ZFIN ID: ZDB-LAB-180228-2
Mechanics of neuronal development
PI/Director: Breau, Marie
Contact Person: Breau, Marie
Email: marie.breau@upmc.fr
URL: http://www.ibps.upmc.fr/en/research/developmental-biology-laboratory/mechanics-neuronal-development
Address: Institut de Biologie Paris Seine Laboratoire de Biologie du Développement / Laboratoire Jean Perrin 9 Quai Saint-Bernard, Bât C 7ème étage, case 24 75252 Paris Cedex 05
Country: France
Phone: +331 44 27 21 55
Line Designation: None assigned


While the chemical guidance cues involved in neuronal circuit formation are extensively studied, the influence of mechanical signals remains largely unexplored. In the lab we address this novel question using the zebrafish olfactory circuit as a model system.

Baraban, Marion Post-Doc Gangatharan, Girisaran Post-Doc Monnot, Pauline Graduate Student

Baraban, M., Gordillo Pi, C., Bonnet, I., Gilles, J.F., Lejeune, C., Cabrera, M., Tep, F., Breau, M.A. (2023) Actomyosin contractility in olfactory placode neurons opens the skin epithelium to form the zebrafish nostril. Developmental Cell. 58(5):361-375.e5
Monnot, P., Gangatharan, G., Baraban, M., Pottin, K., Cabrera, M., Bonnet, I., Breau, M.A. (2021) Intertissue mechanical interactions shape the olfactory circuit in zebrafish. EMBO reports. 23(2):e52963
Baraban, M., Koudelka, S., Lyons, D.A. (2018) Ca 2+ activity signatures of myelin sheath formation and growth in vivo. Nature Neuroscience. 21:19-23
Breau, M.A., Bonnet, I., Stoufflet, J., Xie, J., De Castro, S., Schneider-Maunoury, S. (2017) Extrinsic mechanical forces mediate retrograde axon extension in a developing neuronal circuit. Nature communications. 8:282
Koudelka, S., Voas, M.G., Almeida, R.G., Baraban, M., Soetaert, J., Meyer, M.P., Talbot, W.S., Lyons, D.A. (2016) Individual Neuronal Subtypes Exhibit Diversity in CNS Myelination Mediated by Synaptic Vesicle Release. Current biology : CB. 26(11):1447-55
Mensch, S., Baraban, M., Almeida, R., Czopka, T., Ausborn, J., El Manira, A., Lyons, D. A. (2015) Synaptic vesicle release regulates myelin sheath number of individual oligodendrocytes in vivo. Nature Neuroscience. 18:628-630
Breau, M.A., Wilkinson, D.G., and Xu, Q. (2013) A Hox gene controls lateral line cell migration by regulating chemokine receptor expression downstream of Wnt signaling. Proceedings of the National Academy of Sciences of the United States of America. 110(42):16892-16897
Baraban, M., Anselme, I., Schneider-Maunoury, S., and Giudicelli, F. (2013) Zebrafish embryonic neurons transport messenger RNA to axons and growth cones in vivo. The Journal of neuroscience : the official journal of the Society for Neuroscience. 33(40):15726-15734
Gerety, S.S., Breau, M.A., Sasai, N., Xu, Q., Briscoe, J., and Wilkinson, D.G. (2013) An inducible transgene expression system for zebrafish and chick. Development (Cambridge, England). 140(10):2235-2243
Breau, M.A., Wilson, D., Wilkinson, D.G., and Xu, Q. (2012) Chemokine and Fgf signalling act as opposing guidance cues in formation of the lateral line primordium. Development (Cambridge, England). 139(12):2246-2253