fostriecin

Term ID

CHEBI:167004

Synonyms

• (+)-fostriecin
• (1E,3R,4R,6R,7Z,9Z,11E)-3,6,13-trihydroxy-3-methyl-1-[(2R)-6-oxo-3,6-dihydro-2H-pyran-2-yl]trideca-1,7,9,11-tetraen-4-yl dihydrogen phosphate
• (6R)-5,6-dihydro-6-[(1E,3R,4R,6R,7Z,9Z,11E)-3,6,13-trihydroxy-3-methyl-4-(phosphonooxy)-1,7,9,11-tridecatetraenyl]-2H-pyran-2-one
• antibiotic CI 920
• antibiotic CL 1565A
• CI 920
• CI-920
• CL 1565A
• CL-1565A
• fostriecin
• fostriecina
• fostriecine
• fostriecinum
• PD 110,161
• PD 110161
• PD-110,161
• phosphotrienin

Definition

A structurally unique, naturally-occurring phosphate monoester isolated from the soil bacterium Streptomyces pulveraceus. It inhibits DNA topoisomerase II as well as several protein phosphatase including PP2A and PPA4, and exhibits potent antitumor activity against several cancer cell lines.

References

• CAS:87810-56-8
• Chemspider:4510160
• KNApSAcK:C00018551
• PMID:11457179
• PMID:12119701
• PMID:12369868
• PMID:12489943
• PMID:12837094
• PMID:16316259
• PMID:19592665
• PMID:19902969
• PMID:20645347
• PMID:20687585
• PMID:23352138
• PMID:23586868
• PMID:23671329
• PMID:28027648
• PMID:28090813
• PMID:31584287
• PMID:33184589
• PMID:9738645
• Wikipedia:Fostriecin

Ontology

ChEBI  ( EBI )

Resources

CTD