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Research
General Information
ZIRC
ZFIN ID: ZDB-LAB-140417-2
Kizil Lab, Mechanisms of induced Plasticity of the Vertebrate Brain
PI/Director: Kizil, Caghan
Contact Person:
Email: caghan.kizil@dzne.de
URL: http://www.dzne.de/kizil
Address: German Center for Neurodegenerative Diseases (DZNE) Dresden within Helmholtz Association, DFG-Center for Regenerative Therapies Dresden (CRTD), Cluster of Excellence, TU Dresden Fetscherstraße 105, 01307 Dresden, Germany
Country: Germany
Phone: +49(0)351 458 82315
Fax: +49(0)351 458 82309
Line Designation: ced


GENOMIC FEATURES ORIGINATING FROM THIS LAB
Show all 2 genomic features


STATEMENT OF RESEARCH INTERESTS
The main motivation for our research group at DZNE in Dresden is to understand what it takes in terms of molecular programs for zebrafish brain to regenerate itself after various ways of neuronal loss including traumatic injuries and neurodegeneration.


LAB MEMBERS
Bhattarai, Prabesh Graduate Student Cosacak, Mehmet Ilyas Graduate Student Papadimitriou, Christos Graduate Student
Brandt, Kerstin Technical Staff Fischer, Susan Administrative Staff Hopfe, Kristin Administrative Staff
Fore, Stephanie Kayisoglu, Ozge Wistorf, Sabrina


