulated kinase signaling in behavioral sensitivity to ethanol. The Journal of neuroscience : the official journal of the Society for Neuroscience. 29(26):8408-8418
Wullimann, M.F. (2009) Secondary neurogenesis and telencephalic organization in zebrafish and mice: a brief review. Integrative Zoology. 4(1):123-133
Lillesaar, C., Stigloher, C., Tannhäuser, B., Wullimann, M.F., and Bally-Cuif, L. (2009) Axonal projections originating from raphe serotonergic neurons in the developing and adult zebrafish, Danio rerio, using transgenics to visualize raphe-specific pet1 expression. The Journal of comparative neurology. 512(2):158-182
Mueller, T., and Wullimann, M.F. (2009) An evolutionary interpretation of teleostean forebrain anatomy. Brain, behavior and evolution. 74(1):30-42
Mueller, T., Wullimann, M.F., and Guo, S. (2008) Early teleostean basal ganglia development visualized by Zebrafish Dlx2a, Lhx6, Lhx7, Tbr2 (eomesa), and GAD67 gene expression. The Journal of comparative neurology. 507(2):1245-1257
Sive, H., Mueller, T., Wullimann, M.F., Kuwada, J.Y., Moorman, S.J., Haendel, M.A. (2006) ZFIN Anatomy Working Group: Nervous System. Manually curated data.
Mueller, T., Vernier, P., and Wullimann, M.F. (2006) A phylotypic stage in vertebrate brain development: GABA cell patterns in zebrafish compared with mouse. The Journal of comparative neurology. 494(4):620-634
Wullimann, M.F., Rink, E., Vernier, P., and Schlosser, G. (2005) Secondary neurogenesis in the brain of the African clawed frog, Xenopus laevis, as revealed by PCNA, Delta-1, Neurogenin-related-1, and NeuroD expression. The Journal of comparative neurology. 489(3):387-402
Mueller, T., and Wullimann, M.F. (2005) Atlas of Early Zebrafish Brain Development: A Tool for Molecular Neurogenetics. Elsevier Science. :183p
Wullimann, M.F., and Mueller, T. (2004) Teleostean and mammalian forebrains contrasted: Evidence from genes to behavior. The Journal of comparative neurology. 475(2):143-162
Mueller, T., Vernier, P., and Wullimann, M.F. (2004) The adult central nervous cholinergic system of a neurogenetic model animal, the zebrafish Danio rerio. Brain research. 1011(2):156-169
Rink, E., and Wullimann, M.F. (2004) Connections of the ventral telencephalon (subpallium) in the zebrafish (Danio rerio). Brain research. 1011(2):206-220
Wullimann, M.F., and Mueller, T. (2004) Identification and morphogenesis of the eminentia thalami in the zebrafish. The Journal of comparative neurology. 471(1):37-48
Rink, E., and Guo, S. (2004) The too few mutant selectively affects subgroups of monoaminergic neurons in the zebrafish forebrain. Neuroscience. 127(1):147-154
Mueller, T., and Wullimann, M.F. (2003) Anatomy of neurogenesis in the early zebrafish brain. Brain research. Developmental brain research. 140(1):137-155
Bellipanni, G., Rink, E., and Bally-Cuif, L. (2002) Cloning of two tryptophan hydroxylase genes expressed in the diencephalon of the developing zebrafish brain. Mechanisms of Development. 119:S215-S220
Bellipanni, G., Rink, E., and Bally-Cuif, L. (2002) RETRACTED: Cloning of two tryptophan hydroxylase genes expressed in the diencephalon of the developing zebrafish brain. Gene expression patterns : GEP. 2(3-4):251-256
Wullimann, M.F., and Mueller, T. (2002) Expression of Zash-1a in the postembryonic zebrafish brain allows comparison to mouse Mash1 domains. Gene expression patterns : GEP. 1(3-4):187-192
Mueller, T., and Wullimann, M. (2002) BrdU-, neuroD (nrd)- and Hu-studies reveal unusual non-ventricular neurogenesis in the postembryonic zebrafish forebrain. Mechanisms of Development. 117(1-2):123-135
Rink, E. and Wullimann, M.F. (2002) Development of the catecholaminergic system in the early zebrafish brain: an immunohistochemical study. Brain research. Developmental brain research. 137(1):89-100
Mueller, T., and Wullimann, M.F. (2002) Expression domains of neuroD (nrd) in the early postembryonic zebrafish brain. Brain research bulletin. 57(3-4):377-379
Rink, E. and Wullimann, M.F. (2002) Connections of the ventral telencephalon and tyrosine hydroxylase distribution in the zebrafish brain (Danio rerio) lead to identification of an ascending dopaminergic system in a teleost. Brain research bulletin. 57(3-4):385-387
Wullimann, M.F. and Rink, E. (2002) The teleostean forebrain: a comparative and developmental view based on early proliferation, Pax6 activity and catecholaminergic organization. Brain research bulletin. 57(3-4):363-370
Wullimann, M.F. and Rink, E. (2001) Detailed immunohistology of Pax6 protein and tyrosine hydroxylase in the early zebrafish brain suggests role of Pax6 gene in development of dopaminergic diencephalic neurons. Brain research. Developmental brain research. 131(1-2):173-191
Rink, E. and Wullimann, M.F. (2001) The teleostean (zebrafish) dopaminergic system ascending to the subpallium (striatum) is located in the basal diencephalon (posterior tuberculum). Brain research. 889:316-330
Wullimann, M.F. (2001) Brain phenotypes and early regulatory genes: the bauplanof the metazoan central nervous system. In Brain Evolution and Cognition, G. Roth and M.F. Wullimann, eds., New York and Heidelberg: Spektrum Akademischer Verlag and J. Wiley & Sons. :11-39
Wullimann, M.F. and Knipp, S. (2000) Proliferation pattern changes in the zebrafish brain from embryonic through early postembryonic stages. Anatomy and embryology. 202:385-400
Wullimann M.F. and Puelles, L. (1999) Postembryonic neural proliferation in the zebrafish forebrain and its relationship to prosomeric domains. Anatomy and embryology. 199:329-348
Wullimann M.F., Puelles, L., and Wicht, H. (1999) Early postembryonic neural development in the zebrafish: a 3-D reconstruction of forebrain proliferation zones shows their relationship to prosomeres. Eur. J. Morphol.. 37:117-121
Becker, T., R.R. Bernhardt, E. Reinhard, M.F. Wullimann, E. Tongiorgi, and M. Schachner (1998) Readiness of zebrafish brain neurons to regenerate a spinal axon correlates with differential expression of specific cell recognition molecules. The Journal of neuroscience : the official journal of the Society for Neuroscience. 18:5789-5803
Becker, T., Wullimann, M.F., Becker, C.G., Bernhardt, R.R., and Schachner, M. (1997) Axonal regrowth after spinal cord transection in adult zebrafish. The Journal of comparative neurology. 377(4):577-595
Wullimann M.F. (1997) The central nervous system. In Physiology of Fishes, Vol. II, Evans D.H., ed, Boca Raton: CRC Press. :245-282
Rupp, B., Wullimann, M.F., and Reichert, H. (1996) The zebrafish brain: a neuroanatomical comparison with the goldfish. Anatomy and embryology. 194:187-203
Wullimann, M.F., Rupp, B., Reichert, H., and eds. (1996) Neuroanatomy of the Zebrafish Brain. A Topological Atlas. Basel, Switzerland: Basel, Switzerland: Birkhäuser Verlag. :160 p