ZFIN ID: ZDB-LAB-090114-1
Ting Xi Liu Lab
PI/Director: Liu, Ting Xi
Co-PI / Senior
Researcher:
Deng, Min
Contact Person: Deng, Min
Email: mdeng@sibs.ac.cn
URL:
Address: Building 1, Room 408 225 South Chong Qing Road Institute of Health Sciences Shanghai Institutes of Biological Sciences Chinese Academy of Sciences & Shanghai Jiao Tong University School of Medicine Shanghai 200025
Country: China
Phone: 86-21-63857025
Fax: 86-21-63857029
Line Designation: rj


GENOMIC FEATURES ORIGINATING FROM THIS LAB
Show all 41 genomic features


STATEMENT OF RESEARCH INTERESTS
Our group takes advantage of zebrafish (Danio rerio), a powerful vertebrate model organism to dissect the developmental pathways deregulated in human leukemia and cancers. We are now interested in: 1) Signal transduction networks, epigenetic and microRNA regulatory pathways involved in the self-renewal and migration of normal hematopoietic stem cells, leukemia stem cells and red blood cells; 2) Molecular mechanisms underlying chemotactic movement of inflammatory blood cells and metastasis of cancer stem cells. 3) Whole animal-based high throughput screen with zebrafish for potential therapeutic drugs.


LAB MEMBERS
Chen, Yi Research Staff Dong, Mei Research Staff Zhu, Kang-Yong Research Staff
Qian, Min Administrative Staff


ZEBRAFISH PUBLICATIONS OF LAB MEMBERS x
Yu, S.H., Zhu, K.Y., Zhang, F., Wang, J., Yuan, H., Chen, Y., Jin, Y., Dong, M., Wang, L., Jia, X.E., Gao, L., Dong, Z.W., Ren, C.G., Chen, L.T., Huang, Q.H., Deng, M., Zon, L.I., Zhou, Y., Zhu, J., Xu, P.F., Liu, T.X. (2018) The histone demethylase Jmjd3 regulates zebrafish myeloid development by promoting spi1 expression. Biochimica et biophysica acta. 1861(2):106-116
Wagner, K.D., Ying, Y., Leong, W., Jiang, J., Hu, X., Chen, Y., Michiels, J.F., Lu, Y., Gilson, E., Wagner, N., Ye, J. (2017) The differential spatiotemporal expression pattern of shelterin genes throughout lifespan. Aging. 9(4):1219-1232
Ma, A.C., Chen, Y., Blackburn, P.R., Ekker, S.C. (2016) TALEN-Mediated Mutagenesis and Genome Editing. Methods in molecular biology (Clifton, N.J.). 1451:17-30
Shu, L.P., Zhou, Z.W., Zhou, T., Deng, M., Dong, M., Chen, Y., Fu, Y.F., Jin, Y., Zhou, S.F., He, Z.X. (2015) Ectopic expression of Hoxb4a in hemangioblasts promotes hematopoietic development in early embryogenesis of zebrafish. Clinical and experimental pharmacology & physiology. 42:1275-86
Jia, X.E., Ma, K., Xu, T., Gao, L., Wu, S., Fu, C., Zhang, W., Wang, Z., Liu, K., Dong, M., Jing, C., Ren, C., Dong, Z., Chen, Y., Jin, Y., Huang, Q., Chang, X., Deng, M., Li, L., Luo, L., Zhu, J., Dang, Y., Chang, H.C., Zon, L.I., Zhou, Y., Chen, S., Pan, W. (2015) Mutation of kri1l causes definitive hematopoiesis failure via PERK-dependent excessive autophagy induction. Cell Research. 25(8):946-62
Gao, L., Li, D., Ma, K., Zhang, W., Xu, T., Fu, C., Jing, C., Jia, X., Wu, S., Sun, X., Dong, M., Deng, M., Chen, Y., Zhu, W., Peng, J., Wan, F., Zhou, Y., Zon, L.I., Pan, W. (2015) TopBP1 Governs Hematopoietic Stem/Progenitor Cells Survival in Zebrafish Definitive Hematopoiesis. PLoS Genetics. 11:e1005346
