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ZIRC
ZFIN ID: ZDB-PERS-970124-7
Wullimann, Mario F.
Email: wullimann@bio.lmu.de
URL:
Affiliation: Wullimann Research Group
Address: Dr. Mario F. Wullimann Ludwig Maximilians-University Department Biologie II - Neurobiologie Abt. Prof. Dr. B. Grothe Grosshadernerstr. 2 Planegg-Martinsried, D-82152 Germany
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Phone: 0049 (0)89-218074322
Fax: tba
Orcid ID:


BIOGRAPHY AND RESEARCH INTERESTS
My current research is focused on - but not restricted to - the embryonic/postembryonic development of the teleostean forebrain. Based on our previously established adult neuroanatomy of the zebrafish, we study now developmental aspects (morphogenesis, proliferation, prosomeres, radial glia, neurogenesis, neuronal phenotype development) using various cellular and molecular markers (e.g., early transcription factor expression, markers for neurochemical phenotypes, such as choline acetyltransferase, tyrosine hydroxylase, GABA) in comparison to similar data in the adult zebrafish brain. My background is comparative neurobiology, thus, the ultimate goal of my research is two-fold: (1) our analyses deliver detailed information on the phenotypic level for cross-comparisons between model systems, and (2) at the same time, we aim at furthering the general understanding of the zebrafish (teleost) brain in an evolutionary vertebrate context. Thus, while most of our studies deal with the zebrafish, we also investigate additional teleosts, amphibians (Xenopus), and mouse.


