ZFIN Lab: Boehm Lab

ZFIN ID: ZDB-LAB-001129-1

Boehm Lab

PI/Director:	Boehm, Tom
Contact Person:	Boehm, Tom
Email:	boehm@immunbio.mpg.de
URL:	http://www.immunbio.mpg.de/
Address:	Department of Developmental Immunology Max-Planck-Institute for Immunobiology Stuebeweg 51 D-79108 Freiburg GERMANY
Country:	Germany
Phone:	49-761-510-8328
Fax:	49-761-510-8323
Line Designation:	fr

GENOMIC FEATURES ORIGINATING FROM THIS LAB

Show all 31 genomic features

STATEMENT OF RESEARCH INTERESTS

LAB MEMBERS

Schorpp, Michael

ZEBRAFISH PUBLICATIONS OF LAB MEMBERS

Lawir, D.F., Soza-Ried, C., Iwanami, N., Siamishi, I., Bylund, G.O., O Meara, C., Sikora, K., Kanzler, B., Johansson, E., Schorpp, M., Cauchy, P., Boehm, T. (2024) Antagonistic interactions safeguard mitotic propagation of genetic and epigenetic information in zebrafish. Communications biology. 7:3131

Schorpp, M., Swann, J.B., Hess, I., Ho, H.C., Pietsch, T.W., Boehm, T. (2023) Foxn1 is not essential for T-cell development in teleosts. European journal of immunology. 53(12):e2350725

Hess, I., Sagar, ., O Meara, C., Grün, D., Schorpp, M., Boehm, T. (2022) Stage-specific and cell type-specific requirements of ikzf1 during haematopoietic differentiation in zebrafish. Scientific Reports. 12:2140121401

O'Meara, C.P., Guerri, L., Lawir, D.F., Mateos, F., Iconomou, M., Iwanami, N., Soza-Ried, C., Sikora, K., Siamishi, I., Giorgetti, O., Peter, S., Schorpp, M., Boehm, T. (2021) Genetic landscape of T cells identifies synthetic lethality for T-ALL. Communications biology. 4:1201

Venkatesh, B., Lee, A.P., Ravi, V., Maurya, A.K., Lian, M.M., Swann, J.B., Ohta, Y., Flajnik, M.F., Sutoh, Y., Kasahara, M., Hoon, S., Gangu, V., Roy, S.W., Irimia, M., Korzh, V., Kondrychyn, I., Lim, Z.W., Tay, B.H., Tohari, S., Kong, K.W., Ho, S., Lorente-Galdos, B., Quilez, J., Marques-Bonet, T., Raney, B.J., Ingham, P.W., Tay, A., Hillier, L.W., Minx, P., Boehm, T., Wilson, R.K., Brenner, S., Warren, W.C. (2020) Author Correction: Elephant shark genome provides unique insights into gnathostome evolution. Nature. 588:E15

Iwanami, N., Lawir, D.F., Sikora, K., O Meara, C., Takeshita, K., Schorpp, M., Boehm, T. (2020) Transgenerational inheritance of impaired larval T cell development in zebrafish. Nature communications. 11:4505

Lawir, D.F., Sikora, K., O'Meara, C.P., Schorpp, M., Boehm, T. (2020) Pervasive changes of mRNA splicing in upf1-deficient zebrafish identify rpl10a as a regulator of T cell development. Proceedings of the National Academy of Sciences of the United States of America. 117(27):15799-15808

Iwanami, N., Takeshita, K., Lawir, D.F., Suetake, I., Tajima, S., Sikora, K., Trancoso, I., ÓMeara, C., Siamishi, I., Takahama, Y., Furutani-Seiki, M., Kondoh, H., Yonezawa, Y., Schorpp, M., Boehm, T. (2020) Epigenetic Protection of Vertebrate Lymphoid Progenitor Cells by Dnmt1. iScience. 23:101260

Lawir, D.F., Hess, I., Sikora, K., Iwanami, N., Siamishi, I., Schorpp, M., Boehm, T. (2019) Evolutionary transition from degenerate to nonredundant cytokine signaling networks supporting intrathymic T cell development. Proceedings of the National Academy of Sciences of the United States of America. 116(52):26759-26767

Tenno, M., Kojo, S., Lawir, D.F., Hess, I., Shiroguchi, K., Ebihara, T., Endo, T.A., Muroi, S., Satoh, R., Kawamoto, H., Boehm, T., Taniuchi, I. (2018) Cbfβ2 controls differentiation of and confers homing capacity to prethymic progenitors. The Journal of experimental medicine. 215(2):595-610

Lawir, D.F., Iwanami, N., Schorpp, M., Boehm, T. (2017) A missense mutation in zbtb17 blocks the earliest steps of T cell differentiation in zebrafish. Scientific Reports. 7:44145

Iwanami, N., Hess, I., Schorpp, M., Boehm, T. (2017) Studying the adaptive immune system in zebrafish by transplantation of hematopoietic precursor cells. Methods in cell biology. 138:151-161

Iwanami, N., Sikora, K., Richter, A.S., Mönnich, M., Guerri, L., Soza-Ried, C., Lawir, D.F., Mateos, F., Hess, I., O'Meara, C.P., Schorpp, M., Boehm, T. (2016) Forward Genetic Screens in Zebrafish Identify Pre-mRNA-Processing Pathways Regulating Early T Cell Development. Cell Reports. 17:2259-2270

