ERAD pathway

Term ID

GO:0036503

Synonyms

• endoplasmic reticulum-associated degradation
• endoplasmic reticulum-associated protein degradation pathway
• ER-associated degradation pathway
• protein degradation by ERAD

Definition

The protein catabolic pathway which targets endoplasmic reticulum (ER)-resident proteins for degradation by the cytoplasmic proteasome. It begins with recognition of the ER-resident protein, includes retrotranslocation (dislocation) of the protein from the ER to the cytosol, protein modifications necessary for correct substrate transfer (e.g. ubiquitination), transport of the protein to the proteasome, and ends with degradation of the protein by the cytoplasmic proteasome. (2)

References

Ontology

GO: Biological Process    QuickGO    AmiGO