PUBLICATIONS
Baeuml, S.W., Biechl, D., Wullimann, M.F. (2019) Adult islet1 Expression Outlines Ventralized Derivatives Along Zebrafish Neuraxis. Frontiers in Neuroanatomy. 13:19
Biechl, D., Tietje, K., Ryu, S., Grothe, B., Gerlach, G., Wullimann, M.F. (2017) Identification of accessory olfactory system and medial amygdala in the zebrafish. Scientific Reports. 7:44295
Biechl, D., Dorigo, A., Köster, R.W., Grothe, B., Wullimann, M.F. (2016) Eppur Si Muove: Evidence for an External Granular Layer and Possibly Transit Amplification in the Teleostean Cerebellum. Frontiers in Neuroanatomy. 10:49
Biechl, D., Tietje, K., Gerlach, G., Wullimann, M.F. (2016) Crypt cells are involved in kin recognition in larval zebrafish. Scientific Reports. 6:24590
Herget, U., Wolf, A., Wullimann, M.F., and Ryu, S. (2014) Molecular neuroanatomy and chemoarchitecture of the neurosecretory preoptic-hypothalamic area in zebrafish larvae. The Journal of comparative neurology. 522(7):1542-64
Wullimann M.F. (2013) Ancestry of basal ganglia circuits: new evidence in teleosts. The Journal of comparative neurology. 522(9):2013-2018
Kress, S., and Wullimann, M.F. (2012) Correlated basal expression of immediate early gene egr1 and tyrosine hydroxylase in zebrafish brain and downregulation in olfactory bulb after transitory olfactory deprivation. Journal of chemical neuroanatomy. 46(1-2):51-66
Wullimann, M.F., Mueller, T., Distel, M., Babaryka, A., Grothe, B., and Köster, R.W. (2011) The long adventurous journey of rhombic lip cells in jawed vertebrates: a comparative developmental analysis. Frontiers in Neuroanatomy. 5:27
Yamamoto, K., Ruuskanen, J.O., Wullimann, M.F., and Vernier, P. (2011) Differential expression of dopaminergic cell markers in the adult zebrafish forebrain. The Journal of comparative neurology. 519(3):576-598
Volkmann, K., Chen, Y.Y., Harris, M.P., Wullimann, M.F., and Köster, R.W. (2010) The zebrafish cerebellar upper rhombic lip generates tegmental hindbrain nuclei by long-distance migration in an evolutionary conserved manner. The Journal of comparative neurology. 518(14):2794-2817
Yamamoto, K., Ruuskanen, J.O., Wullimann, M.F., and Vernier, P. (2010) Two tyrosine hydroxylase genes in vertebrates: New dopaminergic territories revealed in the zebrafish brain. Molecular and cellular neurosciences. 43(4):394-402
Osório, J., Mueller, T., Rétaux, S., Vernier, P., and Wullimann, M.F. (2010) Phylotypic expression of the bHLH genes Neurogenin2, Neurod, and Mash1 in the mouse embryonic forebrain. The Journal of comparative neurology. 518(6):851-871
Distel, M., Wullimann, M.F., and Köster, R.W. (2009) Optimized Gal4 genetics for permanent gene expression mapping in zebrafish. Proceedings of the National Academy of Sciences of the United States of America. 106(32):13365-13370
Wullimann, M.F. (2009) Secondary neurogenesis and telencephalic organization in zebrafish and mice: a brief review. Integrative Zoology. 4(1):123-133
Lillesaar, C., Stigloher, C., Tannhäuser, B., Wullimann, M.F., and Bally-Cuif, L. (2009) Axonal projections originating from raphe serotonergic neurons in the developing and adult zebrafish, Danio rerio, using transgenics to visualize raphe-specific pet1 expression. The Journal of comparative neurology. 512(2):158-182
Mueller, T., and Wullimann, M.F. (2009) An evolutionary interpretation of teleostean forebrain anatomy. Brain, behavior and evolution. 74(1):30-42
Mueller, T., Wullimann, M.F., and Guo, S. (2008) Early teleostean basal ganglia development visualized by Zebrafish Dlx2a, Lhx6, Lhx7, Tbr2 (eomesa), and GAD67 gene expression. The Journal of comparative neurology. 507(2):1245-1257
Sive, H., Mueller, T., Wullimann, M.F., Kuwada, J.Y., Moorman, S.J., Haendel, M.A. (2006) ZFIN Anatomy Working Group: Nervous System. Manually curated data.
Mueller, T., Vernier, P., and Wullimann, M.F. (2006) A phylotypic stage in vertebrate brain development: GABA cell patterns in zebrafish compared with mouse. The Journal of comparative neurology. 494(4):620-634
Wullimann, M.F., Rink, E., Vernier, P., and Schlosser, G. (2005) Secondary neurogenesis in the brain of the African clawed frog, Xenopus laevis, as revealed by PCNA, Delta-1, Neurogenin-related-1, and NeuroD expression. The Journal of comparative neurology. 489(3):387-402
Mueller, T., and Wullimann, M.F. (2005) Atlas of Early Zebrafish Brain Development: A Tool for Molecular Neurogenetics. Elsevier Science. :183p
