PUBLICATION

Mechanisms of Pathology-Induced Neural Stem Cell Plasticity and Neural Regeneration in Adult Zebrafish Brain

Authors
Kizil, C.
ID
ZDB-PUB-180626-2
Date
2018
Source
Current pathobiology reports   6: 71-77 (Review)
Registered Authors
Kizil, Caghan
Keywords
Adult zebrafish brain, Induced plasticity, Neural stem cell, Neurodegeneration, Neurogenesis, Regeneration
MeSH Terms
none
PubMed
29938129 Full text @ Curr Pathobiol Rep
Citation
Kizil, C. (2018) Mechanisms of Pathology-Induced Neural Stem Cell Plasticity and Neural Regeneration in Adult Zebrafish Brain. Current pathobiology reports. 6:71-77.
Abstract
Purpose of the review The purpose of this study is to review the current knowledge on the damage-induced molecular programs that underlie the regenerative ability in zebrafish brain.
Recent findings Neural stem cells are the reservoir for new neurons during development and regeneration of the vertebrate brains. Pathological conditions such as neurodegenerative diseases hamper neural stem cell plasticity and neurogenic outcome in humans, whereas adult zebrafish brain can enhance proliferation and neurogenic capacity of its neural stem cells despite the incipient pathology. Evidence suggests that zebrafish uses damage-induced molecular programs to enable neural stem cells to efficiently initiate regeneration. Since this aptitude may be harnessed for regenerative therapies in human brain, understanding the molecular programs regulating neural stem cell proliferation and quiescence in zebrafish is of utmost importance for clinical efforts.
Summary Specific molecular programs that are different than those in the homeostatic conditions regulate adult zebrafish neural stem cell plasticity and the regenerative capacity after injury and neurodegeneration. These programs can serve as candidates for stem cell-based regenerative therapies in humans.
Genes / Markers
Figures
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Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Mapping
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