ZEBRAFISH PUBLICATIONS OF LAB MEMBERS x
Celikkaya, H., Cosacak, M.I., Papadimitriou, C., Popova, S., Bhattarai, P., Biswas, S.N., Siddiqui, T., Wistorf, S., Nevado-Alcalde, I., Naumann, L., Mashkaryan, V., Brandt, K., Freudenberg, U., Werner, C., Kizil, C. (2019) GATA3 Promotes the Neural Progenitor State but Not Neurogenesis in 3D Traumatic Injury Model of Primary Human Cortical Astrocytes. Frontiers in Cellular Neuroscience. 13:23
Reinhardt, L., Kordes, S., Reinhardt, P., Glatza, M., Baumann, M., Drexler, H.C.A., Menninger, S., Zischinsky, G., Eickhoff, J., Fröb, C., Bhattarai, P., Arulmozhivarman, G., Marrone, L., Janosch, A., Adachi, K., Stehling, M., Anderson, E.N., Abo-Rady, M., Bickle, M., Pandey, U.B., Reimer, M.M., Kizil, C., Schöler, H.R., Nussbaumer, P., Klebl, B., Sterneckert, J.L. (2019) Dual Inhibition of GSK3β and CDK5 Protects the Cytoskeleton of Neurons from Neuroinflammatory-Mediated Degeneration In Vitro and In Vivo. Stem Cell Reports. 12(3):502-517
Kizil, C., Bhattarai, P. (2018) Is Alzheimer's Also a Stem Cell Disease? - The Zebrafish Perspective. Frontiers in cell and developmental biology. 6:159
Kizil, C. (2018) Mechanisms of Pathology-Induced Neural Stem Cell Plasticity and Neural Regeneration in Adult Zebrafish Brain. Current pathobiology reports. 6:71-77
Bhattarai, P., Thomas, A.K., Cosacak, M.I., Papadimitriou, C., Mashkaryan, V., Zhang, Y., Kizil, C. (2017) Modeling Amyloid-β42 Toxicity and Neurodegeneration in Adult Zebrafish Brain. Journal of visualized experiments : JoVE. (128)
Cosacak, M.I., Bhattarai, P., Bocova, L., Dzewas, T., Mashkaryan, V., Papadimitriou, C., Brandt, K., Hollak, H., Antos, C.L., Kizil, C. (2017) Human TAUP301L overexpression results in TAU hyperphosphorylation without neurofibrillary tangles in adult zebrafish brain.. Scientific Reports. 7:12959
Singh, S.P., Janjuha, S., Hartmann, T., Kayisoglu, Ö., Konantz, J., Birke, S., Murawala, P., Alfar, E.A., Murata, K., Eugster, A., Tsuji, N., Morrissey, E.R., Brand, M., Ninov, N. (2017) Different developmental histories of beta-cells generate functional and proliferative heterogeneity during islet growth. Nature communications. 8:664
Bhattarai, P., Thomas, A.K., Zhang, Y., Kizil, C. (2017) The effects of aging on Amyloid-β42-induced neurodegeneration and regeneration in adult zebrafish brain. Neurogenesis (Austin, Tex.). 4:e1322666
Reiten, I., Uslu, F.E., Fore, S., Pelgrims, R., Ringers, C., Diaz Verdugo, C., Hoffman, M., Lal, P., Kawakami, K., Pekkan, K., Yaksi, E., Jurisch-Yaksi, N. (2017) Motile-Cilia-Mediated Flow Improves Sensitivity and Temporal Resolution of Olfactory Computations. Current biology : CB. 27(2):166-174
Bhattarai, P., Thomas, A.K., Cosacak, M.I., Papadimitriou, C., Mashkaryan, V., Froc, C., Reinhardt, S., Kurth, T., Dahl, A., Zhang, Y., Kizil, C. (2016) IL4/STAT6 Signaling Activates Neural Stem Cell Proliferation and Neurogenesis upon Amyloid-β42 Aggregation in Adult Zebrafish Brain. Cell Reports. 17:941-948
Tincer, G., Mashkaryan, V., Bhattarai, P., Kizil, C. (2016) Neural stem/progenitor cells in Alzheimer's disease. The Yale journal of biology and medicine. 89:23-35
Kizil, C., Iltzsche, A., Thomas, A.K., Bhattarai, P., Zhang, Y., Brand, M. (2015) Efficient cargo delivery into adult brain tissue using short cell-penetrating peptides. PLoS One. 10:e0124073
Kizil, C., Kyritsis, N., Brand, M. (2015) Effects of inflammation on stem cells: together they strive?. EMBO reports. 16(4):416-426
Cosacak, M.I., Papadimitriou, C., Kizil, C. (2015) Regeneration, Plasticity, and Induced Molecular Programs in Adult Zebrafish Brain. BioMed Research International. 2015:769763
Kizil, C., Küchler, B., Yan, J.J., Özhan, G., Moro, E., Argenton, F., Brand, M., Weidinger, G., Antos, C.L. (2014) Simplet/Fam53b is required for Wnt signal transduction by regulating β-catenin nuclear localization. Development (Cambridge, England). 141:3529-39
Kizil, C., Iltzsche, A., Kaslin, J., and Brand, M. (2013) Micromanipulation of gene expression in the adult zebrafish brain using cerebroventricular microinjection of morpholino oligonucleotides. Journal of visualized experiments : JoVE. (75):e50415
Kizil, C., Kyritsis, N., Dudczig, S., Kroehne, V., Freudenreich, D., Kaslin, J., and Brand, M. (2012) Regenerative Neurogenesis from Neural Progenitor Cells Requires Injury-Induced Expression of Gata3. Developmental Cell. 23(6):1230-1237
Kyritsis, N., Kizil, C., Zocher, S., Kroehne, V., Kaslin, J., Freudenreich, D., Iltzsche, A., and Brand, M. (2012) Acute Inflammation Initiates the Regenerative Response in the Adult Zebrafish Brain. Science (New York, N.Y.). 338(6112):1353-1356
Kizil, C., Dudczig, S., Kyritsis, N., Machate, A., Blaesche, J., Kroehne, V., and Brand, M. (2012) The chemokine receptor cxcr5 regulates the regenerative neurogenesis response in the adult zebrafish brain. Neural Development. 7(1):27
Kizil, C., Kaslin, J., Kroehne, V., and Brand, M. (2012) Adult neurogenesis and brain regeneration in zebrafish. Developmental Neurobiology. 72(3):429-461
Kizil, C., and Brand, M. (2011) Cerebroventricular Microinjection (CVMI) into Adult Zebrafish Brain Is an Efficient Misexpression Method for Forebrain Ventricular Cells. PLoS One. 6(11):e27395
Kizil, C., Otto, G.W., Geisler, R., Nüsslein-Volhard, C., and Antos, C.L. (2009) Simplet controls cell proliferation and gene transcription during zebrafish caudal fin regeneration. Developmental Biology. 325(2):329-340
Kizil, C. (2009) Characterization of fam53b, simplet (smp) gene in caudal fin regeneration and embryonic development of zebrafish (Danio rerio). Ph.D. Thesis. :126p