Wullimann, M.F., and Mueller, T. (2004) Teleostean and mammalian forebrains contrasted: Evidence from genes to behavior. The Journal of comparative neurology. 475(2):143-162
Mueller, T., Vernier, P., and Wullimann, M.F. (2004) The adult central nervous cholinergic system of a neurogenetic model animal, the zebrafish Danio rerio. Brain research. 1011(2):156-169
Rink, E., and Wullimann, M.F. (2004) Connections of the ventral telencephalon (subpallium) in the zebrafish (Danio rerio). Brain research. 1011(2):206-220
Wullimann, M.F., and Mueller, T. (2004) Identification and morphogenesis of the eminentia thalami in the zebrafish. The Journal of comparative neurology. 471(1):37-48
Mueller, T., and Wullimann, M.F. (2003) Anatomy of neurogenesis in the early zebrafish brain. Brain research. Developmental brain research. 140(1):137-155
Wullimann, M.F., and Mueller, T. (2002) Expression of Zash-1a in the postembryonic zebrafish brain allows comparison to mouse Mash1 domains. Gene expression patterns : GEP. 1(3-4):187-192
Mueller, T., and Wullimann, M. (2002) BrdU-, neuroD (nrd)- and Hu-studies reveal unusual non-ventricular neurogenesis in the postembryonic zebrafish forebrain. Mechanisms of Development. 117(1-2):123-135
Rink, E. and Wullimann, M.F. (2002) Development of the catecholaminergic system in the early zebrafish brain: an immunohistochemical study. Brain research. Developmental brain research. 137(1):89-100
Wullimann, M.F. and Rink, E. (2002) The teleostean forebrain: a comparative and developmental view based on early proliferation, Pax6 activity and catecholaminergic organization. Brain research bulletin. 57(3-4):363-370
Rink, E. and Wullimann, M.F. (2002) Connections of the ventral telencephalon and tyrosine hydroxylase distribution in the zebrafish brain (Danio rerio) lead to identification of an ascending dopaminergic system in a teleost. Brain research bulletin. 57(3-4):385-387
Mueller, T., and Wullimann, M.F. (2002) Expression domains of neuroD (nrd) in the early postembryonic zebrafish brain. Brain research bulletin. 57(3-4):377-379
Wullimann, M.F. and Rink, E. (2001) Detailed immunohistology of Pax6 protein and tyrosine hydroxylase in the early zebrafish brain suggests role of Pax6 gene in development of dopaminergic diencephalic neurons. Brain research. Developmental brain research. 131(1-2):173-191
Rink, E. and Wullimann, M.F. (2001) The teleostean (zebrafish) dopaminergic system ascending to the subpallium (striatum) is located in the basal diencephalon (posterior tuberculum). Brain research. 889:316-330
Wullimann, M.F. (2001) Brain phenotypes and early regulatory genes: the bauplanof the metazoan central nervous system. In Brain Evolution and Cognition, G. Roth and M.F. Wullimann, eds., New York and Heidelberg: Spektrum Akademischer Verlag and J. Wiley & Sons. :11-39
Wullimann, M.F. and Knipp, S. (2000) Proliferation pattern changes in the zebrafish brain from embryonic through early postembryonic stages. Anatomy and embryology. 202:385-400
Wullimann M.F., Puelles, L., and Wicht, H. (1999) Early postembryonic neural development in the zebrafish: a 3-D reconstruction of forebrain proliferation zones shows their relationship to prosomeres. Eur. J. Morphol.. 37:117-121
Wullimann M.F. and Puelles, L. (1999) Postembryonic neural proliferation in the zebrafish forebrain and its relationship to prosomeric domains. Anatomy and embryology. 199:329-348
Becker, T., R.R. Bernhardt, E. Reinhard, M.F. Wullimann, E. Tongiorgi, and M. Schachner (1998) Readiness of zebrafish brain neurons to regenerate a spinal axon correlates with differential expression of specific cell recognition molecules. The Journal of neuroscience : the official journal of the Society for Neuroscience. 18:5789-5803
Becker, T., Wullimann, M.F., Becker, C.G., Bernhardt, R.R., and Schachner, M. (1997) Axonal regrowth after spinal cord transection in adult zebrafish. The Journal of comparative neurology. 377(4):577-595
Wullimann M.F. (1997) The central nervous system. In Physiology of Fishes, Vol. II, Evans D.H., ed, Boca Raton: CRC Press. :245-282
Rupp, B., Wullimann, M.F., and Reichert, H. (1996) The zebrafish brain: a neuroanatomical comparison with the goldfish. Anatomy and embryology. 194:187-203
Wullimann, M.F., Rupp, B., Reichert, H., and eds. (1996) Neuroanatomy of the Zebrafish Brain. A Topological Atlas. Basel, Switzerland: Basel, Switzerland: Birkhäuser Verlag. :160 p

