NMDA receptor antagonist

Term ID

CHEBI:60643

Synonyms

N-methyl-D-aspartate receptor antagonist
N-methyl-D-aspartate receptor antagonists
NMDA receptor antagonists
NMDAR antagonist
NMDAR antagonists

Definition

Any substance that inhibits the action of N-methyl-D-aspartate (NMDA) receptors. They tend to induce a state known as dissociative anesthesia, marked by catalepsy, amnesia, and analgesia, while side effects can include hallucinations, nightmares, and confusion. Due to their psychotomimetic effects, many NMDA receptor antagonists are used as recreational drugs.

References

Ontology

ChEBI ( EBI )

Relationships

is a type of: excitatory amino acid antagonist

excitatory amino acid antagonist Show first 5 Terms
inverse has_role: (1R,2S)-nortilidine (2R,3S)-PPDA (2S,3R)-PPDA (R)-ketamine (R,R)-tramadol ... Show All 49 Terms

(1R,2S)-nortilidine (2R,3S)-PPDA (2S,3R)-PPDA (R)-ketamine (R,R)-tramadol (R,R)-tramadol hydrochloride (S,S)-tramadol (S,S)-tramadol hydrochloride 2-amino-5-phosphonopentanoic acid 7-chlorokynurenic acid amantadine amantadine hydrochloride amantadine sulfate CGP 78608 CGP 78608 hydrochloride dextromethadone dextromethorphan dinitrogen oxide dizocilpine dizocilpine maleate eliprodil esketamine esketamine hydrochloride ethanol ginsenoside Rb3 isoliquiritigenin ketamine ketamine hydrochloride kynurenic acid levomethadone memantine memantine hydrochloride methadone midafotel N-[2-(4-phenoxybenzyl)benzimidazol-5-yl]methanesulfonamide N-{2-[(4-benzylpiperidin-1-yl)methyl]benzimidazol-5-yl}methanesulfonamide noribogaine orphenadrine orphenadrine citrate orphenadrine hydrochloride pentamidine phencyclidine PPDA Ro 25-6981 Ro 25-6981 maleate rolicyclidine tenocyclidine tramadol tramadol hydrochloride Show first 5 Terms

Phenotype

Phenotype resulting from NMDA receptor antagonist

Phenotype where environments contain NMDA receptor antagonist

Phenotype modified by environments containing NMDA receptor antagonist

Human Disease / Model Data

Citations