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Research
General Information
ZIRC
ZFIN ID: ZDB-LAB-060130-1
Parsons Lab
PI/Director: Parsons, Michael
Contact Person: Parsons, Michael
Email: mparson1@uci.edu
URL: http://devcell.bio.uci.edu/faculty/michael-parsons/
Address: Department of Developmental and Cell Biology 4101 Natural Sciences II University of California, Irvine 92697
Country: United States
Phone: 949 824 8728
Fax:
Line Designation: ir


GENOMIC FEATURES ORIGINATING FROM THIS LAB
Show all 32 genomic features


STATEMENT OF RESEARCH INTERESTS
We are interested in the development and regeneration of the zebrafish islet. Using a drug inducible system, we can specifically ablate beta cells of the islet and study their regeneration over time. We are now focusing on ascertaining the mechanism behind beta cell regeneration and identifying beta cell progenitors.


LAB MEMBERS


ZEBRAFISH PUBLICATIONS OF LAB MEMBERS x
Zhang, D., Gates, K.P., Barske, L., Wang, G., Lancman, J.J., Zeng, X.I., Groff, M., Wang, K., Parsons, M.J., Crump, J.G., Dong, P.D.S. (2017) Endoderm Jagged induces liver and pancreas duct lineage in zebrafish. Nature communications. 8:769
Huang, W., Beer, R.L., Delaspre, F., Wang, G., Edelman, H.E., Park, H., Azuma, M., Parsons, M.J. (2016) Sox9b is a mediator of retinoic acid signaling restricting endocrine progenitor differentiation. Developmental Biology. 418(1):28-39
Johnson, K., Barragan, J., Bashiruddin, S., Smith, C.J., Tyrrell, C., Parsons, M.J., Doris, R., Kucenas, S., Downes, G.B., Velez, C.M., Schneider, C., Sakai, C., Pathak, N., Anderson, K., Stein, R., Devoto, S.H., Mumm, J.S., Barresi, M.J. (2016) Gfap-positive radial glial cells are an essential progenitor population for later-born neurons and glia in the zebrafish spinal cord. Glia. 64(7):1170-89
Delaspre, F., Beer, R.L., Rovira, M., Huang, W., Wang, G., Gee, S., Vitery, M.D., Wheelan, S.J., Parsons, M.J. (2015) Centroacinar cells are progenitors that contribute to endocrine pancreas regeneration. Diabetes. 64(10):3499-509
Fischer, A., Wolman, M., Granato, M., Parsons, M., McCallion, A.S., Proescher, J., English, E. (2015) Carbamate nerve agent prophylatics exhibit distinct toxicological effects in the zebrafish embryo model. Neurotoxicology and teratology. 50:1-10
Wang, Y.J., Park, J.T., Parsons, M.J., Leach, S.D. (2015) Fate mapping of ptf1a-expressing cells during pancreatic organogenesis and regeneration in zebrafish. Developmental dynamics : an official publication of the American Association of Anatomists. 244(6):724-35
Park, J.T., Johnson, N., Liu, S., Levesque, M., Wang, Y.J., Ho, H., Huso, D., Maitra, A., Parsons, M.J., Prescott, J.D., Leach, S.D. (2015) Differential in vivo tumorigenicity of diverse KRAS mutations in vertebrate pancreas: A comprehensive survey. Oncogene. 34(21):2801-6
Huang, W., Wang, G., Delaspre, F., Vitery, M.D., Beer, R.L., Parsons, M.J. (2014) Retinoic acid plays an evolutionarily conserved and biphasic role in pancreas development. Developmental Biology. 394(1):83-93
Quillien, A., Moore, J.C., Shin, M., Siekmann, A.F., Smith, T., Pan, L., Moens, C.B., Parsons, M.J., Lawson, N.D. (2014) Distinct Notch signaling outputs pattern the developing arterial system. Development (Cambridge, England). 141:1544-52
Subedi, A., Macurak, M., Gee, S.T., Monge, E., Goll, M.G., Potter, C.J., Parsons, M.J., and Halpern, M.E. (2014) Adoption of the Q transcriptional regulatory system for zebrafish transgenesis. Methods (San Diego, Calif.). 66(3):433-40
Matsuda, H., Parsons, M.J., and Leach, S.D. (2013) Aldh1-expressing endocrine progenitor cells regulate secondary islet formation in larval zebrafish pancreas. PLoS One. 8(9):e74350
Provost, E., Wehner, K.A., Zhong, X., Ashar, F., Nguyen, E., Green, R., Parsons, M.J., and Leach, S.D. (2012) Ribosomal biogenesis genes play an essential and p53-independent role in zebrafish pancreas development. Development (Cambridge, England). 139(17):3232-3241
Manfroid, I., Ghaye, A., Naye, F., Detry, N., Palm, S., Pan, L., Ma, T.P., Huang, W., Rovira, M., Martial, J.A., Parsons, M.J., Moens, C.B., Voz, M.L., and Peers, B. (2012) Zebrafish sox9b is crucial for hepatopancreatic duct development and pancreatic endocrine cell regeneration. Developmental Biology. 366(2):268-278
