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OBO ID: GO:0140358
Term Name: P-type transmembrane transporter activity Search Ontology:
Synonyms:
  • E1-E2 ATPase
  • P-type ATPase
Definition: Primary active transporter that auto-phosphorylates (hence P) at a key conserved aspartate residue, generating a conformational change that allows transport of the substrate. Hydrolysis of the phosphorylated Asp residue, catalyzed by the actuator (A) domain, results in another state with occluded substrates. Upon dissociation of Mg2+ and inorganic phosphate (Pi), the enzyme reverts to the initial state, in which the counter-transported substrate is released into the cytosol. (2)
References:
Ontology: GO: Molecular Function   QuickGO   AmiGO
PHENOTYPE No data available