ZFIN ID: ZDB-PUB-190510-19
Ca 2+ activity signatures of myelin sheath formation and growth in vivo
Baraban, M., Koudelka, S., Lyons, D.A.
Date: 2018
Source: Nature Neuroscience   21: 19-23 (Other)
Registered Authors: Baraban, Marion, Lyons, David A.
Keywords: none
MeSH Terms:
  • Acrylates/pharmacology
  • Animals
  • Animals, Genetically Modified
  • Axons/physiology*
  • Calcium/metabolism*
  • Calpain/antagonists & inhibitors
  • Larva
  • Luminescent Proteins/genetics
  • Luminescent Proteins/metabolism
  • Myelin Sheath/drug effects
  • Myelin Sheath/metabolism*
  • Oligodendroglia/drug effects
  • Oligodendroglia/physiology*
  • RNA, Messenger/metabolism
  • SOXE Transcription Factors/genetics
  • SOXE Transcription Factors/metabolism
  • Spinal Cord/physiology*
  • Time Factors
  • Time-Lapse Imaging
  • Zebrafish
  • Zebrafish Proteins/genetics
  • Zebrafish Proteins/metabolism
PubMed: 29230058 Full text @ Nat. Neurosci.
FIGURES
ABSTRACT
During myelination, individual oligodendrocytes initially over-produce short myelin sheaths, which are either retracted or stabilized. By live-imaging oligodendrocyte Ca2+ activity in vivo, we find that high-amplitude, long-duration Ca2+ transients in sheaths prefigure retractions, mediated by calpain. Following stabilization, myelin sheaths grow along axons, and we find that higher-frequency Ca2+ transient activity in sheaths precedes faster elongation. Our data implicate local Ca2+ signaling in regulating distinct stages of myelination.
ADDITIONAL INFORMATION No data available