|ZFIN ID: ZDB-PUB-190510-19|
Ca 2+ activity signatures of myelin sheath formation and growth in vivo
Baraban, M., Koudelka, S., Lyons, D.A.
|Source:||Nature Neuroscience 21: 19-23 (Other)|
|Registered Authors:||Baraban, Marion, Lyons, David A.|
|PubMed:||29230058 Full text @ Nat. Neurosci.|
Baraban, M., Koudelka, S., Lyons, D.A. (2018) Ca 2+ activity signatures of myelin sheath formation and growth in vivo. Nature Neuroscience. 21:19-23.
ABSTRACTDuring myelination, individual oligodendrocytes initially over-produce short myelin sheaths, which are either retracted or stabilized. By live-imaging oligodendrocyte Ca2+ activity in vivo, we find that high-amplitude, long-duration Ca2+ transients in sheaths prefigure retractions, mediated by calpain. Following stabilization, myelin sheaths grow along axons, and we find that higher-frequency Ca2+ transient activity in sheaths precedes faster elongation. Our data implicate local Ca2+ signaling in regulating distinct stages of myelination.
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