NON-ZEBRAFISH PUBLICATIONS
Zeymer M; von der Emde; Wullimann MF (2018)
The mormyrid optic tectum is a topographic interface for active electrolocation and visual sensing
Front Neuroanat 12:79. doi.org/10.3389/fnana.2018.00079.

Wullimann MF (2017)
Should we redefine the lateral pallium?
J Comp Neurol 525: 1509-1513. doi: 10.1002/cne.24127. Epub 2016 Nov 3.


Karoubi N; Segev R; Wullimann MF (2016)
The brain of the archerfish Toxotes chatareus: A Nissl-based neuroanatomical atlas and catecholaminergic/cholinergic systems
Front Neuroanat 10, Article 106. doi: 10.3389/fnana.2016.00106.

Book Articles:
Wullimann MF (2016)
Nervous system architecture in vertebrates
In: Handbook of Evolutionary Neuroscience, Shepherd SV (ed), Oxford, Wiley-Blackwell. pp 236-278.

Wullimann MF (2014)
Zentrales Nervensystem (ZNS)
In: Spezielle Zoologie, Teil 2: Wirbel- oder Schädeltiere, pp. 70-80, 3. Auflage, Westheide W. & Rieger G. (Hrsg), Heidelberg, Springer

Wullimann MF; Grothe B (2013)
The central nervous organization of the lateral line system
In: The lateral line system, Springer Handbook of Auditory Research, 2014, Vol. 48: pp. 195-251, Popper A, Fay R, Coombs S, Bleckmann H (eds). Heidelberg-New York, Springer DOI 10.1007/2506 (eBook 2013 Aug 6)

Wullimann MF (2011) Basal ganglia: insights into origins from lamprey brains
Curr Biol 21: R497-500

Wullimann, M. and Vernier, P. (2006) Evolution of the Nervous System in Fishes. In Evolution of Nervous Systems, (J. Kaas, ed.) Elsevier, 5 Volumes.

Wullimann M. & D.G. Senn: Zur Morphologie der Lateralis-Innervation bei Mormyriden- Fischen (Brienomyrus spec. Taverne 1971, Mormyridae, Teleostei). Verhandl. Naturf. Ges. Basel 92: 63-72 (1981)

Wullimann M., W. Finck & D.G. Senn: A hypothalamic channel-system in the inferior lobes of a trigger-fish (Rhinecanthus aculeatus, Balistidae). Experientia 40: 725-727 (1984)

Wullimann M.F.: The hypothalamic, ventricular channel-system and its phylogenetic distribution among fishes. In: S.O. Kullander & B. Fernholm (eds), Proc. V. Int. Congr.Europ. Ichthyol.(Stockholm, 1985), pp. 65-72 (1987)

Wullimann M.F.: The tertiary gustatory center in sunfishes is not nucleus glomerulosus. Neurosci. Letters 86: 6-10 (1988)

Wullimann M.F. & R.G. Northcutt: Connections of the corpus cerebelli in the green sunfish and the common goldfish: A comparison of perciform and cypriniform teleosts. Brain Behav. Evol.32: 293-316 (1988)

Wathey J.C. & M.F. Wullimann: A double-label study of efferent projections from the Edinger- Westphal nucleus in goldfish and kelp bass. Neurosci. Letters 93: 121-126 (1988)

Northcutt R.G. & M.F. Wullimann: The visual system in teleost fishes: morphological patterns and trends. In: J. Atema, R.R. Fay, A.N. Popper & W.N. Tavolga (eds), Sensory Biology of Aquatic Animals, pp. 515-552, Springer, New York (1988)

Wullimann M.F. & R.G. Northcutt: Afferent connections of the valvula cerebelli in two teleosts, the common goldfish and the green sunfish.
J. Comp. Neurol. 289: 554-567 (1989)

Wullimann M.F. & R.G. Northcutt: Visual and electrosensory circuits of the diencephalon in mormyrids: an evolutionary perspective.
J. Comp. Neurol. 297: 537-552 (1990)

Wullimann M.F. & D.J. Rooney: A direct cerebello-telencephalic projection in an electrosensory mormyrid fish. Brain Research 520: 354-357 (1990)

Wullimann M.F. & D.L. Meyer: Phylogeny of putative cholinergic visual pathways through the pretectum to the hypothalamus in teleost fish.
Brain Behav. Evol. 36: 14-29 (1990)

Butler A.B., M.F. Wullimann & R.G. Northcutt: Comparative cytoarchitectonic analysis of some visual pretectal nuclei in teleosts. Brain Behav. Evol. 38: 92-114 (1991)

Wullimann M.F., D.L. Meyer & R.G. Northcutt: The visually related posterior pretectal nucleus in the non-percomorph teleost Osteoglossum bicirrhosum projects to the hypothalamus: A DiI study.
J. Comp. Neurol. 312: 415-435 (1991)

Wullimann M.F., M.H. Hofmann & D.L. Meyer: Histochemical, connectional and cytoarchitectonic evidence for a secondary reduction of the pretectum in the European eel, Anguilla anguilla: A case of parallel evolution. Brain Behav. Evol. 38: 290-301 (1991)

Wullimann M.F., M.H. Hofmann & D.L. Meyer: The valvula cerebelli of the spiny eel, Macrognathus aculeatus, receives primary lateral-line afferents from the rostrum of the upper jaw. Cell Tissue Research 266: 285-293 (1991)

Wullimann M.F. & G. Roth: Is the nucleus corticalis of teleosts a new cholinergic central nervous system for vertebrates? NeuroReport 3: 33-35 (1992)

