roducitabine

Term ID

CHEBI:147412

Synonyms

1-[(1S,4R,5S)-2-fluoro-3-(hydroxymethyl)-4,5-dihydroxy-2-cyclopentenyl]cytosine
4-amino-1-[(1S,4R,5S)-2-fluoro-4,5-dihydroxy-3-(hydroxymethyl)cyclopent-2-en-1-yl]-1,2-dihydropyrimidin-2-one
4-amino-1-[(1S,4R,5S)-2-fluoro-4,5-dihydroxy-3-(hydroxymethyl)cyclopent-2-en-1-yl]pyrimidin-2(1H)-one
fluorocyclopentenyl cytosine
fluorocyclopentenyl-cytosine
fluorocyclopentenylcytosine
RX 3117
RX-3117
RX3117
TV-1360

Definition

A triol that is (1S,2R)-4-fluoro-3-(hydroxymethyl)cyclopent-3-ene-1,2-diol which is substituted by a 4-amino-2-oxopyrimidin-1(2H)-yl group at position 5. It is a cytidine analog which exhibits anticancer activity in several cancers, including gemcitabine-resistant tumours.

References

Ontology

ChEBI ( EBI )

Relationships

is a type of: organofluorine compound primary allylic alcohol triol

organofluorine compound primary allylic alcohol triol Show first 5 Terms
has_role: antimetabolite antineoplastic agent apoptosis inducer DNA synthesis inhibitor prodrug

antimetabolite antineoplastic agent apoptosis inducer DNA synthesis inhibitor prodrug Show first 5 Terms

Phenotype

Phenotype resulting from roducitabine

Phenotype where environments contain roducitabine

Phenotype modified by environments containing roducitabine

Human Disease / Model Data

Citations