Ye, B.X., Deng, X., Shao, L.D., Lu, Y., Xiao, R., Liu, Y.J., Jin, Y., Xie, Y.Y., Zhao, Y., Luo, L.F., Ma, S., Gao, M., Zhang, L.R., He, J., Zhang, W.N., Chen, Y., Xia, C.F., Deng, M., Liu, T.X., Zhao, Q.S., Chen, S.J., Chen, Z. (2015) Vibsanin B Preferentially Targets HSP90β, Inhibits Interstitial Leukocyte Migration, and Ameliorates Experimental Autoimmune Encephalomyelitis. Journal of immunology (Baltimore, Md. : 1950). 194(9):4489-97
Yuan, H., Zhang, T., Liu, X., Deng, M., Zhang, W., Wen, Z., Chen, S., Chen, Z., de The, H., Zhou, J., Zhu, J. (2015) Sumoylation of CCAAT/enhancer-binding protein α is implicated in hematopoietic stem/progenitor cell development through regulating runx1 in zebrafish. Scientific Reports. 5:9011
Liu, X., Jia, X., Yuan, H., Ma, K., Chen, Y., Jin, Y., Deng, M., Pan, W., Chen, S., Chen, Z., de The, H., Zon, L.I., Zhou, Y., Zhou, J., Zhu, J. (2015) DNA methyltransferase 1 functions through C/ebpa to maintain hematopoietic stem and progenitor cells in zebrafish. Journal of Hematology & Oncology. 8:15
Fan, H.B., Liu, Y.J., Wang, L., Du, T.T., Dong, M., Gao, L., Meng, Z.Z., Jin, Y., Chen, Y., Deng, M., Yang, H.T., Jing, Q., Gu, A.H., Liu, T.X., Zhou, Y. (2014) miR-142-3p acts as an essential modulator of neutrophil development in zebrafish. Blood. 124(8):1320-30
Du, T.T., Xu, P.F., Dong, Z.W., Fan, H.B., Jin, Y., Dong, M., Chen, Y., Pan, W.J., Ren, R.B., Liu, T.X., Deng, M., Huang, Q.H. (2014) Setdb2 controls convergence and extension movements during zebrafish gastrulation by transcriptional regulation of dvr1. Developmental Biology. 392(2):233-44
Li, W., Chen, J., Deng, M., Jing, Q. (2014) The zebrafish Tie2 signaling controls tip cell behaviors and acts synergistically with Vegf pathway in developmental angiogenesis. Acta Biochimica et Biophysica Sinica. 46(8):641-6
Chen, L.T., Liang, W.X., Chen, S., Li, R.K., Tan, J.L., Xu, P.F., Luo, L.F., Wang, L., Yu, S.H., Meng, G., Li, K.K., Liu, T.X., Chen, Z., Chen, S.J. (2014) Functional and molecular features of the calmodulin-interacting protein IQCG required for haematopoiesis in zebrafish. Nature communications. 5:3811
Dong, Z.W., Ren, C.G., Xia, Y., Su, D., Du, T.T., Fan, H.B., Yuan, H., Wang, L., Dong, M., Li, W.C., Jin, Y., Chen, Y., Deng, M., Liu, T.X., Gu, A.H., Zhou, Y. (2014) Pten regulates homeostasis and inflammation-induced migration of myelocytes in zebrafish. Journal of Hematology & Oncology. 7:17
Chen, S., Luo, G.R., Li, T., Liu, T.X., and Le, W. (2013) Correlation of Nr4a2 Expression with the Neuron Progenitors in Adult Zebrafish Brain. Journal of molecular neuroscience : MN. 51(3):719-23
Wang, L., Fu, C., Fan, H., Du, T., Dong, M., Chen, Y., Jin, Y., Zhou, Y., Deng, M., Gu, A., Jing, Q., Liu, T., and Zhou, Y. (2013) miR-34b regulates multiciliogenesis during organ formation in zebrafish. Development (Cambridge, England). 140(13):2755-2764
