Gene
gsk3ba
- ID
- ZDB-GENE-990714-4
- Name
- glycogen synthase kinase 3 beta, genome duplicate a
- Symbol
- gsk3ba Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 9 Mapping Details/Browsers
- Description
- Predicted to have beta-catenin binding activity; protein serine/threonine kinase activity; and tau-protein kinase activity. Involved in angiogenesis; heart jogging; and heart looping. Predicted to localize to several cellular components, including axon; beta-catenin destruction complex; and glutamatergic synapse. Human ortholog(s) of this gene implicated in Alzheimer's disease; amyotrophic lateral sclerosis; bipolar disorder; and schizophrenia. Is expressed in ovary and testis. Orthologous to human GSK3B (glycogen synthase kinase 3 beta).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 10 figures from 9 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 11 figures from 2 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR008271 | Serine/threonine-protein kinase, active site |
| Binding_site | IPR017441 | Protein kinase, ATP binding site |
| Domain | IPR000719 | Protein kinase domain |
| Domain | IPR039192 | Glycogen synthase kinase 3, catalytic domain |
| Homologous_superfamily | IPR011009 | Protein kinase-like domain superfamily |
Domain Details Per Protein
| Protein | Length | Glycogen synthase kinase 3, catalytic domain | Protein kinase, ATP binding site | Protein kinase domain | Protein kinase-like domain superfamily | Serine/threonine-protein kinase, active site |
|---|---|---|---|---|---|---|
|
UniProtKB:Q9YH60
|
421 | |||||
|
UniProtKB:A0A8M3AVR7
|
425 |
Interactions and Pathways
Plasmids