midafotel

Term ID

CHEBI:180900

Synonyms

• (2R)-4-[(2E)-3-phosphono-2-propenyl]-2-piperazinecarboxylic acid
• (2R)-4-[(2E)-3-phosphonoprop-2-en-1-yl]piperazine-2-carboxylic acid
• (R)-4-[(E)-3-phosphonoprop-2-enyl]piperazine-2-carboxylic acid
• (R)-CPP-ene
• D(-)CPPene
• D-4-[(2E)-3-phosphono-2-propenyl]-2-piperazinecarboxylic acid
• D-CPP-ene
• D-CPPene
• midafotel
• midafotelum
• SDZ EAA 494
• SDZ-EAA 494
• SDZ-EAA-494

Definition

A member of the class of piperazines that is piperazine substituted by a carboxy group at position 2R and a (1E)-1-phosphonoprop-1-en-3-yl group at position 4. It is an antagonist of N-methyl-D-aspartate receptors (NMDARs) and was in clinical development by Novartis for the treatment of cognition disorders and brain injuries (now discontinued).

References

• CAS:117414-74-1
• Chemspider:4940497
• PMID:10422758
• PMID:10708738
• PMID:11396518
• PMID:1480321
• PMID:15497436
• PMID:1834008
• PMID:1930876
• PMID:2147454
• PMID:2166255
• PMID:2166743
• PMID:2292244
• PMID:31563294
• PMID:32507787
• PMID:7675315
• PMID:7892415
• PMID:7894335
• PMID:7936096
• PMID:7942207
• PMID:7976650
• PMID:8194512
• PMID:8223415
• PMID:8269915
• PMID:8581475
• PMID:8740048
• PMID:8901001
• PMID:8982681
• PMID:9026366
• PMID:9721021
• PMID:9726648
• Wikipedia:Midafotel

Ontology

ChEBI  ( EBI )