Ren, C.G., Wang, L., Jia, X.E., Liu, Y.J., Dong, Z.W., Jin, Y., Chen, Y., Deng, M., Zhou, Y., Zhou, Y., Ren, R.B., Pan, W.J., and Liu, T.X. (2013) Activated N-Ras signaling regulates arterial-venous specification in zebrafish. Journal of Hematology & Oncology. 6:34
Liu, Y.J., Fan, H.B., Jin, Y., Ren, C.G., Jia, X.E., Wang, L., Chen, Y., Dong, M., Zhu, K.Y., Dong, Z.W., Ye, B.X., Zhong, Z., Deng, M., Liu, T.X., and Ren, R. (2013) Cannabinoid receptor 2 suppresses leukocyte inflammatory migration by modulating the JNK/c-Jun/Alox5 pathway. The Journal of biological chemistry. 288(19):13551-62
Jing, C.B., Chen, Y., Dong, M., Peng, X.L., Jia, X.E., Gao, L., Ma, K., Deng, M., Liu, T.X., Zon, L.I., Zhu, J., Zhou, Y., and Zhou, Y. (2013) Phospholipase c gamma-1 is required for granulocyte maturation in zebrafish. Developmental Biology. 374(1):24-31
Langenbacher, A.D., Huang, J., Chen, Y., and Chen, J.N. (2012) Sodium pump activity in the yolk syncytial layer regulates zebrafish heart tube morphogenesis. Developmental Biology. 362(2):263-270
Zhou, T., Wang, L., Zhu, K.Y., Dong, M., Xu, P.F., Chen, Y., Chen, S.J., Chen, Z., Deng, M., and Liu, T.X. (2011) Dominant-negative C/ebpalpha and polycomb group protein Bmi1 extends short-lived hematopoietic stem/progenitor cells lifespan and induces lethal dyserythropoiesis. Blood. 118(14):3842-52
Yuan, H., Zhou, J., Deng, M., Zhang, Y., Chen, Y., Jin, Y., Zhu, J., Chen, S.J., The, H.D., Chen, Z., Liu, T.X., and Zhu, J. (2011) Sumoylation of CCAAT/enhancer-binding protein α promotes the biased primitive hematopoiesis of zebrafish. Blood. 117(26):7014-7020
Zou, J., Li, W.Q., Li, Q., Li, X.Q., Zhang, J.T., Liu, G.Q., Chen, J., Qiu, X.X., Tian, F.J., Wang, Z.Z., Zhu, N., Qin, Y.W., Shen, B., Liu, T.X., and Jing, Q. (2011) Two Functional MicroRNA-126s Repress a Novel Target Gene p21-Activated Kinase 1 to Regulate Vascular Integrity in Zebrafish. Circulation research. 108(2):201-209
Li, S., Yin, M., Liu, S., Chen, Y., Yin, Y., Liu, T., and Zhou, J. (2010) Expression of ventral diencephalon-enriched genes in zebrafish. Developmental dynamics : an official publication of the American Association of Anatomists. 239(12):3368-3379
Fu, C.T., Zhu, K.Y., Mi, J.Q., Liu, Y.F., Murray, S.T., Fu, Y.F., Ren, C.G., Dong, Z.W., Liu, Y.J., Dong, M., Jin, Y., Chen, Y., Deng, M., Zhang, W., Chen, B., Breslin, P., Chen, S.J., Chen, Z., Becker, M.W., Zhu, J., Zhang, J.W., and Liu, T.X. (2010) An evolutionarily conserved PTEN-C/EBP{alpha}-CTNNA1 axis controls myeloid development and transformation. Blood. 115(23):4715-4724
Xu, P.F., Zhu, K.Y., Jin, Y., Chen, Y., Sun, X.J., Deng, M., Chen, S.J., Chen, Z., and Liu, T.X. (2010) Setdb2 restricts dorsal organizer territory and regulates left-right asymmetry through suppressing fgf8 activity. Proc. Natl. Acad. Sci. USA. 107(6):2521-2526
Yuan, H., Zhou, J., Deng, M., Liu, X., Bras, M.L., The, H.D., Chen, S.J., Chen, Z., Liu, T.X., and Zhu, J. (2010) Small ubiquitin-related modifier paralogs are indispensable but functionally redundant during early development of zebrafish. Cell Research. 20(2):185-196