Kague, E., Gallagher, M., Burke, S., Parsons, M., Franz-Odendaal, T., and Fisher, S. (2012) Skeletogenic fate of zebrafish cranial and trunk neural crest. PLoS One. 7(11):e47394
Walker, S.L., Ariga, J., Mathias, J.R., Coothankandaswamy, V., Xie, X., Distel, M., Köster, R.W., Parsons, M.J., Bhalla, K.N., Saxena, M.T., and Mumm, J.S. (2012) Automated reporter quantification in vivo: high-throughput screening method for reporter-based assays in zebrafish. PLoS One. 7(1):e29916
Rovira, M., Huang, W., Yusuff, S., Shim, J.S., Ferrante, A.A., Liu, J.O., and Parsons, M.J. (2011) Chemical screen identifies FDA-approved drugs and target pathways that induce precocious pancreatic endocrine differentiation. Proceedings of the National Academy of Sciences of the United States of America. 108(48):19264-9
Wang, Y., Rovira, M., Yusuff, S., and Parsons, M.J. (2011) Genetic inducible fate mapping in larval zebrafish reveals origins of adult insulin-producing {beta}-cells. Development (Cambridge, England). 138(4):609-617
Parsons, K.J., Andreeva, V., James Cooper, W., Yelick, P.C., and Craig Albertson, R. (2011) Morphogenesis of the zebrafish jaw: development beyond the embryo. Methods in cell biology. 101:225-248
Williams, P.R., Suzuki, S.C., Yoshimatsu, T., Lawrence, O.T., Waldron, S.J., Parsons, M.J., Nonet, M.L., and Wong, R.O. (2010) In vivo development of outer retinal synapses in the absence of glial contact. The Journal of neuroscience : the official journal of the Society for Neuroscience. 30(36):11951-11961
Kani, S., Bae, Y.K., Shimizu, T., Tanabe, K., Satou, C., Parsons, M.J., Scott, E., Higashijima, S.I., and Hibi, M. (2010) Proneural gene-linked neurogenesis in zebrafish cerebellum. Developmental Biology. 343(1-2):1-17
Montgomery, J.E., Parsons, M.J., and Hyde, D.R. (2010) A novel model of retinal ablation demonstrates that the extent of rod cell death regulates the origin of the regenerated zebrafish rod photoreceptors. The Journal of comparative neurology. 518(6):800-814
Parsons, M.J., Pisharath, H., Yusuff, S., Moore, J.C., Siekmann, A.F., Lawson, N., and Leach, S.D. (2009) Notch-responsive cells initiate the secondary transition in larval zebrafish pancreas. Mechanisms of Development. 126(10):898-912
Moss, J.B., Koustubhan, P., Greenman, M., Parsons, M.J., Walter, I., and Moss, L.G. (2009) Regeneration of the Pancreas in Adult Zebrafish. Diabetes. 58(8):1844-1851
Pisharath, H., and Parsons, M.J. (2009) Nitroreductase-mediated cell ablation in transgenic zebrafish embryos. Methods in molecular biology (Clifton, N.J.). 546:133-143
Halpern, M.E., Rhee, J., Goll, M.G., Akitake, C.M., Parsons, M., and Leach, S.D. (2008) Gal4/UAS transgenic tools and their application to zebrafish. Zebrafish. 5(2):97-110
Davison, J.M., Akitake, C.M., Goll, M.G., Rhee, J.M., Gosse, N., Baier, H., Halpern, M.E., Leach, S.D., and Parsons, M.J. (2007) Transactivation from Gal4-VP16 transgenic insertions for tissue-specific cell labeling and ablation in zebrafish. Developmental Biology. 304(2):811-824
Pisharath, H., Rhee, J.M., Swanson, M.A., Leach, S.D., and Parsons, M.J. (2007) Targeted ablation of beta cells in the embryonic zebrafish pancreas using E. coli nitroreductase. Mechanisms of Development. 124(3):218-229
Pollard, S.M., Parsons, M.J., Kamei, M., Kettleborough, R.N., Thomas, K.A., Pham, V.N., Bae, M.K., Scott, A., Weinstein, B.M., and Stemple, D.L. (2006) Essential and overlapping roles for laminin alpha chains in notochord and blood vessel formation. Developmental Biology. 289(1):64-76
Coutinho, P., Parsons, M.J., Thomas, K.A., Hirst, E.M., Saude, L., Campos, I., Williams, P.H., Stemple, D.L. (2004) Differential Requirements for COPI Transport during Vertebrate Early Development. Developmental Cell. 7(4):547-558
Feldman, B., Concha, M.L., Saude, L., Parsons, M.J., Adams, R.J., Wilson, S.W., and Stemple, D.L. (2002) Lefty antagonism of squint is essential for normal gastrulation. Current biology : CB. 12(24):2129-2135
Parsons, M.J., Campos, I., Hirst, E.M.A., and Stemple, D.L. (2002) Removal of dystroglycan causes severe muscular dystrophy in zebrafish embryos. Development (Cambridge, England). 129(14):3505-3512
Parsons, M.J., Pollard, S.M., Saude, L., Feldman, B., Coutinho, P., Hirst, E.M., and Stemple, D.L. (2002) Zebrafish mutants identify an essential role for laminins in notochord formation. Development (Cambridge, England). 129(13):3137-3146