OBO ID: CHEBI:74514
Term Name: 6-aminonicotinamide Search Ontology:
Synonyms:
  • 2-amino-5-carbamoylpyridine
  • 6-amino-3-pyridinecarboxamide
  • 6-aminonicotinamide
  • 6-aminonicotinic acid amide
  • 6-Aminonikotinsaeureamid
  • 6-AN
  • 6-ANA
  • SR 4388
Definition: A monocarboxylic acid amide resulting from the formal condensation of the carboxy group of 6-aminonicotinic acid with ammonia. An inhibitor of the NADP(+)-dependent enzyme, 6-phosphogluconate dehydrogenase, it interferes with glycolysis, resulting in ATP depletion and synergizes with DNA-crosslinking chemotherapy drugs, such as cisplatin, in killing cancer cells.
References:
Ontology: Chebi
PHENOTYPE No data available