indoprofen

Term ID

CHEBI:76162

Synonyms

• 1-Oxo-2-(p-((alpha-methyl)carboxymethyl)phenyl)isoindoline
• 2-(4-(1-Carboxyethyl)phenyl)-1-isoindolinone
• 2-[4-(1-oxo-1,3-dihydro-2H-isoindol-2-yl)phenyl]propanoic acid
• alpha-(4-(1-Oxo-2-isoindolinyl)phenyl)propionic acid
• indoprofen
• indoprofene
• indoprofeno
• indoprofenum
• K 4277

Definition

A monocarboxylic acid that is propionic acid in which one of the hydrogens at position 2 is substituted by a 4-(1-oxo-1,3-dihydroisoindol-2-yl)phenyl group. Initially used as an anti-inflammatory and analgesic, it was withdrawn from the market due to causing severe gastrointestinal bleeding. It has been subsequently found to increase production of the survival motor neuron protein.

References

• CAS:31842-01-0
• Drug_Central:1442
• KEGG:D04530
• LINCS:LSM-1564
• PMID:1017174
• PMID:22282415
• PMID:22349325
• PMID:2519164
• PMID:2753348
• PMID:2775332
• PMID:369767
• PMID:378745
• PMID:392647
• PMID:47280
• PMID:550151
• PMID:6436749
• PMID:6578800
• PMID:7042369
• PMID:7341277
• PMID:7349186
• PMID:7428321
• Patent:NZ586198
• Patent:WO2008011083
• Reaxys:1543920
• Wikipedia:Indoprofen

Ontology

ChEBI  ( EBI )

Resources

CTD