Wullimann M.F. & D.L. Meyer: Possible multiple evolution of telencephalo-cerebellar systems in teleosts: Studies in Carassius auratus and Pantodon buchholzi. Cell Tissue Research 274: 447-455 (1993)

Wullimann M.F. & G. Roth: Descending telencephalic information reaches longitudinal torus and cerebellum via the dorsal preglomerular nucleus in the teleost fish, Pantodon buchholzi: A case of neural preaptation? Brain Behav. Evol. 44: 338-352 (1994)

Wullimann M.F.: The teleostean torus longitudinalis: A short review on its structure, histochemistry, connectivity, possible function and phylogeny. Europ. J. Morphol. 32: 235-242 (1994)

Roth G. & M.F. Wullimann: Evolution der Nervensysteme und der Sinnesorgane. In: J. Dudel, R. Menzel, R.F. Schmidt (Hrs.), Neurowissenschaft: Vom Molekül zur Kognition, pp. 1-31, Springer, Heidelberg (1996)

Wullimann M.F.: The central nervous system. In: Evans D.H. (ed), Physiology of Fishes, pp. 245-282, Vol. II, CRC Press, Boca Raton (1997)

Wullimann M.F.: Die Evolution des Wirbeltiergehirns: Gehirnbauplan, Phylogenetische Methode und fr ühe Entwicklungsgene. In: V. K önig & H. Hohmann (Hrsg.): Bausteine der Evolution (Symposium Übersee- Museum Bremen 1995), pp. 85-104, Edition Archaea, Schwelm (1997)

Wullimann M.F.: Major patterns of visual brain organization in teleosts and their relation to prehistoric events and the paleontological record. Paleobiology 23: 101-114 (1997)

Rink E. & M.F. Wullimann: Some forebrain connections of the gustatory system in the goldfish Carassius auratus visualized by separate DiI application to the hypothalamic inferior lobe and the torus lateralis. J. Comp. Neurol. 394: 152-170 (1998)

Wullimann M.F.: Brain phenotypes and early regulatory genes: the bauplan of the metazoan central nervous system. In: Roth G. & M.F. Wullimann (eds): Brain evolution and cognition, pp. 11-39, J. Wiley & Sons and Spektrum Akademischer Verlag, New York and Heidelberg (2000)

Wullimann M.F. & G. Roth: Problems in the study of brain evolution and cognition. In: Roth G. & M.F. Wullimann (eds): Brain evolution and cognition, pp. 1-7,J. Wiley & Sons and Spektrum Akademischer Verlag, New York and Heidelberg (2000)

Roth G. & M.F. Wullimann: Evolution der Nervensysteme und der Sinnesorgane. In: J. Dudel, R. Menzel, R.F. Schmidt (Hrs.), Neurowissenschaft: Vom Molekül zur Kognition, pp. 1-31, Springer, Heidelberg (2000, revised 2nd edition)

Wullimann MF, Rink E, Vernier P, Schlosser G (2005)
Secondary neurogenesis in the brain of the African clawed frog, Xenopus laevis, as revealed by PCNA, Delta-1, Neurogenin-related-1, and NeuroD expression
J Comp Neurol 489(3): 387-402

Book articles

Vernier P, Wullimann MF (2009)
The posterior tuberculum
In: Encyclopedia of Neuroscience, 1404-1413, Binder M.D., Hirokawa N., and Windhorst U. (Hrsg.), Heidelberg, Springer

Wullimann MF, Vernier P (2009)
Evolution of the brain in fishes
In: Encyclopedia of Neuroscience, 2: 1318-1326, Binder M.D., Hirokawa N., and Windhorst U. (eds), Heidelberg, Springer

Wullimann MF, Vernier P (2009)
Evolution of the telencephalon in anamniotes
In: Encyclopedia of Neuroscience, Vol 2: pp. 1424-1431, Binder M.D., Hirokawa N. & Windhorst U. (Editors-in-Chief) Heidelberg, Springer

Wullimann MF (2009)
Zentrales Nervensystem (ZNS)
In: Spezielle Zoologie, Teil 2: Wirbel- oder Schädeltiere, pp. 77-88, Westheide W. & Rieger G. (Hrsg), Heidelberg, Springer.