OBO ID: CHEBI:156303

Term Name:	colibactin		Search Ontology:
Synonyms:	2-{6-[(2S)-2-methyl-3,4-dihydro-2H-pyrrol-5-yl]-5-oxo-4-azaspiro[2.4]hept-6-en-7-yl}-N-({4-[{4-[(2-{6-[(2S)-2-methyl-3,4-dihydro-2H-pyrrol-5-yl]-5-oxo-4-azaspiro[2.4]hept-6-en-7-yl}acetamido)acetyl]-1,3-thiazol-2-yl}(oxo)acetyl]-1,3-thiazol-2-yl}methyl)ac
Definition:	A member of the class of 1,3-thiazoles that comprises of two units of 2-[(2-{6-[(2S)-2-methyl-3,4-dihydro-2H-pyrrol-5-yl]-5-oxo-4-azaspiro[2.4]hept-6-en-7-yl}acetamido)methyl]-1,3-thiazole-4-carboxylic acid linked together via the formal condensation of the carboxy groups. It is a secondary metabolite produced by certain strains of bacteria found in the human gut such as Escherichia coli. It has the ability to bind covalently to DNA and is strongly associated with colorectal cancer.
References:	MetaCyc:CPD-22719 PMID:17224306 PMID:29642622 PMID:30765538 PMID:31395743 PMID:31527851 PMID:31541229 PMID:31578245 PMID:31977191 PMID:32037530 PMID:32169880 PMID:32175032 PMID:32317778 PMID:32475872 PMID:32483361 PMID:32507544 PMID:32527463 PMID:32611705 PMID:32661091 PMID:32669458 PMID:32727866 PMID:32767847
Ontology:	ChEBI  ( EBI )