Hess, I., Boehm, T. (2016) Stable multilineage xenogeneic replacement of definitive hematopoiesis in adult zebrafish. Scientific Reports. 6:19634

Swann, J.B., Weyn, A., Nagakubo, D., Bleul, C.C., Toyoda, A., Happe, C., Netuschil, N., Hess, I., Haas-Assenbaum, A., Taniguchi, Y., Schorpp, M., Boehm, T. (2014) Conversion of the thymus into a bipotent lymphoid organ by replacement of FOXN1 with its paralog, FOXN4. Cell Reports. 8:1184-97

Venkatesh, B., Lee, A.P., Ravi, V., Maurya, A.K., Lian, M.M., Swann, J.B., Ohta, Y., Flajnik, M.F., Sutoh, Y., Kasahara, M., Hoon, S., Gangu, V., Roy, S.W., Irimia, M., Korzh, V., Kondrychyn, I., Lim, Z.W., Tay, B.H., Tohari, S., Kong, K.W., Ho, S., Lorente-Galdos, B., Quilez, J., Marques-Bonet, T., Raney, B.J., Ingham, P.W., Tay, A., Hillier, L.W., Minx, P., Boehm, T., Wilson, R.K., Brenner, S., and Warren, W.C. (2014) Elephant shark genome provides unique insights into gnathostome evolution. Nature. 505(7482):174-179

Hess, I., Iwanami, N., Schorpp, M., and Boehm, T. (2013) Zebrafish model for allogeneic hematopoietic cell transplantation not requiring preconditioning. Proceedings of the National Academy of Sciences of the United States of America. 110(11):4327-32

Hess, I., and Boehm, T. (2012) Intravital Imaging of Thymopoiesis Reveals Dynamic Lympho-Epithelial Interactions. Immunity. 36(2):298-309

Iwanami, N., Mateos, F., Hess, I., Riffel, N., Soza-Ried, C., Schorpp, M., and Boehm, T. (2011) Genetic Evidence for an Evolutionarily Conserved Role of IL-7 Signaling in T Cell Development of Zebrafish. Journal of immunology (Baltimore, Md. : 1950). 186(12):7060-6

Soza-Ried, C., Hess, I., Netuschil, N., Schorpp, M., and Boehm, T. (2010) Essential role of c-myb in definitive hematopoiesis is evolutionarily conserved. Proceedings of the National Academy of Sciences of the United States of America. 107(40):17304-17308

Mönnich, M., Hess, I., Wiest, W., Bachrati, C., Hickson, I.D., Schorpp, M., and Boehm, T. (2010) Developing T lymphocytes are uniquely sensitive to a lack of topoisomerase III alpha. European journal of immunology. 40(9):2379-2384

Bajoghli, B., Aghaallaei, N., Hess, I., Rode, I., Netuschil, N., Tay, B.H., Venkatesh, B., Yu, J.K., Kaltenbach, S.L., Holland, N.D., Diekhoff, D., Happe, C., Schorpp, M., and Boehm, T. (2009) Evolution of genetic networks underlying the emergence of thymopoiesis in vertebrates. Cell. 138(1):186-197

Pannicke, U., Hönig, M., Hess, I., Friesen, C., Holzmann, K., Rump, E.M., Barth, T.F., Rojewski, M.T., Schulz, A., Boehm, T., Friedrich, W., and Schwarz, K. (2009) Reticular dysgenesis (aleukocytosis) is caused by mutations in the gene encoding mitochondrial adenylate kinase 2. Nature Genetics. 41(1):101-105

Soza-Ried, C., Bleul, C.C., Schorpp, M., and Boehm, T. (2008) Maintenance of thymic epithelial phenotype requires extrinsic signals in mouse and zebrafish. Journal of immunology (Baltimore, Md. : 1950). 181(8):5272-5277

Schorpp, M., Bialecki, M., Diekhoff, D., Walderich, B., Odenthal, J., Maischein, H.M., Zapata, A.G., and Boehm, T. (2006) Conserved functions of ikaros in vertebrate lymphocyte development: genetic evidence for distinct larval and adult phases of T cell development and two lineages of B cells in zebrafish. Journal of immunology (Baltimore, Md. : 1950). 177(4):2463-2476

Boehm, T., Bleul, C.C., and Schorpp, M. (2003) Genetic dissection of thymus development in mouse and zebrafish. Immunological reviews. 195:15-27

Schorpp, M., Leicht, M., Nold, E., Hammerschmidt, M., Haas-Assenbaum, A., Wiest, W., and Boehm, T. (2002) A zebrafish orthologue (whnb) of the mouse nude gene is expressed in the epithelial compartment of the embryonic thymic rudiment. Mechanisms of Development. 118(1-2):179-185

Schlake, T., Schorpp, M., and Boehm, T. (2000) Formation of regulator/target gene relationships during evolution. Gene. 256(1-2):29-34

Schlake, T., Schorpp, M., Nehls, M., and Boehm, T. (1997) The nude gene encodes a sequence-specific DNA binding protein with homologs in organisms that lack an anticipatory immune system. Proceedings of the National Academy of Sciences of the United States of America. 94(8):3842-3847