sulindac

Term ID

CHEBI:9352

Synonyms

• (Z)-5-Fluoro-2-methyl-1-((p-(methylsulfinyl)phenyl)methylene)-1H-indene-3-acetic acid
• cis-5-Fluoro-2-methyl-1-((4-(methylsulfinyl)phenyl)methylene)-1H-indene-3-acetic acid
• cis-5-Fluoro-2-methyl-1-((p-methylsulfinyl)benzylidene)indene-3-acetic acid
• Clinoril
• sulindac
• sulindaco
• Sulindacum
• {(1Z)-5-fluoro-2-methyl-1-[4-(methylsulfinyl)benzylidene]-1H-inden-3-yl}acetic acid

Definition

A monocarboxylic acid that is 1-benzylidene-1H-indene which is substituted at positions 2, 3, and 5 by methyl, carboxymethyl, and fluorine respectively, and in which the phenyl group of the benzylidene moiety is substituted at the para position by a methylsulfinyl group. It is a prodrug for the corresponding sulfide, a non-steroidal anti-inflammatory drug, used particularly in the treatment of acute and chronic inflammatory conditions.

References

• Beilstein:2951842
• CAS:38194-50-2
• DrugBank:DB00605
• Drug_Central:2534
• HMDB:HMDB0014743
• KEGG:C01531
• KEGG:D00120
• PDBeChem:SUZ
• PMID:11569947
• PMID:11927004
• PMID:12406542
• PMID:15020200
• PMID:15123337
• PMID:19884509
• PMID:23689354
• PMID:23804703
• Patent:DE2039426
• Patent:US3654349
• Reaxys:2951842
• Wikipedia:Sulindac

Ontology

ChEBI  ( EBI )

Resources

CTD