Zhang, Y., Chen, F.Y., and Deng, M. (2009) Research progress of zebrafish as a model system for hematological neoplasms. Yi chuan = Hereditas. 31(9):889-895
Dong, M., Fu, Y.F., Du, T.T., Jing, C.B., Fu, C.T., Chen, Y., Jin, Y., Deng, M., and Liu, T.X. (2009) Heritable and lineage-specific gene knockdown in zebrafish embryo. PLoS One. 4(7):e6125
Du, T.T., Fu, Y.F., Dong, M., Wang, L., Fan, H.B., Chen, Y., Jin, Y., Chen, S.J., Chen, Z., Deng, M., Huang, Q.H., and Liu, T.X. (2009) Experimental validation and complexity of miRNA-mRNA target interaction during zebrafish primitive erythropoiesis. Biochemical and Biophysical Research Communications. 381(4):688-693
Fu, Y.F., Du, T.T., Dong, M., Zhu, K.Y., Jing, C.B., Zhang, Y., Wang, L., Fan, H.B., Chen, Y., Jin, Y., Yue, G.P., Chen, S.J., Chen, Z., Huang, Q.H., Jing, Q., Deng, M., and Liu, T.X. (2009) Mir-144 selectively regulates embryonic {alpha}-hemoglobin synthesis during primitive erythropoiesis. Blood. 113(6):1340-1349
Luo, G.R., Chen, Y., Li, X.P., Liu, T.X., and Le, W.D. (2008) Nr4a2 is essential for the differentiation of dopaminergic neurons during zebrafish embryogenesis. Molecular and Cellular Neuroscience. 39(2):202-210
Xie, J., Wang, W., Liu, T., Deng, M., and Ning, G. (2008) Spatio-temporal expression of Chromogranin A during zebrafish embryogenesis. The Journal of endocrinology. 198(3):451-458
Wang, L., Zhang, Y., Zhou, T., Fu, Y.F., Du, T.T., Jin, Y., Chen, Y., Ren, C.G., Peng, X.L., Deng, M., and Liu, T.X. (2008) Functional characterization of lmo2-Cre transgenic zebrafish. Developmental dynamics : an official publication of the American Association of Anatomists. 237(8):2139-2146
Zhang, Y., Bai, X.T., Zhu, K.Y., Jin, Y., Deng, M., Le, H.Y., Fu, Y.F., Chen, Y., Zhu, J., Look, A.T., Kanki, J., Chen, Z., Chen, S.J., and Liu, T.X. (2008) In Vivo Interstitial Migration of Primitive Macrophages Mediated by JNK-Matrix Metalloproteinase 13 Signaling in Response to Acute Injury. Journal of immunology (Baltimore, Md. : 1950). 181(3):2155-2164
Le, H.Y., Zhang, Y., Liu, H., Ma, L.H., Jin, Y., Huang, Q.H., Chen, Y., Deng, M., Chen, Z., Chen, S.J., and Liu, T. (2008) EENA promotes myeloid proliferation through stimulating ERK1/2 phosphorylation in zebrafish. The Journal of biological chemistry. 283(25):17652-17661
Sun, X.J., Xu, P.F., Zhou, T., Hu, M., Fu, C.T., Zhang, Y., Jin, Y., Chen, Y., Chen, S.J., Huang, Q.H., Liu, T.X., and Chen, Z. (2008) Genome-Wide Survey and Developmental Expression Mapping of Zebrafish SET Domain-Containing Genes. PLoS One. 3(1):e1499
Liu, T.X., Rhodes, J., Deng, M., Hsu, K., Radomska, H.S., Kanki, J.P., Tenen, D.G., and Look, A.T. (2007) Dominant-interfering C/EBPalpha stimulates primitive erythropoiesis in zebrafish. Experimental hematology. 35(2):230-239
Mathias, J.R., Perrin, B.J., Liu, T.X., Kanki, J., Look, A.T., and Huttenlocher, A. (2006) Resolution of inflammation by retrograde chemotaxis of neutrophils in transgenic zebrafish. Journal of Leukocyte Biology. 80(6):1281-1288
