mevinic acid

Term ID

CHEBI:39508

Synonyms

• (3R,5R)-3,5-dihydroxy-7-[(1S,2S,8S,8aR)-2-methyl-8-{[(2S)-2-methylbutanoyl]oxy}-1,2,6,7,8,8a-hexahydronaphthalen-1-yl]heptanoic acid
• compactin acid
• mevastatin (acid form)
• mevastatin acid
• mevastatin hydroxy acid
• ML 236B acid
• ML-236B acid

Definition

A member of the class of hexahydronaphthalenes that is 1,2,6,7,8,8a-hexahydronaphthalene which is substituted by a (3R,5R)-6-carboxy-3,5-dihydroxyhexyl group at position 1, a methyl group at position 2, and a (2S)-2-methylbutanoyloxy group at position 8 (the 1S,2S,8S,8aR isomer). Lactonisation of the hydroxy-carboxylic acid chain at position 1 affords mevastatin.

References

• CAS:84064-38-0
• PDBeChem:114
• PMID:1010803
• PMID:16042349
• Patent:EP0401784
• Patent:EP0428094

Ontology

ChEBI  ( EBI )