Berghmans,, S., Murphey, R.D., Wienholds, E., Neuberg, D., Kutok, J.L., Fletcher, C.D., Morris, J.P., Liu, T.X., Schulte-Merker, S., Kanki, J.P., Plasterk, R., Zon, L.I., and Look, A.T. (2005) tp53 mutant zebrafish develop malignant peripheral nerve sheath tumors. Proc. Natl. Acad. Sci. USA. 102(2):407-412
Rhodes, J., Hagen, A., Hsu, K., Deng, M., Liu, T.X., Look, A.T., and Kanki, J.P. (2005) Interplay of pu.1 and gata1 determines myelo-erythroid progenitor cell fate in zebrafish. Developmental Cell. 8(1):97-108
Song, H.D., Sun, X.J., Deng, M., Zhang, G.W., Zhou, Y., Wu, X.Y., Sheng, Y., Chen, Y., Ruan, Z., Jiang, C.L., Fan, H.Y., Zon, L.I., Kanki, J.P., Liu, T.X., Look, A.T., and Chen, Z. (2004) Hematopoietic gene expression profile in zebrafish kidney marrow. Proc. Natl. Acad. Sci. USA. 101(46):16240-16245
Hsu, K., Traver, D., Kutok, J.L., Hagen, A., Liu, T.X., Paw, B.H., Rhodes, J., Berman, J., Zon, L.I., Kanki, J.P., and Look, A.T. (2004) The pu.1 promoter drives myeloid gene expression in zebrafish. Blood. 104(5):1291-1297
Liu, T.X., Howlett, N.G., Deng, M., Langenau, D.M., Hsu, K., Rhodes, J., Kanki, J.P., D'Andrea, A.D., and Look, A.T. (2003) Knockdown of zebrafish fancd2 causes developmental abnormalities via p53-dependent apoptosis. Developmental Cell. 5(6):903-914
Liu, T.-X., Zhou, Y., Kanki, J.P., Deng, M., Rhodes, J., Yang, H.-W., Sheng, X.-M., Zon, L.I., and Look, A.T. (2002) Evolutionary conservation of zebrafish linkage group 14 with frequently deleted regions of human chromosome 5 in myeloid malignancies. Proc. Natl. Acad. Sci. USA. 99(9):6136-6141
Hsu, K., Rhodes, J., Liu, T.X., Kanki, J.P., Paw, B., Zon, L.I., and Look, A.T. (2001) Pu.1 is expressed by early granulocytic progenitors in the zebrafish. Blood. 98(11):63
Liu, T.X., Rhodes, J., Kanki, J.P., Hsu, K., Radomska, H.S., Deng, M., Piao, H.Y., Zhou, Y., Tenen, D.G., and Zon, L.I. (2001) The cloning and characterization of zebrafish CCAAT/enhancer binding protein alpha. Blood. 98(11):2924
Song, H.D., Liu, T.X., Wu, X.Y., Shun, X.J., Zhang, Q.H., Chen, S.J., Zhou, Y., Chen, Z., Look, T.A., and Zon, L.I. (2001) Gene expression profiling in kidney of zebrafish's hematopoietic tissue. Blood. 98(11):4137
Bennett, C.M., Kanki, J.P., Rhodes, J., Liu, T.X., Paw, B.H., Kieran, M.W., Langenau, D.M., Delahaye-Brown, A., Zon, L.I., Fleming, M.D., and Look, A.T. (2001) Myelopoiesis in the zebrafish, Danio rerio. Blood. 98(3):643-651
Bennett, C.M., Fleming, M.D., Kanki, J.P., Rhodes, J., Delahaye-Brown, A., Langenau, D.M., Liu, T.X., Paw, B.H., Zon, L.I., and Look, A.T. (2000) Genetic analysis of myelopoiesis the zebrafish. Blood. 96(11):4177
Liu, T.X., Zhou, Y., Kanki, J.P., Zon, L.I., and Look, A.T. (2000) Syntenic region shared by zebrafish and patients with 5q-syndrome. Blood. 96(11):380
Rhodes, J., Bennett, C.M., Kanki, J.P., Liu, T.X., Paw, B.H., Zon, L.I., and Look, A.T. (2000) Molecular analysis of zebrafish myelopoiesis. Blood. 96(11):3483